{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,15]],"date-time":"2026-07-15T14:24:56Z","timestamp":1784125496327,"version":"3.55.0"},"reference-count":185,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T00:00:00Z","timestamp":1728691200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:p>Inflammation has a pivotal role in the initiation and progression of various cancers, contributing to crucial processes such as metastasis, angiogenesis, cell proliferation and invasion. Moreover, the release of cytokines mediated by inflammation within the tumour microenvironment (TME) has a crucial role in orchestrating these events. The activation of inflammatory caspases, facilitated by the recruitment of caspase\u20101, is initiated by the activation of pattern recognition receptors on the immune cell membrane. This activation results in the production of proinflammatory cytokines, including IL\u20101\u03b2 and IL\u201018, and participates in diverse biological processes with significant implications. The NOD\u2010Like Receptor Protein 3 (NLRP3) inflammasome holds a central role in innate immunity and regulates inflammation through releasing IL\u20101\u03b2 and IL\u201018. Moreover, it interacts with various cellular compartments. Recently, the mechanisms underlying NLRP3 inflammasome activation have garnered considerable attention. Disruption in NLRP3 inflammasome activation has been associated with a spectrum of inflammatory diseases, encompassing diabetes, enteritis, neurodegenerative diseases, obesity and tumours. The NLRP3 impact on tumorigenesis varies across different cancer types, with contrasting roles observed. For example, colorectal cancer associated with colitis can be suppressed by NLRP3, whereas gastric and skin cancers may be promoted by its activity. This review provides comprehensive insights into the structure, biological characteristics and mechanisms of the NLRP3 inflammasome, with a specific focus on the relationship between NLRP3 and tumour\u2010related immune responses, and TME. Furthermore, the review explores potential strategies for targeting cancers via NLRP3 inflammasome modulation. This encompasses innovative approaches, including NLRP3\u2010based nanoparticles, gene\u2010targeted therapy and immune checkpoint inhibitors.<\/jats:p>","DOI":"10.1111\/bph.17352","type":"journal-article","created":{"date-parts":[[2024,10,12]],"date-time":"2024-10-12T09:26:01Z","timestamp":1728725161000},"page":"3-25","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Breaking the barriers: Overcoming cancer resistance by targeting the NLRP3 inflammasome"],"prefix":"10.1111","volume":"182","author":[{"given":"Nazanin","family":"Pazhouhesh Far","sequence":"first","affiliation":[{"name":"Department of Microbiology, Faculty of Advanced Science and Technology, Tehran Medical Science Islamic Azad University  Tehran Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahsa","family":"Hajiheidari Varnousafaderani","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Debrecen  Debrecen Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ferdos","family":"Faghihkhorasani","sequence":"additional","affiliation":[{"name":"Medical Campus, Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sareh","family":"Etemad","sequence":"additional","affiliation":[{"name":"Department of Pathology, Faculty of Anatomical Pathology, Ghaem Hospital University of Medicine  Mashhad Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Al\u2010Hasnawi Rasool Riyadh","family":"Abdulwahid","sequence":"additional","affiliation":[{"name":"Medical Campus, Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Negar","family":"Bakhtiarinia","sequence":"additional","affiliation":[{"name":"Medical Campus, Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Afsaneh","family":"Mousaei","sequence":"additional","affiliation":[{"name":"Department of Biology College of Science, Qaemshahr Branch, Islamic Azad University  Qaem Shahr Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elahe","family":"Dortaj","sequence":"additional","affiliation":[{"name":"Department of Ergonomics, School of Health Shiraz University of Medical Sciences  Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Soroush","family":"Karimi","sequence":"additional","affiliation":[{"name":"Nano Drug Delivery Research Center, Health Technology Institute Kermanshah University of Medical Sciences  Kermanshah Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nasim","family":"Ebrahimi","sequence":"additional","affiliation":[{"name":"Genetics Division, Department of Cell and Molecular Biology and Microbiology, Faculty of Science and Technology University of Isfahan  Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir Reza","family":"Aref","sequence":"additional","affiliation":[{"name":"Mass General Cancer Center, Department of Surgery, Massachusetts General Hospital Harvard Medical School  Boston Massachusetts USA"},{"name":"Broad Institute of MIT and Harvard  Cambridge Massachusetts USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,12]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-20-1610"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2013.03.027"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.3390\/plants12122350"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15538"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15540"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15540"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15539"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12366"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20100050"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13346-018-0551-3"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.11.079"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2017.09.004"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2021.11.011"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M200497200"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5522964"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.16903"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2016-07-730556"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1021\/mp900278x"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-018-0014-x"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnagi.2022.879021"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes13081370"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.2337\/dc11-2219"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2023.1173235"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2873"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-018-0761-3"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.23208"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms13193"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-023-00462-9"},{"key":"e_1_2_16_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms231911678"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-12-0509"