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This study explored its potential as an antirheumatic target.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>\n                      WAT status of healthy and adjuvant\u2010induced arthritis (AIA) rats were compared. The contribution of WAT to RA pathology was evaluated by pre\u2010adipocyte transplant experiments and by dissecting perirenal fat pads of AIA rats. The impact of RA on WAT was investigated by culturing pre\u2010adipocytes. Proteins differentially expressed in WAT of healthy and AIA rats were identified by the UPLC\/MS\n                      <jats:sup>2<\/jats:sup>\n                      method. These together with PPAR\u03b3 siRNA and agonist were used to treat pre\u2010adipocytes in vitro. The medium was used for THP\u20101 monocyte culture.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>Compared with healthy controls, AIA WAT was smaller but secreted more leptin, eNAMPT, MCP\u20101, TNF\u2010\u03b1, and IL\u20106. AIA rat pre\u2010adipocytes increased the levels of these adipokines in healthy recipients. RA patients' serum induced a similar secretion change and impaired differentiation of pre\u2010adipocytes. Adipectomy eased AIA\u2010related immune abnormalities and arthritic manifestations. Hepatokines PON1, IGFBP4, and GPIHBP1 were among the differential proteins in high levels in RA blood, and induced inflammatory secretions by pre\u2010adipocytes. GPIHBP1 inhibited PPAR\u03b3 expression and caused differentiation impairment and inflammatory secretion by pre\u2010adipocytes, a similar outcome to PPAR\u03b3\u2010silencing. This endowed the cells with an ability to activate monocytes, which can be abrogated by rosiglitazone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Implications<\/jats:title>\n                    <jats:p>Certain hepatokines potentiate inflammatory secretions by pre\u2010adipocytes and expedite RA progression by inhibiting PPAR\u03b3. Targeting this signalling or abnormal WAT secretion by various approaches may reduce RA severity.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.16360","type":"journal-article","created":{"date-parts":[[2024,4,22]],"date-time":"2024-04-22T00:01:23Z","timestamp":1713744083000},"page":"2774-2793","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["White adipose tissue, a novel antirheumatic target: Clues from its secretory capability and adipectomy\u2010based therapy"],"prefix":"10.1111","volume":"181","author":[{"given":"Peng","family":"Ye","sequence":"first","affiliation":[{"name":"Xin'an Medicine Research Center The First Affiliated Hospital of Wannan Medical College (Yijishan Hospital)  Wuhu China"},{"name":"Research Center of Integration of Traditional Chinese and Western Medicine Wannan Medical College  Wuhu 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