{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T14:53:43Z","timestamp":1789570423112,"version":"build-2803163510"},"reference-count":42,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T00:00:00Z","timestamp":1734220800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82202008"],"award-info":[{"award-number":["82202008"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20221029"],"award-info":[{"award-number":["BK20221029"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Stimulator of interferon response cGAMP interactor 1 (STING), a central hub protein of cyclic GMP\u2010AMP synthase (cGAS)\u2013STING signalling pathway, has a crucial role in regulating type I interferons (IFNs) production and response. Recent studies indicate that excessive activation of STING is strongly associated with autoimmune diseases, including systemic lupus erythematosus (SLE). Searching immunomodulators that negatively regulate STING might greatly contribute to the suppression of autoimmunity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>\n                      The peripheral blood mononuclear cells (PBMCs) of SLE patients, Hela cells, L929 cells and bone marrow\u2010derived macrophages (BMDMs) from mice were used as\n                      <jats:italic>in vitro<\/jats:italic>\n                      models. While, Trex1 KO mouse autoimmune disease model was used as\n                      <jats:italic>in vivo<\/jats:italic>\n                      model. After treatment with cordycepin, a nucleoside from Cordyceps mushrooms, type I IFNs production and response were determined by western blotting, real\u2010time polymerase chain reaction (PCR), dual\u2010luciferase assay, enzyme\u2010linked immunosorbent assay (ELISA), haematoxylin\u2013eosin staining and RNA\u2010seq.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Cordycepin inhibited type I IFNs production and response in human and murine systems following cGAS\u2013STING signalling activation. Importantly, cordycepin markedly attenuates the autoinflammatory and autoimmune responses in\n                      <jats:italic>Trex1<\/jats:italic>\n                      KO BMDMs and\n                      <jats:italic>Trex1<\/jats:italic>\n                      KO mice. Furthermore, cordycepin effectively suppressed the production of type I IFNs and interferon\u2010stimulated genes (\n                      <jats:italic>ISG<\/jats:italic>\n                      s) in the PBMCs of SLE patients. Mechanistically, cordycepin promoted STING degradation via autophagy pathway upon DNA stimulation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Implications<\/jats:title>\n                    <jats:p>This study shows that cordycepin promotes STING autophagic degradation to alleviate autoimmunity upon DNA stimulation. Cordycepin might be a potential therapeutic candidate for alleviating aberrant type I IFNs in autoimmune and autoinflammatory diseases.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.17425","type":"journal-article","created":{"date-parts":[[2024,12,15]],"date-time":"2024-12-15T19:59:41Z","timestamp":1734292781000},"page":"1546-1560","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Cordycepin ameliorates autoimmunity by promoting STING degradation via autophagy pathway"],"prefix":"10.1111","volume":"182","author":[{"given":"Daidi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Ophthalmology The First People's Hospital of Wuhu  Wuhu China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Niannian","family":"Peng","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jiangsu Food and Pharmaceutical Science College  Huaian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongqian","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology China Pharmaceutical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zuocheng","family":"Qiu","sequence":"additional","affiliation":[{"name":"Guangdong Provincial Key Laboratory of Speed Capability Research, School of Traditional Chinese Medicine Jinan University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lingxiao","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Rheumatology The First Affiliated Hospital of Nanjing Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-8030-5979","authenticated-orcid":false,"given":"Mingyu","family":"Pan","sequence":"additional","affiliation":[{"name":"School of Life Science and Technology China Pharmaceutical University  Nanjing China"},{"name":"Department of Biomedical Science City University of Hong Kong  Kowloon Hong Kong"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2024,12,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16179"},{"issue":"2","key":"e_1_2_13_3_1","first-page":"S1","article-title":"The concise guide to PHARMACOLOGY 2023\/24: Introduction and other protein targets","volume":"180","author":"Alexander S. 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