{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:14:03Z","timestamp":1792106043071,"version":"4.4.0"},"reference-count":84,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T00:00:00Z","timestamp":1715558400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2024,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Nicorandil, a selective opener of potassium channels, used to treat angina, has drawn attention for its potential in mitigating lung injury, positioning it as a promising therapeutic approach to treat drug\u2010induced lung toxicity. This study aimed to explore the protective role of nicorandil in arsenic trioxide (ATO)\u2010induced lung injury and to elucidate the underlying mechanistic pathways.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>We assessed the effects of nicorandil (15\u2009mg\u00b7kg<jats:sup>\u22121<\/jats:sup>, p.o.) in a rat model of pulmonary injury induced by ATO (5\u00a0mg\u00b7kg<jats:sup>\u22121<\/jats:sup>, i.p.). The assessment included oxidative stress biomarkers, inflammatory cytokine levels, and other biomarkers, including sirtuin\u20101, sirtuin\u20103, STAT3, TFAM, and JAK in lung tissue. Histological examination using H&amp;E staining and molecular investigations using western blotting and PCR techniques were conducted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>In our model of lung injury, treatment with nicorandil ameliorated pathological changes as seen with H&amp;E staining, reduced tissue levels of toxicity markers, and exerted significant antioxidant and anti\u2010inflammatory actions. On a molecular level, treatment with nicorandil down\u2010regulated JAK, STAT3, PPAR\u03b3, Nrf2, VEGF, p53, and micro\u2010RNA 132 while up\u2010regulating Sirt1, 3, TFAM, AMPK, and ERR\u2010\u03b1 in lung tissue.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Implications<\/jats:title><jats:p>The results presented here show nicorandil as a significant agent in attenuating lung injury induced by ATO in a rodent model. Nonetheless, further clinical studies are warranted to strengthen these findings.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.16414","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T06:34:02Z","timestamp":1715668442000},"page":"3215-3231","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Nicorandil mitigates arsenic trioxide\u2010induced lung injury via modulating vital signalling pathways SIRT1\/PGC\u20101\u03b1\/TFAM, JAK1\/STAT3, and miRNA\u2010132 expression"],"prefix":"10.1111","volume":"181","author":[{"given":"Basel A.","family":"Abdel\u2010Wahab","sequence":"first","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy Najran University  Najran Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Zafaar","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Toxicology, Faculty of Pharmacy Modern University of Technology, and Information  Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammed Shafiuddin","family":"Habeeb","sequence":"additional","affiliation":[{"name":"Department of Pharmacology, College of Pharmacy Najran University  Najran Saudi Arabia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2448-7549","authenticated-orcid":false,"given":"Ehab A. M.","family":"El\u2010Shoura","sequence":"additional","affiliation":[{"name":"Department of Clinical Pharmacy, Faculty of Pharmacy Al\u2010Azhar University, Assiut Branch  Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,5,13]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.21608\/aijpms.2022.156529.1162"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-018-2886-y"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00210-023-02787-w"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2023.111325"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115794"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.3390\/biology11030354"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules28124665"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/biom9080346"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16179"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16181"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16180"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14112"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4240"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15101222"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0065-2776(08)60742-7"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1023\/a:1015272401822"},{"key":"e_1_2_11_18_1","volume-title":"Theory and practice of histological techniques","author":"Bancroft J. 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