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This pathology is a major burden of cardiovascular disease. The etiopathogenesis and clinical manifestation of ACS are predominantly attributable to myocardial hypoperfusion consequent, to coronary vessel occlusion, typically resulting from atherosclerotic plaque rupture and subsequent thrombosis. Dual antiplatelet therapy (DAPT), comprising aspirin and a P2Y\n                    <jats:sub>12<\/jats:sub>\n                    receptor antagonist, has long been the mainstay of ACS management. Notwithstanding, limitations in the pharmacokinetic (PK) and pharmacodynamic (PD) profiles of conventional DAPT agents persist. Selatogrel (ACT\u2010246475), a novel P2Y\n                    <jats:sub>12<\/jats:sub>\n                    antagonist currently undergoing Phase III clinical trial, is poised to revolutionise ACS treatment. This highly selective and potent 2\u2010phenylpyrimidine\u20104\u2010carboxamide analogue is administered subcutaneously. 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Subsequent investigations will serve to support or refine its therapeutic attributes.\n                  <\/jats:p>","DOI":"10.1111\/bph.70203","type":"journal-article","created":{"date-parts":[[2025,9,20]],"date-time":"2025-09-20T03:57:47Z","timestamp":1758340667000},"page":"5435-5452","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Selatogrel: Potential to redefine timely anti\u2010platelet intervention"],"prefix":"10.1111","volume":"182","author":[{"given":"Rudy N.","family":"Zalzal","sequence":"first","affiliation":[{"name":"Faculty of Medicine American University of Beirut  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter P.","family":"Salem","sequence":"additional","affiliation":[{"name":"Faculty of Medicine American University of Beirut  Beirut Lebanon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali H.","family":"Dakroub","sequence":"additional","affiliation":[{"name":"The Zena and Michael A. 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