{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:26:38Z","timestamp":1780478798635,"version":"3.54.1"},"reference-count":51,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,8]],"date-time":"2025-12-08T00:00:00Z","timestamp":1765152000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004281","name":"Narodowe Centrum Nauki","doi-asserted-by":"publisher","award":["2020\/04\/X\/NZ7\/00065"],"award-info":[{"award-number":["2020\/04\/X\/NZ7\/00065"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>\n                      Recognition and procedural memory are modulated by the noradrenergic system, whose terminals release noradrenaline along with neuropeptide Y, acting via Y1 and Y2 receptors. This study aims to investigate the role of Y1 and Y2 receptor antagonists (BMS\u2010193885 and SF\u201011) on recognition and procedural memory, including their co\u2010administration with clenbuterol, a \u03b2\n                      <jats:sub>2<\/jats:sub>\n                      \u2010adrenoceptor agonist, with additional focus on the molecular mechanisms underlying memory\u2010related behavioural changes.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>Recognition memory was assessed in mice using the novel object recognition task. Motor learning and procedural memory were evaluated in the accelerating rotarod test. Memory\u2010related behavioural outcomes were complemented by analyses of NPY levels, the phosphorylation status of CaMKII and ERK1\/2, along with the concentrations of 5\u2010HT, dopamine, noradrenaline and its metabolite in selected brain regions, including the prefrontal cortex, hippocampus and cerebellum.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      SF\u201011 at 5\u00a0mg\u00b7kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      impaired recognition memory, prolonged procedural memory retention and inhibited CaMKII, but at 20\u2009mg\u00b7kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      , SF\u201011 disrupted both recognition and procedural memory increasing NPY. BMS\u2010193885, at 5\u2009mg\u00b7kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      , prolonged procedural memory retention, but at 20\u2009mg\u00b7kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      , it impaired long\u2010term recognition memory, prolonged procedural memory retention, increased NPY and decreased phospho\u2010CaMKII. Clenbuterol enhanced procedural memory retention, but this pro\u2010cognitive effect was diminished by co\u2010administration with either Y receptor antagonist, which correlated with decreased noradrenaline levels.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications<\/jats:title>\n                    <jats:p>NPY receptor antagonists modulate memory processes in a dose\u2010 and memory\u2010type\u2010dependent manner, and these effects appear to be linked to hippocampal function. NPY receptors may serve as therapeutic targets to treat cognitive impairments.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70287","type":"journal-article","created":{"date-parts":[[2025,12,9]],"date-time":"2025-12-09T01:01:16Z","timestamp":1765242076000},"page":"1958-1974","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["NPY Y\n                    <sub>1<\/sub>\n                    and Y\n                    <sub>2<\/sub>\n                    receptors in the regulation of mouse recognition and procedural memory: Interplay with cellular signalling, noradrenergic transmission and monoamine concentrations"],"prefix":"10.1111","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8425-7713","authenticated-orcid":false,"given":"Agnieszka","family":"Michalak","sequence":"first","affiliation":[{"name":"Independent Laboratory of Behavioral Studies Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1005-8068","authenticated-orcid":false,"given":"\u0141ukasz","family":"Kurach","sequence":"additional","affiliation":[{"name":"Independent Laboratory of Behavioral Studies Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2258-4225","authenticated-orcid":false,"given":"Artur","family":"Wnorowski","sequence":"additional","affiliation":[{"name":"Department of Biopharmacy Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3663-7851","authenticated-orcid":false,"given":"Anita","family":"Kowal","sequence":"additional","affiliation":[{"name":"Independent Laboratory of Behavioral Studies Medical University of Lublin  Lublin Poland"},{"name":"Center for Microbiology and Immunology, Lewis Katz School of Medicine Temple University  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7040-4754","authenticated-orcid":false,"given":"Dominika","family":"Przygodzka","sequence":"additional","affiliation":[{"name":"Laboratory of Forensic Toxicology Medical University of Lublin  Lublin Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0050-6047","authenticated-orcid":false,"given":"Vardan T.","family":"Karamyan","sequence":"additional","affiliation":[{"name":"Department of Foundational Medical Studies, Laboratory for Neurodegenerative Disease and Drug Discovery Oakland University William Beaumont School of Medicine  Rochester Minnesota USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,12,8]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11095-019-2745-x"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16177"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16181"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14112"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-012-0310-7"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/NDT.S67184"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.06.032"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108425"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1124\/mol.109.058677"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1320827111"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2020.135008"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.17441"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2011.06.018"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2023.114729"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.9b00082"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2021.650614"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2010.07.052"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.028449.112"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2007.09.010"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0163-1047(86)90710-7"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245663"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1051\/bioconf\/20110100047"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3343-09.2009"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.reach.2019.100032"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2010-0521"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-07273-x"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108199"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharep.2014.02.002"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15178"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.3791\/55718"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2010.02242.x"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2014.08.016"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2020.108302"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2022.05.015"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.3233\/JPD-213081"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurobiolaging.2007.02.003"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.peptides.2012.01.004"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2013.07.012"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.22143"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1155\/2020\/8324565"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.2019"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-023-01679-y"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(01)00583-6"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00560.x"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.146"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2010.07154.x"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2021.667244"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2018.01.011"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1037\/\/0735-7044.114.6.1131"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchromb.2011.02.011"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70287","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.70287","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70287","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T03:16:53Z","timestamp":1775791013000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.70287"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,12,8]]},"references-count":51,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/bph.70287"],"URL":"https:\/\/doi.org\/10.1111\/bph.70287","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,12,8]]},"assertion":[{"value":"2025-07-18","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-10-29","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-08","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}