{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T15:59:22Z","timestamp":1790351962846,"version":"4.1.0"},"reference-count":214,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T00:00:00Z","timestamp":1729641600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP24K01965"],"award-info":[{"award-number":["JP24K01965"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["202208420023"],"award-info":[{"award-number":["202208420023"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009708","name":"Novo Nordisk Fonden","doi-asserted-by":"publisher","award":["NNF20OC0062899"],"award-info":[{"award-number":["NNF20OC0062899"]}],"id":[{"id":"10.13039\/501100009708","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004836","name":"Danmarks Frie Forskningsfond","doi-asserted-by":"publisher","award":["DFF1: 6110\u201000688B"],"award-info":[{"award-number":["DFF1: 6110\u201000688B"]}],"id":[{"id":"10.13039\/501100004836","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["682549"],"award-info":[{"award-number":["682549"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003554","name":"Lundbeck Foundation","doi-asserted-by":"publisher","award":["R242\u20102017\u2010409"],"award-info":[{"award-number":["R242\u20102017\u2010409"]}],"id":[{"id":"10.13039\/501100003554","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2025,1]]},"abstract":"<jats:p>\n                    G protein\u2010coupled receptors (GPCRs) are pivotal in cellular signalling and drug targeting. Herpesviruses encode GPCRs (vGPCRs) to manipulate cellular signalling, thereby regulating various aspects of the virus life cycle, such as viral spreading and immune evasion.\u00a0vGPCRs mimic host chemokine receptors, often with broader signalling and high constitutive activity. This review focuses on the recent advancements in structural knowledge about vGPCRs, with an emphasis on molecular mechanisms of action and ligand binding. The structures of US27 and US28 from human cytomegalovirus (HCMV) are compared to their closest human homologue, CX\n                    <jats:sub>3<\/jats:sub>\n                    CR1. Contrasting US27 and US28, the homotrimeric UL78 structure (HCMV) reveals more distance to chemokine receptors. Open reading frame 74 (ORF74; Kaposi's sarcoma\u2010associated herpesvirus) is compared to CXCRs, whereas BILF1 (Epstein\u2013Barr virus) is discussed as a putative lipid receptor. Furthermore, the roles\u00a0of vGPCRs in latency and lytic replication, reactivation, dissemination and immune evasion are\u00a0reviewed, together with their potential as drug targets for virus infections and virus\u2010related diseases.\n                  <\/jats:p>","DOI":"10.1111\/bph.17379","type":"journal-article","created":{"date-parts":[[2024,10,23]],"date-time":"2024-10-23T23:53:40Z","timestamp":1729727620000},"page":"26-51","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Insight into structural properties of viral G protein\u2010coupled receptors and their role in the viral infection: IUPHAR Review 41"],"prefix":"10.1111","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3617-7145","authenticated-orcid":false,"given":"Naotaka","family":"Tsutsumi","sequence":"first","affiliation":[{"name":"TMDU Advanced Research Institute Tokyo Medical and Dental University  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dagmar F\u00e6ster","family":"Kildedal","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Copenhagen  Copenhagen Denmark"},{"name":"Synklino ApS  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia Kramer","family":"Hansen","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qianqian","family":"Kong","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dominique","family":"Schols","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tom","family":"Van Loy","sequence":"additional","affiliation":[{"name":"Laboratory of Virology and Chemotherapy, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research KU Leuven  Leuven Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9600-3254","authenticated-orcid":false,"given":"Mette Marie","family":"Rosenkilde","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences University of Copenhagen  Copenhagen Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,10,23]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.coviro.2016.07.008"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-024-07487-w"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)36831-0"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.09.002"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16177"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.119.117168"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/385347a0"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2019.12.003"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-018-0160-y"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.2218\/gtopdb\/F14\/2023.1"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.113.007724"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1038\/34193"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04575-7"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.9.7218-7230.1999"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.1.441-449.2005"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.3.2352-2363.1998"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1135280"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.7.5535-5544.1998"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01006-14"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V94.6.1899"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1093\/ajh\/hpad045"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.3390\/v15030711"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2005.12.011"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2009.07.002"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa5026"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.onc.1207021"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00386-09"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M306530200"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M210033200"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407536200"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02550-06"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1002\/eji.200737618"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2023.10.029"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1101\/2023.07.18.549504"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-024-00684-x"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1710522114"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0042-6822(03)00006-0"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2020.03.003"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01889-19"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.2217\/fvl.13.7"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.3390\/v14020391"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.2.1521-1529.1997"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24574-y"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24608-5"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.120.000186"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.molpharmaceut.9b00360"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(20)79672-9"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0124486"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.11817"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp-2014-307727"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2008.20.7209"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2008-08-174946"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1128\/AAC.49.11.4721-4732.2005"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2004.07.076"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-018-0170-9"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01707-18"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.03406-12"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02113-10"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.015222"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1091\/mbc.12.6.1737"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2003.00079.x"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0854.2002.030307.x"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-016-0154-x"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0805098105"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(19)61936-8"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010919-023545"},{"key":"e_1_2_10_68_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1998.9557"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI4461"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2016.02.007"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1102462"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.4.2631-2639.2003"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd.2017.178"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0255-7"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI13622"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2216329120"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-1953-1"},{"key":"e_1_2_10_78_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm050418d"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02507-15"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1006968"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abg8685"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2014.11.001"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.72.7.6104-6112.1998"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-39799-2"},{"key":"e_1_2_10_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2019.07.028"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.174.6.3686"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.02156"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03819-2"},{"key":"e_1_2_10_89_1","doi-asserted-