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Current therapies include psychotherapy coupled with medication; however, high relapse rates reveal the shortcomings of these therapies. The signalling, expression profile, and neurological function of the serotonin 2C receptor (5\u2010HT\n                    <jats:sub>2C<\/jats:sub>\n                    receptor) make it a candidate of interest for the treatment of SUD. Recently, psychedelics, which broadly act at 5\u2010HT\n                    <jats:sub>2<\/jats:sub>\n                    receptors, have indicated potential for the treatment of SUD, implicating the 5\u2010HT\n                    <jats:sub>2C<\/jats:sub>\n                    receptor. The modern psychedelic movement has rekindled interest in the 5\u2010HT\n                    <jats:sub>2C<\/jats:sub>\n                    receptor, resulting in many new studies, especially structural analyses. This review explores the structural, molecular and cellular mechanisms governing 5\u2010HT\n                    <jats:sub>2C<\/jats:sub>\n                    receptor function in the context of SUD. This provides the basis of the preclinical and clinical evidence for their role in SUD and highlights the potential for future exploration.\n                  <\/jats:p>","DOI":"10.1111\/bph.16233","type":"journal-article","created":{"date-parts":[[2023,9,8]],"date-time":"2023-09-08T01:59:22Z","timestamp":1694138362000},"page":"4414-4429","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Molecular and structural insights into the 5\u2010HT\n                    <sub>2C<\/sub>\n                    receptor as a therapeutic target for substance use disorders"],"prefix":"10.1111","volume":"181","author":[{"given":"Maleesha","family":"Ubhayarathna","sequence":"first","affiliation":[{"name":"Drug Discovery Biology and Neuroscience &amp; Mental Health Therapeutic Program Area, Monash Institute of Pharmaceutical Sciences Monash University  Parkville Australia"},{"name":"ARC Centre for Cryo\u2010electron Microscopy of 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