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Associations between conditions and genetic loci are often studied via single nucleotide polymorphism (SNP) prevalence in case versus control populations. In the <jats:italic>CNR2<\/jats:italic> coding exon, ~36 SNPs have high overall population prevalence (minor allele frequencies [MAF] ~37%), including non\u2010synonymous SNP (ns\u2010SNP) rs2501432 encoding CB<jats:sub>2<\/jats:sub> 63Q\/R. Interspersed are ~27 lower frequency SNPs, four being ns\u2010SNPs. <jats:italic>CNR2<\/jats:italic> introns also harbour numerous SNPs. This review summarises CB<jats:sub>2<\/jats:sub> ns\u2010SNP molecular pharmacology and evaluates evidence from ~70 studies investigating CB<jats:sub>2<\/jats:sub> genetic variants with proposed linkage to disease. Although <jats:italic>CNR2<\/jats:italic> genetic variation has been associated with a wide variety of conditions, including osteoporosis, immune\u2010related disorders, and mental illnesses, further work is required to robustly validate <jats:italic>CNR2<\/jats:italic> disease links and clarify specific mechanisms linking <jats:italic>CNR2<\/jats:italic> genetic variation to disease pathophysiology and potential drug responses.<\/jats:p>","DOI":"10.1111\/bph.16383","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T03:49:31Z","timestamp":1716868171000},"page":"2391-2412","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Single nucleotide polymorphisms in the cannabinoid CB<sub>2<\/sub> receptor: Molecular pharmacology and disease 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