{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:23:16Z","timestamp":1789154596100,"version":"build-2803163510"},"reference-count":172,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2023,12,26]],"date-time":"2023-12-26T00:00:00Z","timestamp":1703548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:sec><jats:label\/><jats:p>Intracellular accumulation of hyperphosphorylated misfolded tau proteins are found in many neurodegenerative tauopathies, including Alzheimer's disease (AD). Tau pathology can impact cerebrovascular physiology and function through multiple mechanisms. <jats:italic>In vitro<\/jats:italic> and <jats:italic>in vivo<\/jats:italic> studies have shown that alterations in the blood\u2013brain barrier (BBB) integrity and function can result in synaptic abnormalities and neuronal damage. In the present review, we will summarize how tau proteostasis dysregulation contributes to vascular dysfunction and, conversely, we will examine the factors and pathways leading to tau pathological alterations triggered by cerebrovascular dysfunction. Finally, we will highlight the role epigenetic and epitranscriptomic factors play in regulating the integrity of the cerebrovascular system and the progression of tauopathy including a few observartions on potential therapeutic interventions.<\/jats:p><\/jats:sec><jats:sec><jats:title>LINKED ARTICLES<\/jats:title><jats:p>This article is part of a themed issue From Alzheimer's Disease to Vascular Dementia: Different Roads Leading to Cognitive Decline. To view the other articles in this section visit <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v181.6\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v181.6\/issuetoc<\/jats:ext-link><\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.16280","type":"journal-article","created":{"date-parts":[[2023,11,6]],"date-time":"2023-11-06T01:54:00Z","timestamp":1699235640000},"page":"879-895","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Mechanisms linking cerebrovascular dysfunction and tauopathy: Adding a layer of epiregulatory complexity"],"prefix":"10.1111","volume":"181","author":[{"given":"Yoon A.","family":"Kim","sequence":"first","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University  New York New York USA"},{"name":"Department of Pathology and Cell Biology Columbia University  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marian","family":"Mellen","sequence":"additional","affiliation":[{"name":"Facultad de Ciencias Experimentales Universidad Francisco de Vitoria  Pozuelo de Alarcon Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caghan","family":"Kizil","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University  New York New York USA"},{"name":"Department of Neurology Columbia University Irving Medical Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ismael","family":"Santa\u2010Maria","sequence":"additional","affiliation":[{"name":"Taub Institute for Research on Alzheimer's Disease and the Aging Brain Columbia University  New York New York USA"},{"name":"Department of Pathology and Cell Biology Columbia University  New York New York USA"},{"name":"Facultad de Ciencias Experimentales Universidad Francisco de Vitoria  Pozuelo de Alarcon Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2023,12,26]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2021.102993"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1171-0"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1230-20.2020"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15538"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15541"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15542"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15537"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2004.08.010"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1177\/1179069519832286"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09613"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm.2015.27"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2017.07.755"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnana.2017.00101"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(15)00461-4"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858417707457"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)63421-9"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15604"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.1787609"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2018.05.005"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awaa033"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1080\/23262133.2017.1322666"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.1782-16.2016"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40478-015-0186-2"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-150704"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2018.07.072"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81053-3"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dadm.2016.03.006"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.573324"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abc8096"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1702"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-018-0270-8"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-023-05788-0"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s43587-022-00181-4"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-016-0139-7"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-021-00476-x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00022.2020"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2021.1916469"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.2217\/epi-2022-0239"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2019.03.090"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-014-1349-0"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2020.555372"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2010.01.011"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a028035"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1880-5"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2006.05.001"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13195-021-00951-z"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2007.01.005"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-0082(00)00068-x"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-021-02379-z"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(14)70065-1"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm305"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-010-0649-2"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13072-018-0211-3"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1177\/1073858417721150"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1111\/nan.12213"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232315218"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22168465"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1460-2075.1989.tb03390.x"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pathmechdis-012418-012936"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.629068"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng1158"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.859"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/31508"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1161\/STR.0000000000000431"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.3003748"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2022.114979"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms11934"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315938"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1044-y"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-015-1407-2"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jns.2007.01.045"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2021.07.038"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.63.11.1632"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-020-0322-2"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11940-012-0168-7"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02196-w"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-022-02511-7"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-022-02511-7"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4489"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0291-1"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.7569905"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-020-02215-w"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.3109\/07853898909149195"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awr234"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-013-1087-8"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8247"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-802395-2.00025-0"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1097\/NEN.0b013e318187a80f"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2990.2012.01272.x"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.628415"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41588-019-0495-7"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-022-02431-6"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneumeth.2005.09.013"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.neuro.24.1.1121"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2019.09.002"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2018.02.201"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-021-02205-z"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.14802\/jmd.15060"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1186\/1750-1326-3-8"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.3792"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.115.307674"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.739201"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0217216"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.25911"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-017-1348-2"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0253-7"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2012.05.003"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnmol.2020.570045"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2017.03.004"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP270979"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.4428"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2021.105530"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1080\/15592294.2020.1722917"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0101-9"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2015.12.016"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes12122005"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2020.00350"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2022.11.004"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2022.02.013"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2018.06.005"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-022-01078-9"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-020-0686-7"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-021-01456-w"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2021.639428"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncel.2018.00172"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(10)70299-4"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1002\/ana.410430617"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-023-00139-x"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201701045"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra0909142"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2015.00136"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108398"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.abl7122"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201601308"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-012-1017-1"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-021-00904-7"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.add1236"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbadis.2004.06.020"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-020-02249-z"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03911-7"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00537"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1750-3639.1998.tb00162.x"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(13)70090-5"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.702832"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-7-64"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1179\/016164105X49463a"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12987-022-00317-z"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-018-0234-x"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.12.099"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnen\/61.6.547"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0072-9752(07)01251-1"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.2c01003"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2020.01.003"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.134919"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-160527"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.2967\/jnumed.122.263926"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-023-06196-2"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2023.106829"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn.2015.1"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1998.70041346.x"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2018.06.025"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.102171"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/cr.2017.62"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1678-1"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13024-022-00533-z"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awy354"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b00017"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-9-S2-S10"},{"issue":"9","key":"e_1_2_10_170_1","first-page":"374","article-title":"Neuroinflammation in Alzheimer's disease: Protector or promoter?","volume":"107","author":"Zilka N.","year":"2006","journal-title":"Bratislavsk\u00e9 Lek\u00e1rske Listy"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10113064"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn3114"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.3389\/fgene.2021.719456"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.16280","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,2,8]],"date-time":"2024-02-08T07:45:38Z","timestamp":1707378338000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.16280"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,12,26]]},"references-count":172,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,3]]}},"alternative-id":["10.1111\/bph.16280"],"URL":"https:\/\/doi.org\/10.1111\/bph.16280","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,12,26]]},"assertion":[{"value":"2023-03-19","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-09-30","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2023-12-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}