{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,9]],"date-time":"2026-03-09T04:55:58Z","timestamp":1773032158894,"version":"3.50.1"},"reference-count":48,"publisher":"Wiley","issue":"23","license":[{"start":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T00:00:00Z","timestamp":1754179200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,3]],"date-time":"2025-08-03T00:00:00Z","timestamp":1754179200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["NRF\u20102023R1A2C1007463"],"award-info":[{"award-number":["NRF\u20102023R1A2C1007463"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Statins are widely prescribed for the prevention of cardiovascular disease, yet recent studies suggest an increased risk of new\u2010onset Type 2 diabetes mellitus. This study aimed to identify genetic variants associated with statin\u2010associated new\u2010onset Type 2 diabetes mellitus from the UK Biobank and All of Us.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>Among statin users, cases were defined as those diagnosed with Type 2 diabetes mellitus after statin initiation and controls as those never having diabetes mellitus. A genome\u2010wide association study (GWAS) was performed using logistic regression analysis with an additive model using the UK Biobank. We conducted a replication analysis in the All of Us cohort using the lead variants identified in the UK Biobank. Additionally, we tested interaction analyses between statin use and lead variants.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      The GWAS identified four significant lead variants. The most significant,\n                      <jats:italic>TCF7L2<\/jats:italic>\n                      rs7903146, increased risk of new\u2010onset Type 2 diabetes mellitus by 1.3\u2010fold. Similarly,\n                      <jats:italic>POU5F1<\/jats:italic>\n                      rs879882 was associated with a higher risk. By contrast,\n                      <jats:italic>CCND2<\/jats:italic>\n                      rs76895963 and\n                      <jats:italic>ADCY5<\/jats:italic>\n                      rs35841686 were associated with a lower risk. In the replication analysis of the All of Us cohort,\n                      <jats:italic>TCF7L2<\/jats:italic>\n                      rs7903146,\n                      <jats:italic>CCND2<\/jats:italic>\n                      rs76895963 and\n                      <jats:italic>POU5F1<\/jats:italic>\n                      rs879882 remained significant. In the interaction analyses, those three lead variants also exhibited additive interactions with statin use.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Implications<\/jats:title>\n                    <jats:p>These findings provide insights that may support personalized statin therapy to mitigate diabetic risk.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70164","type":"journal-article","created":{"date-parts":[[2025,8,4]],"date-time":"2025-08-04T04:34:11Z","timestamp":1754282051000},"page":"5803-5813","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Genetic variants linked to statin\u2010associated Type 2 diabetes mellitus: Findings from the UK Biobank and the All of Us Research 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