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We aimed to investigate whether IP6 could protect cochlear hair cells and ameliorate sensorineural hearing loss (SNHL) in multiple experimental mouse models of SNHL.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>\n                      Three SNHL female mouse models were designed, namely (1) a model induced by the chemotherapy drug cisplatin (3\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      , intraperitoneal [i.p.] injection), (2) a model induced by aminoglycosides (kanamycin, 1\u2009g\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      , subcutaneous injection; furosemide 0.1\u2009g\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      , i.p. injection), and (3) an age\u2010related hearing loss (ARHL) mouse model. For IP6 treatments, IP6 (40 or 80\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) was injected i.p. into multiple mouse models to investigate its protective effects on SNHL and ARHL. In addition, another group of mice was fed 2% IP6 (added in their drinking water) to investigate its protective effects on ARHL.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      The collected ABR data suggested that IP6 (80\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) significantly reduced hearing threshold shifts in all three female mouse models. Furthermore, the collected immunohistochemical staining data suggested that IP6 significantly ameliorated the loss of outer hair cells in all three mouse models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Implications<\/jats:title>\n                    <jats:p>These findings support further investigation of IP6 as a potential otoprotective agent for future clinical translation.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70237","type":"journal-article","created":{"date-parts":[[2025,11,22]],"date-time":"2025-11-22T02:36:06Z","timestamp":1763778966000},"page":"1486-1501","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Inositol hexaphosphate alleviates ototoxicity and age\u2010related hearing loss by preserving cochlear hair cells in mice"],"prefix":"10.1111","volume":"183","author":[{"given":"Stella Chin\u2010Shaw","family":"Tsai","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Tungs' Taichung MetroHarbor Hospital  Taichung City Taiwan"},{"name":"Rong Hsing Research Center for Translational Medicine, College of Life Sciences National Chung Hsing University  Taichung City Taiwan"},{"name":"Department Post\u2010Baccalaureate Medicine, College of Medicine National Chung Hsing University  Taichung City Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chang\u2010Yin","family":"Lee","sequence":"additional","affiliation":[{"name":"College of Medicine, The School of Chinese Medicine for Post Baccalaureate I\u2010Shou University  Kaohsiung Taiwan"},{"name":"Department of Chinese Medicine E\u2010DA Hospital  Kaohsiung Taiwan"},{"name":"Department of Chinese Medicine E\u2010DA Cancer Hospital  Kaohsiung 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