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Recent studies demonstrate that their function can be modulated by different pharmacological approaches. In this study, we focussed on the effects of systemically administered prostaglandin EP<jats:sub>4<\/jats:sub> receptor agonist L\u2010902,688 and pegylated human Arginase\u20101 on MDSCs in a murine model of chronic asthma and asthma exacerbation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>BALB\/c mice were challenged with house dust mite (HDM) over a period of 5\u2009weeks, establishing a chronic asthma phenotype. To induce asthma exacerbation, mice were infected with Influenza Virus H1N1 A\/Puerto Rico\/8\/1934. In vivo lung function, lung inflammatory features, number and suppressive activity of MDSCs, number of different T cell subsets in lung and spleen and viral titer in the bronchoalveolar lavage fluid (BALF) were assessed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>In asthmatic mice, treatment with the EP<jats:sub>4<\/jats:sub> receptor agonist or Arginase\u20101 significantly reduced the number of eosinophils in the BALF. Both treatments improved lung function and ameliorated airway hyperresponsiveness (AHR) in asthma exacerbation. The number and suppressive activity of MDSCs in the lung were increased\u00a0by virus\u2010induced asthma exacerbation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Implications<\/jats:title><jats:p>We found beneficial effects of systemic EP<jats:sub>4<\/jats:sub> receptor agonist and Arginase\u20101 therapy in a\u00a0murine model of chronic asthma and influenza virus\u2010induced asthma exacerbation. Our findings highlight the potential efficacy of EP<jats:sub>4<\/jats:sub> receptor agonists, Arginase\u20101, and MDSCs, as novel therapeutic approaches in asthma and asthma exacerbation.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.17473","type":"journal-article","created":{"date-parts":[[2025,3,12]],"date-time":"2025-03-12T09:35:29Z","timestamp":1741772129000},"page":"2803-2820","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Systemic EP4 receptor agonist and Arginase\u20101 therapy in a murine model of chronic asthma and influenza virus\u2010induced asthma exacerbation"],"prefix":"10.1111","volume":"182","author":[{"given":"Tim","family":"Lange","sequence":"first","affiliation":[{"name":"German Center for Lung Research (DZL), Universities of Giessen and Marburg Lung Center (UGMLC) Philipps University Marburg  Marburg 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