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The concise nature of the Concise Guide refers to the style of presentation, being clear, accessible, and well\u2010structured, rather than the scope of the content, which spans approximately 500 pages. The Concise Guide summarises the key pharmacological properties of around 1900 human drug targets, and nearly 7000 interactions, involving around 4400 ligands. While the content is a substantially condensed version of the more detailed information and links available at the\n www.guidetopharmacology.org<\/jats:ext-link>\n website, the printed guide serves as a permanent, citable, point\u2010in\u2010time record, that remains stable despite ongoing updates to the online database. The full contents of this publication can be found at\n https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.70230<\/jats:ext-link>\n .\n <\/jats:p>\n The Concise Guides provide expert\u2010curated recommendations of \u2018Gold Standard\u2019 selective pharmacological tools, available either commercially or as donations, which enable the identification of individual drug targets or families of drug targets. While the Concise Guide offers a more streamlined overview, more comprehensive information, including detailed pharmacological profiles and links to multiple online databases, is available through the Guide to Pharmacology website. The 2025\/26 edition of the Concise Guide is based on material current as of mid\u20102025, and supersedes all previous editions, including the 2023\/24 Guide, and earlier Guides to Receptors and Channels. 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Each section includes nomenclature guidance, concise summaries, information of the best available pharmacological tools, key references, and suggestions for further reading.<\/jats:p>","DOI":"10.1111\/bph.70230","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T02:30:36Z","timestamp":1767061836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":100,"title":["The Concise Guide to PHARMACOLOGY 2025\/26: G protein\u2010coupled receptors"],"prefix":"10.1111","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4417-497X","authenticated-orcid":false,"given":"Stephen P. 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