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However, its efficacy and molecular mechanism in MASH have not been elucidated.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>\n                      Two diet\u2010induced MASH models were used to evaluate the therapeutic potential of ELE\n                      <jats:italic>in vivo<\/jats:italic>\n                      . Additionally, RNA sequencing, network pharmacological analysis, and target validation were performed to elucidate the underlying mechanisms.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>ELE markedly ameliorated lipid dysfunction and the inflammatory response in MASH mice and fatty acids\u2010stimulated hepatocytes. RNA\u2010sequencing analysis indicated that ELE exerted its therapeutic effects through activating the PPAR\u03b1 signalling pathway. Particularly, we found that ELE directly binds to PPAR\u03b1 protein, preventing its degradation via K48\u2010linked polyubiquitination. Notably, the protective effects of ELE on MASH were abolished in the absence of PPAR\u03b1.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Implications<\/jats:title>\n                    <jats:p>Our studies reveal that ELE is a novel stabiliser of PPAR\u03b1, effectively inhibiting its ubiquitin\u2010mediated degradation in MASH. By preserving the PPAR\u03b1 signalling pathway, ELE enhances lipid homeostasis and relieves the inflammation. Therefore, ELE holds significant potential as a therapeutic candidate for the treatment of MASH.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70161","type":"journal-article","created":{"date-parts":[[2025,8,8]],"date-time":"2025-08-08T04:24:56Z","timestamp":1754627096000},"page":"5847-5864","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["\u03b2\u2010elemene ameliorates metabolic dysfunction\u2010associated steatohepatitis by targeting PPAR\u03b1 in experimental diet\u2010induced models"],"prefix":"10.1111","volume":"182","author":[{"given":"Yongqiang","family":"Xiong","sequence":"first","affiliation":[{"name":"Department of Cardiology the First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"},{"name":"Department of Endocrinology and Medical Research Center the First Affiliated Hospital of Wenzhou Medical University  Wenzhou Zhejiang China"},{"name":"Chemical Biology 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