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-020-00936-9"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0277-7"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3806"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrclinonc.2015.105"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2004.05.074"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phymed.2022.154249"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01924"},{"key":"e_1_2_16_39_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20161707"},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-2080"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-10-1921"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10555-010-9229-0"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108512"},{"key":"e_1_2_16_44_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1209171109"},{"key":"e_1_2_16_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-12370-8"},{"key":"e_1_2_16_46_1","doi-asserted-by":"publisher","DOI":"10.1089\/jir.2014.0026"},{"key":"e_1_2_16_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.11.013"},{"key":"e_1_2_16_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21124223"},{"key":"e_1_2_16_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2017.07.075"},{"key":"e_1_2_16_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.03.037"},{"key":"e_1_2_16_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.06.025"},{"key":"e_1_2_16_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.565924"},{"key":"e_1_2_16_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep36107"},{"key":"e_1_2_16_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3893"},{"key":"e_1_2_16_55_1","doi-asserted-by":"publisher","DOI":"10.4161\/auto.28374"},{"key":"e_1_2_16_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2014.11.008"},{"key":"e_1_2_16_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.critrevonc.2013.03.010"},{"key":"e_1_2_16_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07573-4"},{"key":"e_1_2_16_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15497-1"},{"key":"e_1_2_16_60_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01444"},{"key":"e_1_2_16_61_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-020-00589-8"},{"key":"e_1_2_16_62_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2014.00352"},{"issue":"2","key":"e_1_2_16_63_1","first-page":"A24","article-title":"22 Activity of the tumor\u2010intrinsic NLRP3 inflammasome pathway predicts for response to checkpoint inhibitor immunotherapy in melanoma patients","volume":"10","author":"Haykal T.","year":"2022","journal-title":"Journal for Immunotherapy of Cancer"},{"key":"e_1_2_16_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-04947-6"},{"key":"e_1_2_16_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-023-03229-7"},{"key":"e_1_2_16_66_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep28370"},{"key":"e_1_2_16_67_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04467-w"},{"key":"e_1_2_16_68_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.12289"},{"key":"e_1_2_16_69_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1128700"},{"key":"e_1_2_16_70_1","doi-asserted-by":"publisher","DOI":"10.3389\/fbioe.2023.1110765"},{"key":"e_1_2_16_71_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41423-021-00740-6"},{"key":"e_1_2_16_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11535"},{"key":"e_1_2_16_73_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12020433"},{"key":"e_1_2_16_74_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1474319"},{"key":"e_1_2_16_75_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20171419"},{"key":"e_1_2_16_76_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2015.95"},{"key":"e_1_2_16_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2007.78"},{"key":"e_1_2_16_78_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01132"},{"key":"e_1_2_16_79_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1812266115"},{"key":"e_1_2_16_80_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature15541"},{"key":"e_1_2_16_81_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0900476"},{"key":"e_1_2_16_82_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20133328"},{"key":"e_1_2_16_83_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01660-7"},{"key":"e_1_2_16_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2665-9913(20)30065-5"},{"key":"e_1_2_16_85_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13277-015-3473-4"},{"key":"e_1_2_16_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.04.007"},{"key":"e_1_2_16_87_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20180589"},{"key":"e_1_2_16_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-48794-x"},{"key":"e_1_2_16_89_1","doi-asserted-by":"publisher","DOI":"10.1530\/ERC-19-0482"},{"key":"e_1_2_16_90_1","doi-asserted-by":"publisher","DOI":"10.1136\/annrheumdis-2013-204991"},{"key":"e_1_2_16_91_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmaa155"},{"key":"e_1_2_16_92_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.381"},{"key":"e_1_2_16_93_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.839041"},{"key":"e_1_2_16_94_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1320294111"},{"key":"e_1_2_16_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines9020136"},{"key":"e_1_2_16_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2020.106829"},{"key":"e_1_2_16_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/sigtrans.2017.23"},{"key":"e_1_2_16_98_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2013.03.008"},{"key":"e_1_2_16_99_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-017-0031-6"},{"key":"e_1_2_16_100_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.634118"},{"key":"e_1_2_16_101_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-15-1655"},{"key":"e_1_2_16_102_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aas8995"},{"key":"e_1_2_16_103_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2013.00248"},{"key":"e_1_2_16_104_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.207365"},{"key":"e_1_2_16_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2023.122062"},{"key":"e_1_2_16_106_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-10626-x"},{"key":"e_1_2_16_107_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07201"},{"key":"e_1_2_16_108_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13102297"},{"key":"e_1_2_16_109_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40259-017-0224-7"},{"issue":"12","key":"e_1_2_16_110_1","first-page":"1021","article-title":"Role of cyclin D1 in breast carcinoma","volume":"18","author":"Mohammadizadeh F.","year":"2013","journal-title":"Journal of Research in Medical Sciences: The Official Journal of Isfahan University of Medical