{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T04:36:45Z","timestamp":1772253405570,"version":"3.50.1"},"reference-count":88,"publisher":"Wiley","issue":"22","license":[{"start":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T00:00:00Z","timestamp":1722384000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["I1200\/320\/2022 CVU 369878"],"award-info":[{"award-number":["I1200\/320\/2022 CVU 369878"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["A1\u2010S\u201019171"],"award-info":[{"award-number":["A1\u2010S\u201019171"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004099","name":"Ligue Contre le Cancer","doi-asserted-by":"publisher","award":["CVU1148606"],"award-info":[{"award-number":["CVU1148606"]}],"id":[{"id":"10.13039\/501100004099","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009469","name":"Conseil R\u00e9gional du Centre-Val de Loire","doi-asserted-by":"publisher","award":["CanalEx"],"award-info":[{"award-number":["CanalEx"]}],"id":[{"id":"10.13039\/501100009469","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010269","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["2016PN\u2010KFKT\u201006"],"award-info":[{"award-number":["2016PN\u2010KFKT\u201006"]}],"id":[{"id":"10.13039\/100010269","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000268","name":"Biotechnology and Biological Sciences Research Council","doi-asserted-by":"publisher","award":["BB\/C517317\/1"],"award-info":[{"award-number":["BB\/C517317\/1"]}],"id":[{"id":"10.13039\/501100000268","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009101","name":"Education Department of Henan Province","doi-asserted-by":"publisher","award":["G2022026006L"],"award-info":[{"award-number":["G2022026006L"]}],"id":[{"id":"10.13039\/501100009101","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002915","name":"Fondation pour la Recherche M\u00e9dicale","doi-asserted-by":"publisher","award":["pre\u2010R01grant"],"award-info":[{"award-number":["pre\u2010R01grant"]}],"id":[{"id":"10.13039\/501100002915","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2024,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Gastrointestinal tumours overexpress voltage\u2010gated calcium (Ca<jats:sub>V<\/jats:sub>3) channels (Ca<jats:sub>V<\/jats:sub>3.1, 3.2 and 3.3). Ca<jats:sub>V<\/jats:sub>3 channels regulate cell growth and apoptosis colorectal cancer. Gossypol, a polyphenolic aldehyde found in the cotton plant, has anti\u2010tumour properties and inhibits Ca<jats:sub>V<\/jats:sub>3 currents. A systematic study was performed on gossypol blocking mechanism on Ca<jats:sub>V<\/jats:sub>3 channels and its potential anticancer effects in colon cancer cells, which express Ca<jats:sub>V<\/jats:sub>3 isoforms.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>Transcripts for Ca<jats:sub>V<\/jats:sub>3 proteins were analysed in gastrointestinal cancers using public repositories and in human colorectal cancer cell lines HCT116, SW480 and SW620. The gossypol blocking mechanism on Ca<jats:sub>V<\/jats:sub>3 channels was investigated by combining heterologous expression systems and patch\u2010clamp experiments. The anti\u2010tumoural properties of gossypol were estimated by cell proliferation, viability and cell cycle assays. Ca<jats:sup>2+<\/jats:sup> dynamics were evaluated with cytosolic and endoplasmic reticulum (ER) Ca<jats:sup>2+<\/jats:sup> indicators.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>High levels of Ca<jats:sub>V<\/jats:sub>3 transcripts correlate with poor prognosis in gastrointestinal cancers. Gossypol blockade of Ca<jats:sub>V<\/jats:sub>3 isoforms is concentration\u2010 and use\u2010dependent interacting with the closed, activated and inactivated conformations of Ca<jats:sub>V<\/jats:sub>3 channels. Gossypol and Ca<jats:sub>V<\/jats:sub>3 channels down\u2010regulation inhibit colorectal cancer cell proliferation by arresting cell cycles at the G<jats:sub>0<\/jats:sub>\/G<jats:sub>1<\/jats:sub> and G<jats:sub>2<\/jats:sub>\/M phases, respectively. Ca<jats:sub>V<\/jats:sub>3 channels underlie the vectorial Ca<jats:sup>2+<\/jats:sup> uptake by endoplasmic reticulum in colorectal cancer cells.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Implications<\/jats:title><jats:p>Gossypol differentially blocked Ca<jats:sub>V<\/jats:sub>3 channel and its anticancer activity was correlated with high levels of Ca<jats:sub>V<\/jats:sub>3.1 and Ca<jats:sub>V<\/jats:sub>3.2 in colorectal cancer cells. The Ca<jats:sub>V<\/jats:sub>3 regulates cell proliferation and Ca<jats:sup>2+<\/jats:sup> dynamics in colorectal cancer cells. Understanding this blocking mechanism maybe improve cancer therapies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.16497","type":"journal-article","created":{"date-parts":[[2024,7,31]],"date-time":"2024-07-31T07:18:53Z","timestamp":1722410333000},"page":"4546-4570","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Blockade of Ca<sub>V<\/sub>3 calcium channels and induction of G<sub>0<\/sub>\/G<sub>1<\/sub> cell cycle arrest in colon cancer cells by gossypol"],"prefix":"10.1111","volume":"181","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5080-8310","authenticated-orcid":false,"given":"Osbaldo","family":"Lopez\u2010Charcas","sequence":"first","affiliation":[{"name":"Departamento de Neuropatolog\u00eda Molecular, Divisi\u00f3n de Neurociencias, Instituto de Fisiolog\u00eda Celular Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oumnia","family":"Benouna","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tours, Inserm U1327 ISCHEMIA \u2018Membrane Signalling and Inflammation in Reperfusion Injuries\u2019  Tours France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roxane","family":"Lemoine","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tours, Inserm U1327 