{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T14:53:17Z","timestamp":1791989597945,"version":"4.4.0"},"reference-count":0,"publisher":"Wiley","issue":"S1","license":[{"start":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T00:00:00Z","timestamp":1766966400000},"content-version":"vor","delay-in-days":28,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2025,12]]},"abstract":"\n The Concise Guide to Pharmacology 2025\/26 marks the seventh edition in this series of biennial publications in the British Journal of Pharmacology. Presented in landscape format, the guide provides a comparative overview of the pharmacology of drug target families. The concise nature of the Concise Guide refers to the style of presentation, being clear, accessible, and well\u2010structured, rather than the scope of the content, which spans approximately 500 pages. The Concise Guide summarises the key pharmacological properties of around 1900 human drug targets, and nearly 7000 interactions, involving around 4400 ligands. While the content is a substantially condensed version of the more detailed information and links available at the\n www.guidetopharmacology.org<\/jats:ext-link>\n website, the printed guide serves as a permanent, citable, point\u2010in\u2010time record, that remains stable despite ongoing updates to the online database. The full contents of this publication can be found at\n https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.70232<\/jats:ext-link>\n .\n <\/jats:p>\n The Concise Guides provide expert\u2010curated recommendations of \u2018Gold Standard\u2019 selective pharmacological tools, available either commercially or as donations, which enable the identification of individual drug targets or families of drug targets. While the Concise Guide offers a more streamlined overview, more comprehensive information, including detailed pharmacological profiles and links to multiple online databases, is available through the Guide to Pharmacology website. The 2025\/26 edition of the Concise Guide is based on material current as of mid\u20102025, and supersedes all previous editions, including the 2023\/24 Guide, and earlier Guides to Receptors and Channels. It is produced in close conjunction with the Nomenclature and Standards Committee of the International Union of Basic and Clinical Pharmacology (NC\u2010IUPHAR), and as such provides official IUPHAR classification and nomenclature for human drug targets, where applicable.<\/jats:p>\n Nuclear hormone receptors are one of the six major pharmacological targets into which the Guide is divided, with the others being: G protein\u2010coupled receptors, ion channels, catalytic receptors, enzymes and transporters. Each section includes nomenclature guidance, concise summaries information of the best available pharmacological tools, key references, and suggestions for further reading.<\/jats:p>","DOI":"10.1111\/bph.70232","type":"journal-article","created":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T02:30:36Z","timestamp":1767061836000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["The Concise Guide to PHARMACOLOGY 2025\/26: Nuclear hormone receptors"],"prefix":"10.1111","volume":"182","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4417-497X","authenticated-orcid":false,"given":"Stephen P. H.","family":"Alexander","sequence":"first","affiliation":[{"name":"Division of Physiology, Pharmacology & Neuroscience, School of Life Sciences University of Nottingham Medical School Nottingham NG7 2UH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1420-0516","authenticated-orcid":false,"given":"John A.","family":"Cidlowski","sequence":"additional","affiliation":[{"name":"National Institute of Environmental Health Sciences National Institutes of Health, Department of Health and Human Services, Research Triangle Park NC 27709 USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2145-1615","authenticated-orcid":false,"given":"Alasdair J.","family":"Gibb","sequence":"additional","affiliation":[{"name":"Research Department of Neuroscience, Physiology and Pharmacology, Division of Biosciences University College London Gower Street London WC1E 6BT UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9183-3993","authenticated-orcid":false,"given":"Eamonn","family":"Kelly","sequence":"additional","affiliation":[{"name":"School of Psychology and Neuroscience University of Bristol Bristol BS8 1TD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6094-2890","authenticated-orcid":false,"given":"Alistair A.","family":"Mathie","sequence":"additional","affiliation":[{"name":"School of Life Sciences University of Westminster London W1W 6UW UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6315-1170","authenticated-orcid":false,"given":"Chloe J.","family":"Peach","sequence":"additional","affiliation":[{"name":"Division of Physiology, Pharmacology & Neuroscience, School of Life Sciences, Centre of Membrane Proteins and Receptors (COMPARE) University of Nottingham Medical School Nottingham NG7 2UH UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6778-9929","authenticated-orcid":false,"given":"Emma L.","family":"Veale","sequence":"additional","affiliation":[{"name":"Medway School of Pharmacy Universities of Kent and Greenwich, Chatham Maritime Kent ME4 4TB UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0524-0260","authenticated-orcid":false,"given":"Jane F.","family":"Armstrong","sequence":"additional","affiliation":[{"name":"Institute for Neuroscience and Cardiovascular Research University of Edinburgh Edinburgh EH8 9XD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9855-7103","authenticated-orcid":false,"given":"Elena","family":"Faccenda","sequence":"additional","affiliation":[{"name":"Institute for Neuroscience and Cardiovascular Research University of Edinburgh Edinburgh EH8 9XD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9262-8318","authenticated-orcid":false,"given":"Simon D.","family":"Harding","sequence":"additional","affiliation":[{"name":"Institute for Neuroscience and Cardiovascular Research University of Edinburgh Edinburgh EH8 9XD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9580-0446","authenticated-orcid":false,"given":"Christopher","family":"Southan","sequence":"additional","affiliation":[{"name":"Institute for Neuroscience and Cardiovascular Research University of Edinburgh Edinburgh EH8 9XD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6660-4032","authenticated-orcid":false,"given":"Jamie A.","family":"Davies","sequence":"additional","affiliation":[{"name":"Institute for Neuroscience and Cardiovascular Research University of Edinburgh Edinburgh EH8 9XD UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laurel","family":"Coons","sequence":"additional","affiliation":[{"name":"Duke University Medical Center Durham USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter J.","family":"Fuller","sequence":"additional","affiliation":[{"name":"Hudson Institute of Medical Research Clayton Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenneth S.","family":"Korach","sequence":"additional","affiliation":[{"name":"National Institutes of Health, Research Triangle Park USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald P.","family":"McDonell","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine Durham USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"Oakley","sequence":"additional","affiliation":[{"name":"National Institutes of Health, Research Triangle Park USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-5877-7033","authenticated-orcid":false,"given":"Sarah","family":"Radi","sequence":"additional","affiliation":[{"name":"University of California Riverside Riverside USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rachid","family":"Safi","sequence":"additional","affiliation":[{"name":"Duke University School of Medicine Durham USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8346-8474","authenticated-orcid":false,"given":"Frances","family":"Sladek","sequence":"additional","affiliation":[{"name":"University of California Riverside Riverside USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morag J.","family":"Young","sequence":"additional","affiliation":[{"name":"Monash University Melbourne Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,29]]},"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70232","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,30]],"date-time":"2025-12-30T02:30:40Z","timestamp":1767061840000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.70232"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12]]},"references-count":0,"journal-issue":{"issue":"S1","published-print":{"date-parts":[[2025,12]]}},"alternative-id":["10.1111\/bph.70232"],"URL":"https:\/\/doi.org\/10.1111\/bph.70232","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12]]},"assertion":[{"value":"2025-12-29","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}