by":"publisher","DOI":"10.1042\/BST20230358"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.277.5332.1656"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-5793(98)01551-8"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13164079"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa1080"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1816933116"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/v10080445"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1128\/mBio.01754-17"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms14321"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.254268"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.1995.1814"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.170.1.243"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-36575-0"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1101\/2023.12.27.573477"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-020-2492-5"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-021-00841-3"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aao6152"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abn8048"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1111\/cbdd.12848"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2010.173"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01867-21"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0604433103"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.3389\/fendo.2022.862940"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25235710"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virol.2004.04.027"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1011682"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.16.10788-10795.2005"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.78.15.8382-8391.2004"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.73.1.325-333.1999"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1099\/vir.0.80436-0"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.35850"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M303219200"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.164.5.2396"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2020.00368"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41592-022-01488-1"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010510-100608"},{"issue":"6","key":"e_1_2_10_125_1","first-page":"2641","article-title":"The Kaposi's sarcoma\u2010associated herpesvirus G protein\u2010coupled receptor promotes endothelial cell survival through the activation of Akt\/protein kinase B","volume":"61","author":"Montaner S.","year":"2001","journal-title":"Cancer Research"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2003-12-4436"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0042-6822(02)00023-5"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-018-0171-8"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.77.14.8108-8115.2003"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000656"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M110.115618"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02442-10"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.05900-11"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.051629898"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nov189"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkac1013"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.75.18.8660-8673.2001"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.1.536-546.2005"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-022-03414-4"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1514921"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.70.12.8833-8849.1996"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.2217\/imt.14.94"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.healun.2021.10.010"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M602245200"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.106.027425"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.2.956"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M003800200"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.105.011239"},{"key":"e_1_2_10_149_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M313392200"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.57.3.602"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-virology-100220-113942"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02052-08"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01399-09"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.meegid.2017.03.013"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2011.01551.x"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.167.1.505"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-021-00918-z"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41421-022-00403-4"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.1186\/1743-422X-4-87"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M104783200"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.76.4.1744-1752.2002"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0400835101"},{"issue":"17","key":"e_1_2_10_163_1","first-page":"4873","article-title":"The Kaposi's sarcoma\u2010associated herpes virus G protein\u2010coupled receptor up\u2010regulates vascular endothelial growth factor expression and secretion through mitogen\u2010activated protein kinase and p38 pathways acting on hypoxia\u2010inducible factor 1\u03b1","volume":"60","author":"Sodhi A.","year":"2000","journal-title":"Cancer Research"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-11-0744"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02716-14"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1509392112"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaa7998"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11262-024-02054-x"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature18636"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2014.00277"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1038\/nbt.3988"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M114.548131"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.2174\/1568005014606080"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0092-8674(00)81539-1"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.270.45.27348"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.00354-09"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.11.7068-7076.2005"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2011-08-372516"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1006209"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature23448"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41587-021-01156-3"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.ccr-0670-3"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-018-0131-3"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2011.06.009"},{"key":"e_1_2_10_185_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.abl5442"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.06.001"},{"key":"e_1_2_10_187_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jcim.3c01835"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.3c00352"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.RA119.007796"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.3390\/v12060594"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2020.104804"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.78.7.3343-3351.2004"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M606877200"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.74.16.7656-7665.2000"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.71.8.5894-5904.1997"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4189"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00705-012-1246-6"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.1099\/0022-1317-82-5-1187"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M213179200"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.1128\/jvi.76.16.8161-8168.2002"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2018.08.009"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-16820-6"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.1047299"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.191.3.445"},{"key":"e_1_2_10_205_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2023.05.018"},{"key":"e_1_2_10_206_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11701"},{"key":"e_1_2_10_207_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-021-24438-5"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature22035"},{"key":"e_1_2_10_209_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01803-6"},{"key":"e_1_2_10_210_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.79.18.11914-11924.2005"},{"key":"e_1_2_10_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2017.05.002"},{"key":"e_1_2_10_212_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.50279"},{"key":"e_1_2_10_213_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41564-018-0131-9"},{"key":"e_1_2_10_214_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.ppat.1000255"},{"key":"e_1_2_10_215_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.01608-10"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.17379","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,12,2]],"date-time":"2024-12-02T19:21:36Z","timestamp":1733167296000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.17379"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,10,23]]},"references-count":214,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,1]]}},"alternative-id":["10.1111\/bph.17379"],"URL":"https:\/\/doi.org\/10.1111\/bph.17379","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,10,23]]},"assertion":[{"value":"2024-07-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-09-14","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2024-10-23","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}