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Adolescent <jats:italic>Cannabis<\/jats:italic> use has increased, which can impair cognitive function during this critical developmental stage. The persistence of such effects into adulthood, however, is unclear. The present study examined whether chronic \u0394<jats:sup>9<\/jats:sup>\u2010tetrahydrocannabinol (\u0394<jats:sup>9<\/jats:sup>\u2010THC) exposure during adolescence modifies subsequent \u0394<jats:sup>9<\/jats:sup>\u2010THC\u2010induced cognitive deficits during adulthood.<\/jats:p><\/jats:sec><jats:sec><jats:title>Experimental Approach<\/jats:title><jats:p>Female and male adolescent nonhuman primates were treated intramuscular daily for 6\u2009months with either vehicle, a low dose of \u0394<jats:sup>9<\/jats:sup>\u2010THC (0.32\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>\u00a0day<jats:sup>\u22121<\/jats:sup>), or a high dose (3.2\u2009mg\u2009kg<jats:sup>\u22121<\/jats:sup>\u00a0day<jats:sup>\u22121<\/jats:sup>). Approximately 1\u2009year after discontinuing chronic exposure, these subjects, now adults, were trained on a touchscreen\u2010based Psychomotor Vigilance Task (PVT) to examine attentional processes. Acute doses of \u0394<jats:sup>9<\/jats:sup>\u2010THC were administered prior to select test sessions via two routes, intramuscular or oral, to evaluate the roles of adolescent drug history and method of consumption on \u0394<jats:sup>9<\/jats:sup>\u2010THC\u2010induced attentional deficits.<\/jats:p><\/jats:sec><jats:sec><jats:title>Key Results<\/jats:title><jats:p>Results confirm dose\u2010related \u0394<jats:sup>9<\/jats:sup>\u2010THC impairment of PVT performance by both intramuscular and oral routes of administration, notwithstanding differences in potency and onset of action. Adolescent drug history modified tolerance to \u0394<jats:sup>9<\/jats:sup>\u2010THC impact on attentional processes, where subjects exposed to chronic \u0394<jats:sup>9<\/jats:sup>\u2010THC during adolescence required higher doses of \u0394<jats:sup>9<\/jats:sup>\u2010THC during adulthood to impair PVT performance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions and Implications<\/jats:title><jats:p>These findings suggest a persistent impact of adolescent \u0394<jats:sup>9<\/jats:sup>\u2010THC use that, even following extended abstinence, may present itself during adulthood via increased tolerance to <jats:italic>Cannabis<\/jats:italic> products.<\/jats:p><\/jats:sec>","DOI":"10.1111\/bph.70179","type":"journal-article","created":{"date-parts":[[2025,8,22]],"date-time":"2025-08-22T07:15:17Z","timestamp":1755846917000},"page":"5149-5156","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Chronic \u0394<sup>9<\/sup>\u2010tetrahydrocannabinol exposure during adolescence is associated with persistent behavioural tolerance in adult nonhuman primates"],"prefix":"10.1111","volume":"182","author":[{"given":"Yasaman","family":"Razavi","sequence":"first","affiliation":[{"name":"Harvard Medical School McLean Hospital  Belmont Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Kohut","sequence":"additional","affiliation":[{"name":"Harvard Medical School McLean Hospital  Belmont Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jack","family":"Bergman","sequence":"additional","affiliation":[{"name":"Harvard Medical School McLean Hospital  Belmont Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4597-9801","authenticated-orcid":false,"given":"Brian D.","family":"Kangas","sequence":"additional","affiliation":[{"name":"Harvard Medical School McLean Hospital  Belmont Massachusetts USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,22]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-019-5171-1"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15537"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000155258"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4757-0812-7_2"},{"volume-title":"Beyond sociobiology","year":"1981","author":"Baldwin J. 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