{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T20:20:27Z","timestamp":1782505227542,"version":"3.54.5"},"reference-count":210,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2023,12,3]],"date-time":"2023-12-03T00:00:00Z","timestamp":1701561600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["1K99HL168224\u201001"],"award-info":[{"award-number":["1K99HL168224\u201001"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2026,1]]},"abstract":"<jats:sec>\n                    <jats:label\/>\n                    <jats:p>\n                      Nitric oxide (\n                      <jats:sup>\u2022<\/jats:sup>\n                      NO) interactions with biological thiols play crucial, but incompletely determined, roles in vascular signalling and other biological processes. Here, we highlight two recently proposed signalling paradigms: (1) the formation of a vasodilating labile nitrosyl ferrous haem (NO\u2013ferrohaem) facilitated by thiols via thiyl radical generation and (2) polysulfides\/persulfides and their interaction with\n                      <jats:sup>\u2022<\/jats:sup>\n                      NO. We also describe the specific (bio)chemical routes in which\n                      <jats:sup>\u2022<\/jats:sup>\n                      NO and thiols react to form\n                      <jats:italic>S<\/jats:italic>\n                      \u2010nitrosothiols, a broad class of small molecules, and protein post\u2010translational modifications that can influence protein function through catalytic site or allosteric structural changes.\n                      <jats:italic>S<\/jats:italic>\n                      \u2010Nitrosothiol formation depends upon cellular conditions, but critically, an appropriate oxidant for either the thiol (yielding a thiyl radical) or\n                      <jats:sup>\u2022<\/jats:sup>\n                      NO (yielding a nitrosonium [NO\n                      <jats:sup>+<\/jats:sup>\n                      ]\u2010donating species) is required. We examine the roles of these collective\n                      <jats:sup>\u2022<\/jats:sup>\n                      NO\/thiol species in vascular signalling and their cardiovascular therapeutic potential.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LINKED ARTICLES<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed issue Recent Innovations in Targeting Redox Biology for Therapeutics. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v183.1\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v183.1\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.16274","type":"journal-article","created":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T01:44:51Z","timestamp":1698803091000},"page":"5-23","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Nitric oxide and thiols: Chemical biology, signalling paradigms and vascular therapeutic potential"],"prefix":"10.1111","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7704-4867","authenticated-orcid":false,"given":"Matthew R.","family":"Dent","sequence":"first","affiliation":[{"name":"Heart, Lung, Blood, and Vascular Medicine Institute University of Pittsburgh  Pittsburgh Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5303-5758","authenticated-orcid":false,"given":"Anthony W.","family":"DeMartino","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Maryland School of Medicine  Baltimore Maryland 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