{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T17:10:56Z","timestamp":1780333856136,"version":"3.54.1"},"reference-count":46,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:00:00Z","timestamp":1719792000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2019\/35\/B\/NZ5\/04432"],"award-info":[{"award-number":["2019\/35\/B\/NZ5\/04432"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2022\/45\/N\/NZ5\/03399"],"award-info":[{"award-number":["2022\/45\/N\/NZ5\/03399"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2024,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Pulmonary hypertension (PH) results from pulmonary vasculopathy, initially leading to a compensatory right ventricular (RV) hypertrophy, and eventually to RV failure. Hypoxia can trigger both pulmonary vasculopathy and RV failure. Therefore, we tested if myo\u2010inositol trispyrophosphate (ITPP), which facilitates oxygen dissociation from haemoglobin, can relieve pulmonary vasculopathy and RV hypoxia, and eventually prevent RV failure and mortality in the rat model of monocrotaline\u2010induced PH.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental approach<\/jats:title><jats:p>Rats were injected with monocrotaline (PH) or saline (control) and received ITPP or placebo for 5\u2009weeks. Serial echocardiograms were obtained to monitor the disease, pressure\u2010volume loops were recorded and evaluated, myocardial pO<jats:sub>2<\/jats:sub> was measured using a fluorescent probe, and histological and molecular analyses were conducted at the conclusion of the experiment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results and Conclusions<\/jats:title><jats:p>ITPP reduced PH\u2010related mortality. It had no effect on progressive increase in pulmonary vascular resistance, yet significantly relieved intramyocardial RV hypoxia, which was associated with improvement of RV function and reduction of RV wall stress. ITPP also tended to prevent increased hypoxia inducible factor\u20101<jats:italic>\u03b1<\/jats:italic> expression in RV cardiac myocytes but did not affect RV capillary density.<\/jats:p><\/jats:sec><jats:sec><jats:title>Implications<\/jats:title><jats:p>Our study suggests that strategies aimed at increasing oxygen delivery to hypoxic RV in PH could potentially be used as adjuncts to other therapies that target pulmonary vessels, thus increasing the ability of the RV to withstand increased afterload and reducing mortality. ITPP may be one such potential therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.16482","type":"journal-article","created":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T06:50:41Z","timestamp":1719903041000},"page":"4050-4066","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Myo\u2010inositol trispyrophosphate prevents right ventricular failure and improves survival in monocrotaline\u2010induced pulmonary hypertension in the rat"],"prefix":"10.1111","volume":"181","author":[{"given":"Marta","family":"Okni\u0144ska","sequence":"first","affiliation":[{"name":"Department of Clinical Physiology Centre of Translational Research, Centre of Postgraduate Medical Education  Warsaw Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandra","family":"Paterek","sequence":"additional","affiliation":[{"name":"Department of Clinical Physiology Centre of Translational Research, Centre of Postgraduate 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