{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T16:14:00Z","timestamp":1777392840636,"version":"3.51.4"},"reference-count":49,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2024,11,3]],"date-time":"2024-11-03T00:00:00Z","timestamp":1730592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>In male rats, the serotonergic system modulates sympathetic outflow at vascular levels, causing sympatho\u2010inhibition and sympatho\u2010excitation, mainly via 5\u2010HT<jats:sub>1D\/1A<\/jats:sub> and 5\u2010HT<jats:sub>3<\/jats:sub> receptors, respectively. However, sex influence on vascular serotonergic regulation has not yet been elucidated. This study aimed to analyse the 5\u2010HT sympatho\u2010modulatory role in female rats, characterising the 5\u2010HT receptors involved.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>Female Wistar (14\u2010 to 16\u2010week\u2010old) rats were prepared for sympathetic stimulation. Mean blood pressure (MBP) and heart rate (HR) were continuously measured. Vasopressor responses were obtained by electrical stimulation of the sympathetic outflow (0.1\u20135\u2009Hz) or i.v. noradrenaline (0.01\u20130.5\u2009\u03bcg\u00b7kg<jats:sup>\u22121<\/jats:sup>). 5\u2010HT\u2010related drug effects on adrenergic system were determined. Age\u2010matched male rats were used as control.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Basal MBP in females was lower than in male rats, whereas electrical\u2010induced increases in MBP were similar. In females, 5\u2010HT exerted a dose\u2010dependent inhibition on the sympathetic\u2010evoked vasoconstrictions, that was reproduced by some agonists; 5\u2010CT (5\u2010HT<jats:sub>1\/5\/7<\/jats:sub>) and L\u2010694,247 (5\u2010HT<jats:sub>1D<\/jats:sub>), whereas the selective 5\u2010HT<jats:sub>2A\/2B\/2C<\/jats:sub> (<jats:italic>\u03b1<\/jats:italic>\u2010methyl\u20105\u2010HT) and 5\u2010HT<jats:sub>3<\/jats:sub> agonist (1\u2010PBG) increased the electrically\u2010produced vasopressor responses. None of the other drugs tested (targeting 5\u2010HT<jats:sub>1A\/1B\/1F<\/jats:sub>, 5\u2010HT<jats:sub>2B\/2C<\/jats:sub>, 5\u2010HT<jats:sub>4<\/jats:sub>, 5\u2010HT<jats:sub>5A<\/jats:sub> or 5\u2010HT<jats:sub>7<\/jats:sub>) modified these vasoconstrictions. Only 1\u2010PBG (5\u2010HT<jats:sub>3<\/jats:sub>) modified the vasoconstrictions induced by exogenous noradrenaline.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Implications<\/jats:title><jats:p>In female rats, vascular serotonergic sympatholytic effects are due to prejunctional 5\u2010HT<jats:sub>1D<\/jats:sub> receptor activation, whereas pre and\/or postjunctional 5\u2010HT<jats:sub>3<\/jats:sub> and prejunctional 5\u2010HT<jats:sub>2A<\/jats:sub> receptor activation is involved in the potentiating effect of vascular sympathetic neurotransmission. These findings may open novel sex\u2010differential therapeutic strategies for treating cardiovascular conditions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.17380","type":"journal-article","created":{"date-parts":[[2024,11,4]],"date-time":"2024-11-04T02:28:29Z","timestamp":1730687309000},"page":"1025-1037","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Sex influence on serotonergic modulation of the vascular noradrenergic drive in rats"],"prefix":"10.1111","volume":"182","author":[{"given":"Ana\u00efs Clara","family":"Terol\u2010\u00dabeda","sequence":"first","affiliation":[{"name":"Laboratorio de Farmacolog\u00eda. 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