{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T21:27:13Z","timestamp":1781731633611,"version":"3.54.5"},"reference-count":50,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2025,12,17]],"date-time":"2025-12-17T00:00:00Z","timestamp":1765929600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["CA148706"],"award-info":[{"award-number":["CA148706"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>The clinical success of small\u2010molecule drugs in treating pancreatic and prostate cancer patients has been both promising and challenging. Whereas patients with advanced\u2010stage tumours have significant initial responses to chemotherapy, many have experienced rapid resistance, metastasis and recurrence after curative\u2010intent surgery. Traditional tubulin inhibitors are widely used in cancer treatment, but their effectiveness is often limited by drug resistance and toxicity. SB\u2010216, a novel colchicine\u2010binding site inhibitor (CBSI), has been reported to demonstrate potential efficacy in overcoming paclitaxel (PTX) resistance in a melanoma xenograft model (A375\/TxR) and inhibiting spontaneous metastasis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>We evaluated SB\u2010216 as a therapeutic option for advanced malignancies, specifically castration\u2010resistant prostate cancer (CRPC) and pancreatic ductal adenocarcinoma (PDAC). We conducted preclinical evaluations of SB\u2010216 in CRPC parental and taxane\u2010resistant lines. Additionally, we investigated the effects of SB\u2010216 on PDAC cells, xenograft models and patient\u2010derived models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      In vitro, SB\u2010216 potently induces G2\/M phase cell cycle arrest, inhibits cell proliferation, colony formation and cell migration in a concentration\u2010dependent manner. In vivo, SB\u2010216 significantly attenuates tumour growth in prostate cancer xenograft models, overcomes PTX resistance and confers a survival benefit at a dose of 2\u2009mg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      without affecting body weight. SB\u2010216 also inhibits the growth of PDAC xenograft tumours and the growth of patient\u2010derived cells and organoids.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications<\/jats:title>\n                    <jats:p>Our findings suggest that SB\u2010216 is a promising candidate as a new generation of anti\u2010mitotic agents for advanced cancer, and further exploration in combination with other agents is warranted.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70294","type":"journal-article","created":{"date-parts":[[2025,12,18]],"date-time":"2025-12-18T05:16:21Z","timestamp":1766034981000},"page":"2080-2098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Anti\u2010mitotic agent SB\u2010216 overcomes taxane resistance in castration\u2010resistant prostate cancer and exhibits anti\u2010tumour efficacy in pancreatic cancer"],"prefix":"10.1111","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9348-1058","authenticated-orcid":false,"given":"Rui","family":"Wang","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Sciences, College of Pharmacy University of Tennessee Health Science Center  Memphis Tennessee USA"},{"name":"College of Graduate Health Sciences University of Tennessee Health Science Center  Memphis Tennessee USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-3827-6221","authenticated-orcid":false,"given":"Chun","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Surgery, College of Medicine University of Tennessee Health Science Center  Memphis Tennessee USA"},{"name":"Center for Cancer Research University of Tennessee Health Science Center  Memphis TN 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