{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T02:23:11Z","timestamp":1783736591924,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T00:00:00Z","timestamp":1745798400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:sec><jats:title>Background and Purpose<\/jats:title><jats:p>Psoriasis is a multisystem inflammatory disease with a significant impact on quality of life. <jats:italic>Stellera chamaejasme<\/jats:italic>, a medicinal plant used in traditional Chinese medicine, shows promise for the treatment of psoriasis. We identified diterpenoids in <jats:italic>S.\u00a0chamaejasme<\/jats:italic>, including a new compound, stellchamain A (SA, <jats:bold>1<\/jats:bold>), with notable antipsoriasis properties. This study explored the effects of SA on psoriasis to determine the mechanisms underlying the therapeutic efficacy of <jats:italic>S.\u00a0chamaejasme<\/jats:italic>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>Compounds isolated by column chromatography were structurally identified using NMR spectroscopy. The effects of SA on IL\u201017A\u2010treated HaCaT cell viability and apoptosis were assessed using CCK\u20108 and TUNEL assays. In vivo anti\u2010psoriasis activity of SA was evaluated in a mouse model of imiquimod (IMQ)\u2010induced psoriasis. Network pharmacology, surface plasmon resonance (SPR), drug affinity responsive target stability (DARTS), and cellular thermal shift assays (CETSA) were elucidated the interactions between SA and the targets.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>SA was isolated from <jats:italic>S.\u00a0chamaejasme<\/jats:italic> along with nine known analogues (<jats:bold>2<\/jats:bold>\u2013<jats:bold>10<\/jats:bold>). In vivo, SA reduced IMQ\u2010induced epidermal thickness, hyperkeratosis, and perivascular inflammatory cell infiltration. Network pharmacology indicated that SA may function via the interleukin IL\u201017A\/STAT1\/S100A9 pathway. The results of SPR assays and molecular docking showed that SA binds to STAT1 with a <jats:italic>K<\/jats:italic><jats:sub>D<\/jats:sub> value of 9.24\u2009nM. DARTS and CETSA analyses confirmed a direct and relevant interaction between SA and STAT1.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion and Implications<\/jats:title><jats:p>SA modulates the immunological microenvironment to treat psoriasis by targeting the IL\u201017A\/STAT1\/S100A9 axis, representing a potential new treatment for psoriasis and other IL\u201017A\u2010mediated skin disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.70059","type":"journal-article","created":{"date-parts":[[2025,4,28]],"date-time":"2025-04-28T23:19:55Z","timestamp":1745882395000},"page":"3884-3902","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Macrocyclic diterpenoids from <i>Stellera chamaejasme<\/i> roots alleviate imiquimod\u2010induced psoriasiform inflammation via STAT1\/S100A9 signalling pathway"],"prefix":"10.1111","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6478-4770","authenticated-orcid":false,"given":"Yi\u2010Wen","family":"Nie","sequence":"first","affiliation":[{"name":"Department of Pharmacy Research, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-8432-8179","authenticated-orcid":false,"given":"Xin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ying","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Research, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5410-1048","authenticated-orcid":false,"given":"Chun\u2010Yan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Seventh People\u2019s Hospital of Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruo\u2010Fan","family":"Xi","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiao\u2010Xue","family":"Jiang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science &amp; Yunnan Key Laboratory of Pharmacology for Natural Products Kunming Medical University  Kunming Yunnan China"},{"name":"College of Modern Biomedical Industry Kunming Medical University  Kunming Yunnan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Zhi","family":"Lu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dong\u2010Jie","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wan\u2010Jun","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1995-8449","authenticated-orcid":false,"given":"Yan\u2010Juan","family":"Duan","sequence":"additional","affiliation":[{"name":"Seventh People\u2019s Hospital of Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Nian","sequence":"additional","affiliation":[{"name":"Department of Pharmacy Research, Yueyang Hospital of Integrated Traditional Chinese and Western Medicine Shanghai University of Traditional Chinese Medicine  Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3469-2789","authenticated-orcid":false,"given":"Kou","family":"Wang","sequence":"additional","affiliation":[{"name":"School of Pharmaceutical Science &amp; 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