Sciences"},{"key":"e_1_2_16_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2013.05.016"},{"key":"e_1_2_16_112_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1117765109"},{"key":"e_1_2_16_113_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.202006599"},{"key":"e_1_2_16_114_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160027"},{"key":"e_1_2_16_115_1","doi-asserted-by":"publisher","DOI":"10.1042\/CS20210865"},{"key":"e_1_2_16_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2017.10.003"},{"key":"e_1_2_16_117_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.8594"},{"key":"e_1_2_16_118_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114385"},{"key":"e_1_2_16_119_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tiv.2022.105350"},{"key":"e_1_2_16_120_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2015.07.012"},{"key":"e_1_2_16_121_1","doi-asserted-by":"publisher","DOI":"10.1002\/anie.201508288"},{"key":"e_1_2_16_122_1","doi-asserted-by":"publisher","DOI":"10.1093\/pcmedi\/pbz019"},{"key":"e_1_2_16_123_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12011-022-03229-z"},{"key":"e_1_2_16_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(17)32247-X"},{"key":"e_1_2_16_125_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1032-7"},{"key":"e_1_2_16_126_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2014.06.020"},{"key":"e_1_2_16_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semradonc.2014.07.007"},{"key":"e_1_2_16_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.01.040"},{"key":"e_1_2_16_129_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c01307"},{"key":"e_1_2_16_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2019.04.003"},{"key":"e_1_2_16_131_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.22809"},{"key":"e_1_2_16_132_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-023-01235-9"},{"key":"e_1_2_16_133_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4939-7352-1_12"},{"key":"e_1_2_16_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41590-021-00886-5"},{"key":"e_1_2_16_135_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM199911183412102"},{"key":"e_1_2_16_136_1","doi-asserted-by":"publisher","DOI":"10.1158\/1535-7163.MCT-17-0823"},{"key":"e_1_2_16_137_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.01587"},{"key":"e_1_2_16_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.09.007"},{"key":"e_1_2_16_139_1","doi-asserted-by":"publisher","DOI":"10.1002\/smll.201201962"},{"key":"e_1_2_16_140_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.1051612"},{"key":"e_1_2_16_141_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_16_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-019-0278-6"},{"key":"e_1_2_16_143_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15050574"},{"key":"e_1_2_16_144_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2000915118"},{"key":"e_1_2_16_145_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI133055"},{"key":"e_1_2_16_146_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13194753"},{"key":"e_1_2_16_147_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22010426"},{"key":"e_1_2_16_148_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgab008"},{"key":"e_1_2_16_149_1","doi-asserted-by":"publisher","DOI":"10.1093\/carcin\/bgs256"},{"key":"e_1_2_16_150_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1730-1"},{"key":"e_1_2_16_151_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2012.01008.x"},{"key":"e_1_2_16_152_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abe2888"},{"key":"e_1_2_16_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2016.03.009"},{"key":"e_1_2_16_154_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00333"},{"key":"e_1_2_16_155_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12672-023-00701-7"},{"key":"e_1_2_16_156_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22393"},{"key":"e_1_2_16_157_1","doi-asserted-by":"publisher","DOI":"10.3892\/or.2016.4569"},{"key":"e_1_2_16_158_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1116532"},{"key":"e_1_2_16_159_1","doi-asserted-by":"publisher","DOI":"10.1038\/labinvest.2013.126"},{"key":"e_1_2_16_160_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.634607"},{"key":"e_1_2_16_161_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20160392"},{"key":"e_1_2_16_162_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-19-3176"},{"key":"e_1_2_16_163_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.10317"},{"key":"e_1_2_16_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.taap.2014.10.002"},{"key":"e_1_2_16_165_1","doi-asserted-by":"publisher","DOI":"10.7314\/APJCP.2016.17.2.667"},{"key":"e_1_2_16_166_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2017.04.037"},{"key":"e_1_2_16_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-06522-5"},{"key":"e_1_2_16_168_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-019-0755-0"},{"key":"e_1_2_16_169_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2019.00588"},{"key":"e_1_2_16_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.it.2019.09.005"},{"key":"e_1_2_16_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.csbj.2023.03.017"},{"key":"e_1_2_16_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2012.06.016"},{"key":"e_1_2_16_173_1","doi-asserted-by":"publisher","DOI":"10.1038\/cmi.2016.29"},{"key":"e_1_2_16_174_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms20030649"},{"key":"e_1_2_16_175_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12008"},{"key":"e_1_2_16_176_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.18619"},{"key":"e_1_2_16_177_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02538"},{"key":"e_1_2_16_178_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1002046"},{"key":"e_1_2_16_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humimm.2017.10.013"},{"key":"e_1_2_16_180_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.21010"},{"key":"e_1_2_16_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41385-019-0177-x"},{"key":"e_1_2_16_182_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20200730"},{"key":"e_1_2_16_183_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2015.12.057"},{"key":"e_1_2_16_184_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMc1412035"},{"key":"e_1_2_16_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2019.03.009"},{"key":"e_1_2_16_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2018.09.051"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.17352","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,3]],"date-time":"2024-12-03T00:22:06Z","timestamp":1733185326000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.17352"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,12]]},"references-count":185,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/bph.17352"],"URL":"https:\/\/doi.org\/10.1111\/bph.17352","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,12]]},"assertion":[{"value":"2023-11-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-08-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}