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Monocytes\/macrophages, activated by elevated circulating lipoproteins, are significantly involved in the formation and development of atherosclerotic plaques. The imbalance between proinflammatory and anti\u2010inflammatory macrophages, arising from dysregulated macrophage polarization, appears to be a driving force in this process. Proatherosclerotic processes acting on monocytes\/macrophages include accumulation of cholesterol in macrophages leading to foam cell formation, as well as dysfunctional efferocytosis, all of which contribute to the formation of unstable plaques. In recent years, microRNAs (miRs) were identified as factors that could modulate monocyte\/macrophage function and may therefore interfere with the atherosclerotic process. In this review, we present effects of monocyte\/macrophage\u2010derived miRs on atherosclerotic processes in order to reveal new treatment options using miRmimics or antagomiRs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LINKED ARTICLES<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed issue Non\u2010coding RNA Therapeutics. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v182.2\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v182.2\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.16367","type":"journal-article","created":{"date-parts":[[2024,4,4]],"date-time":"2024-04-04T22:06:40Z","timestamp":1712268400000},"page":"206-219","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Monocytic microRNAs\u2014Novel targets in atherosclerosis therapy"],"prefix":"10.1111","volume":"182","author":[{"given":"Gerhild","family":"Euler","sequence":"first","affiliation":[{"name":"Institute of Physiology Justus Liebig University  Giessen 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