{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T15:38:17Z","timestamp":1784734697719,"version":"3.55.0"},"reference-count":57,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T00:00:00Z","timestamp":1754697600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Post\u2010traumatic stress disorder (PTSD) is a significant challenge in the military population and civilians exposed to danger and violence. Alcohol use disorder (AUD) and pain are common PTSD comorbidities, with a higher incidence in PTSD patients than the general population. Approved pharmacotherapies for these disorders are often ineffective and adverse effect potential limits use. No current drugs address both PTSD and alcohol use disorder. This study examines whether the opioid partial agonist PPL\u2010138 (BU10038) alleviates preclinical behaviours associated with PTSD such as anxiety, pain and comorbid alcohol use.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>The single prolonged stress (SPS) model induced PTSD\u2010like phenotypes in male and female Sprague\u2013Dawley rats. As PTSD afflicts only a subset of humans exposed to trauma, the effect of PPL\u2010138 on alcohol self\u2010administration was tested in SPS susceptible and resilient rat populations (defined by anxiety phenotype and escalation of alcohol\u2010related responses).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>PPL\u2010138 effectively reduces anxiety\u2010like behaviour, tactile allodynia and thermal hyperalgesia induced by SPS. It also decreases escalated alcohol consumption in male rats exhibiting comorbid anxiety\u2010like behaviour, leaving alcohol intake unaltered in non\u2010anxious phenotypes or in rats not exposed to traumatic\u2010like stress. The compound has a similar effect in female rats, as it reduces alcohol self\u2010administration selectively in anxious female rats.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications<\/jats:title>\n                    <jats:p>Results support the efficacy of PPL\u2010138 to attenuate behavioural traits attributable to PTSD and alcohol consumption associated with elevated anxiety in an AUD\u2013PTSD population.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70151","type":"journal-article","created":{"date-parts":[[2025,8,9]],"date-time":"2025-08-09T11:29:51Z","timestamp":1754738991000},"page":"5883-5898","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["The opioid partial agonist PPL\u2010138 reduces alcohol self\u2010administration in rats susceptible to post\u2010traumatic stress disorder"],"prefix":"10.1111","volume":"182","author":[{"given":"Andrea","family":"Cippitelli","sequence":"first","affiliation":[{"name":"Department of Biomedical Science, Charles E. 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