ISCHEMIA \u2018Membrane Signalling and Inflammation in Reperfusion Injuries\u2019  Tours France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarita Jacaranda","family":"Rosendo\u2010Pineda","sequence":"additional","affiliation":[{"name":"Departamento de Neuropatolog\u00eda Molecular, Divisi\u00f3n de Neurociencias, Instituto de Fisiolog\u00eda Celular Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-8029-6167","authenticated-orcid":false,"given":"Tonantzin Guadalupe","family":"Anguheven\u2010Ledezma","sequence":"additional","affiliation":[{"name":"Departamento de Neuropatolog\u00eda Molecular, Divisi\u00f3n de Neurociencias, Instituto de Fisiolog\u00eda Celular Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lizeth","family":"Sandoval\u2010Vazquez","sequence":"additional","affiliation":[{"name":"Department of Biochemistry CINVESTAV  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Martin Leonardo","family":"Gallegos\u2010Gomez","sequence":"additional","affiliation":[{"name":"Department of Biochemistry CINVESTAV  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leticia","family":"Robles\u2010Martinez","sequence":"additional","affiliation":[{"name":"Departamento de Neuropatolog\u00eda Molecular, Divisi\u00f3n de Neurociencias, Instituto de Fisiolog\u00eda Celular Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zazil","family":"Herrera\u2010Carrillo","sequence":"additional","affiliation":[{"name":"Departamento de Neuropatolog\u00eda Molecular, Divisi\u00f3n de Neurociencias, Instituto de Fisiolog\u00eda Celular Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"},{"name":"Centro de Investigaci\u00f3n en Ciencias de la Salud (CICSA) Universidad An\u00e1huac  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Miguel","family":"Ram\u00edrez\u2010Arag\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Neuropatolog\u00eda Molecular, Divisi\u00f3n de Neurociencias, Instituto de Fisiolog\u00eda Celular Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ana","family":"Alfaro","sequence":"additional","affiliation":[{"name":"Servicio de Anatom\u00eda Patol\u00f3gica Hospital General de M\u00e9xico \u2018Dr. Eduardo Liceaga\u2019  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"St\u00e9phanie","family":"Chadet","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tours, Inserm U1327 ISCHEMIA \u2018Membrane Signalling and Inflammation in Reperfusion Injuries\u2019  Tours France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2982-0024","authenticated-orcid":false,"given":"Fabio","family":"Ferro","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tours, Inserm U1327 ISCHEMIA \u2018Membrane Signalling and Inflammation in Reperfusion Injuries\u2019  Tours France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pierre","family":"Besson","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tours, Inserm U1327 ISCHEMIA \u2018Membrane Signalling and Inflammation in Reperfusion Injuries\u2019  Tours France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin\u2010Hua","family":"Jiang","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tours, Inserm U1327 ISCHEMIA \u2018Membrane Signalling and Inflammation in Reperfusion Injuries\u2019  Tours France"},{"name":"Department of Physiology and Pathophysiology and Sino\u2010UK Joint Laboratory of Brain Function and Injury of Henan Province Xinxiang Medical University  Xinxiang China"},{"name":"School of Biomedical Sciences, Faculty of Biological Sciences University of Leeds  Leeds UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sadanandan E.","family":"Velu","sequence":"additional","affiliation":[{"name":"Department of Chemistry University of Alabama at Birmingham  Birmingham Alabama USA"},{"name":"O'Neal Comprehensive Cancer Center University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Agust\u00edn","family":"Guerrero\u2010Hernandez","sequence":"additional","affiliation":[{"name":"Department of Biochemistry CINVESTAV  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S\u00e9bastien","family":"Roger","sequence":"additional","affiliation":[{"name":"Universit\u00e9 de Tours, Inserm U1327 ISCHEMIA \u2018Membrane Signalling and Inflammation in Reperfusion Injuries\u2019  Tours France"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan Carlos","family":"Gomora","sequence":"additional","affiliation":[{"name":"Departamento de Neuropatolog\u00eda Molecular, Divisi\u00f3n de Neurociencias, Instituto de Fisiolog\u00eda Celular Universidad Nacional Aut\u00f3noma de M\u00e9xico  Mexico City Mexico"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2024,7,31]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1021\/cr60208a002"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16181"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16178"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14112"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbcan.2020.188364"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2022.102610"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.antiviral.2012.02.014"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11020134"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00766687"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(02)01315-8"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12020391"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2019.11.014"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22052622"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2020.00544"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10549-018-4970-0"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.13.7627"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1550-7408.1983.tb05337.x"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2818.2006.01706.x"