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This paper reviews the major findings regarding these genetic variabilities that modulate responses to anti\u2010hypertensive therapies such as angiotensin converting enzyme (ACE) inhibitors, angiotensin receptor blockers (ARBs), diuretics, calcium channel blockers (CCBs) and \u03b2\u2010adrenoceptor blockers. The importance of studying these genetic polymorphisms stems from the goal to optimise anti\u2010hypertensive therapy for each individual patient, aiming for the highest efficacy and lowest risk of adverse effects. It is important to recognise that environmental and epigenetic factors can contribute to the observed variations in drug responses. Owing to the multigenic and multifactorial nature of drug responses, further research is crucial for translating these findings into clinical practice and the establishment of reliable recommendations.<\/jats:p>","DOI":"10.1111\/bph.17414","type":"journal-article","created":{"date-parts":[[2024,12,4]],"date-time":"2024-12-04T03:30:42Z","timestamp":1733283042000},"page":"929-950","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Genetic polymorphisms influencing antihypertensive drug responses"],"prefix":"10.1111","volume":"182","author":[{"given":"Jana","family":"El Cheikh","sequence":"first","affiliation":[{"name":"Faculty of Medicine University of Balamand, Al Koura  Tripoli Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fouad","family":"Hamed","sequence":"additional","affiliation":[{"name":"Faculty of Medicine University of Balamand, Al Koura  Tripoli 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