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Sinomenine<\/jats:italic> has been shown to mediate a wide range of pharmacological actions and is known to possess good anti\u2010inflammatory, immunosuppressive, antitumor, neuroprotective, antiarrhythmic and other pharmacological effects. Understanding the underlying mechanisms and the association between the targets and the pharmaceutical effects on different diseases is crucial to the discovery and design of new treatment strategies. In this review, we aim to give a systematic and comprehensive overview of the research progress of sinomenine over the past 20\u2009years. We first describe the metabolism of sinomenine <jats:italic>in vivo<\/jats:italic> and then summarize the pharmacological actions of sinomenine on different diseases. Furthermore, the potential binding properties of sinomenine and the potential of developing new sinomenine\u2010based drugs are also reviewed.<\/jats:p><\/jats:sec><jats:sec><jats:title>LINKED ARTICLES<\/jats:title><jats:p>This article is part of a themed issue Natural Products and Cancer: From Drug Discovery to Prevention and Therapy. To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v182.10\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v182.10\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.16267","type":"journal-article","created":{"date-parts":[[2023,10,17]],"date-time":"2023-10-17T08:07:23Z","timestamp":1697530043000},"page":"2159-2180","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["From mundane to classic: Sinomenine as a multi\u2010therapeutic agent"],"prefix":"10.1111","volume":"182","author":[{"given":"Dan","family":"Li","sequence":"first","affiliation":[{"name":"State Key Laboratory of Southwestern Chinese Medicine Resources, School of Pharmacy Chengdu University of Traditional Chinese Medicine  Chengdu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhangfeng","family":"Zhong","sequence":"additional","affiliation":[{"name":"Macao Centre for Research and Development in Chinese Medicine, Institute of Chinese Medical Sciences University of Macau  Macao SAR China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chung\u2010Nga","family":"Ko","sequence":"additional","affiliation":[{"name":"The International Eye Research Institute of The Chinese University of Hong Kong (Shenzhen)  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiantian","family":"Tian","sequence":"additional","affiliation":[{"name":"Center for Biological Science and Technology, Advanced Institute of Natural Sciences Beijing Normal University at Zhuhai  Zhuhai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Yang","sequence":"additional","affiliation":[{"name":"National Engineering Research Center For Marine 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