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj2950357"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1021\/ja01288a048"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-014-1489-z"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1038\/310501a0"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.12929"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0041-0101(01)00194-5"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.111.073205"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15868"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1158\/1541-7786.MCR-13-0485"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-15-0456"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182818"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2006.04.027"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00424-014-1446-x"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M707159200"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-35280-z"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-2952(84)90500-8"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-0751-8"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0182265"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00656997"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00276.2014"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.2002.88.1.196"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nox020"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S172948"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2017.07.006"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2010.09.020"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11060-012-0995-0"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-014-1235-1"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.1999.00849.x"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1089\/adt.2015.29014.ajkdrrr"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.19-06-01912.1999"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3495(99)77134-1"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10735-020-09937-x"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1039\/D1NP00080B"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31364-y"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.112.078923"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2007.03.006"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.4155\/fmc-2017-0046"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.15121"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes12091329"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M108754200"},{"issue":"1","key":"e_1_2_12_60_1","first-page":"302","article-title":"Mibefradil block of cloned T\u2010type calcium channels","volume":"295","author":"Martin R. L.","year":"2000","journal-title":"The Journal of Pharmacology and Experimental Therapeutics"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23179894"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.6750791"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.1987.sp016406"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14122624"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0320(19960501)24:1<55::AID-CYTO7>3.0.CO;2-H"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21093351"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00018.2002"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/36110"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15020144"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(17)42744-X"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-17-3061"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-022-02771-0"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.crbiot.2022.09.009"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12030461"},{"issue":"1","key":"e_1_2_12_75_1","first-page":"22","article-title":"Ion\u2010channels in human sperm membrane and contraceptive mechanisms of male antifertility compounds derived from Chinese traditional medicine","volume":"24","author":"Shi Y.\u2010L.","year":"2003","journal-title":"Acta Pharmacologica Sinica"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/pros.23879"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.24194"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms5153"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkx247"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2008.03.032"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.14.4984"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-18-1924"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2019.03.001"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24071286"},{"key":"e_1_2_12_85_1","first-page":"215","volume-title":"Advances in food and nutrition research","author":"Wang X.","year":"2009"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2014.12.021"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.1999.0720791.x"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2013.00185"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-16-2347"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.16497","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,10,8]],"date-time":"2024-10-08T02:58:54Z","timestamp":1728356334000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.16497"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,7,31]]},"references-count":88,"journal-issue":{"issue":"22","published-print":{"date-parts":[[2024,11]]}},"alternative-id":["10.1111\/bph.16497"],"URL":"https:\/\/doi.org\/10.1111\/bph.16497","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,7,31]]},"assertion":[{"value":"2023-10-05","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-06-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-07-31","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}