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In this study, we have determined the treatment effects of immunomodulatory drugs on FM.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>\n                      FM was induced in A\/JGpt mice by intraperitoneal administration of coxsackievirus B3, after which immunoglobins were administered daily by intraperitoneal injection. On the seventh day, the cardiac structure and function were determined using echocardiography and cardiac catheterisation. Single\u2010cell RNA sequencing (scRNA\u2010seq) was performed to evaluate CD45\n                      <jats:sup>+<\/jats:sup>\n                      cells in the heart.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Immunoglobin, a typical immunomodulatory drug, dramatically reduced mortality and significantly improved cardiac function in mice with FM. ScRNA\u2010seq revealed that immunoglobin treatment effectively modulated cardiac immune homeostasis, particularly by attenuating overactivated innate immune responses. At the cellular level, immunoglobin predominantly targeted Plac8\n                      <jats:sup>+<\/jats:sup>\n                      monocytes and S100a8\n                      <jats:sup>+<\/jats:sup>\n                      neutrophils, suppressing their proinflammatory activities, and enhancing antigen processing and presentation capabilities, thereby amplifying the efficiency and potency of the immune response against the virus. Immunoglobin benefits are mediated by the modulation of multiple signalling pathways, including relevant receptors on immune cells, direction of inflammatory cell chemotaxis, antigen presentation and anti\u2010viral effects. Subsequently,\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"https:\/\/www.guidetopharmacology.org\/GRAC\/ObjectDisplayForward?objectId=2896\">Bst2-ILT7<\/jats:ext-link>\n                      ligand\u2010receptor\u2010mediated cellular interactions manipulated by immunoglobin were further confirmed in vivo.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications<\/jats:title>\n                    <jats:p>Immunoglobin treatment significantly attenuated FM\u2010induced cardiac inflammation and improved cardiac function by inhibiting overactivated innate immune responses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>LINKED ARTICLES<\/jats:title>\n                    <jats:p>\n                      This article is part of a themed issue Drugs and Drug Targets in Metabolic and Chronic Inflammatory Diseases. To view the other articles in this section visit\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v182.20\/issuetoc\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/bph.v182.20\/issuetoc<\/jats:ext-link>\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.17372","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T19:01:04Z","timestamp":1729710064000},"page":"4984-5003","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Immunoglobin attenuates fulminant myocarditis by inhibiting overactivated innate immune response"],"prefix":"10.1111","volume":"182","author":[{"given":"Jianpei","family":"Wen","sequence":"first","affiliation":[{"name":"Division of Cardiology, Tongji Hospital, Tongji Medical College and State Key Laboratory for Diagnosis and 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