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The central nervous system (CNS) helps regulate immune responses through neuroendocrine pathways, such as the hypothalamic\u2013pituitary\u2013adrenal axis and the anti\u2010inflammatory reflex, which limit systemic inflammation. Immune responses require significant metabolic energy and the liver adapts by increasing glucose production and mobilizing fatty acids. This immune\u2010metabolic coordination is mediated by cytokines and metabolic regulators. This review explores how the anti\u2010inflammatory reflex modulates the interplay between inflammation and metabolism during endotoxaemia, with a focus on the haem oxygenase 1\/carbon monoxide (HO1\/CO) pathway. Carbon monoxide, a byproduct of HO1 activity, acts as a key signalling molecule that reduces inflammation, supports mitochondrial function and protects tissues. 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