{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,9]],"date-time":"2026-05-09T18:26:54Z","timestamp":1778351214543,"version":"3.51.4"},"reference-count":57,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,1,15]],"date-time":"2026-01-15T00:00:00Z","timestamp":1768435200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01 BX004024"],"award-info":[{"award-number":["I01 BX004024"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["IK6 RD001204"],"award-info":[{"award-number":["IK6 RD001204"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["I01"],"award-info":[{"award-number":["I01"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["BX004024"],"award-info":[{"award-number":["BX004024"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["IK6"],"award-info":[{"award-number":["IK6"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","award":["RD001204"],"award-info":[{"award-number":["RD001204"]}],"id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL144788"],"award-info":[{"award-number":["HL144788"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["AT006704"],"award-info":[{"award-number":["AT006704"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL132989"],"award-info":[{"award-number":["HL132989"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000738","name":"U.S. Department of Veterans Affairs","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000738","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>The leukocyte\u2010mediated innate inflammatory response is crucial for clearing ischaemic debris during myocardial infarction (MI). If unresolved, it leads to chronic inflammation and heart failure. While macrophages produce specialised pro\u2010resolving mediators (SPMs) like maresin 1, the therapeutic potential of exogenous maresin 1 in cardiac repair remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>\n                      Male C57BL\/6J mice (8\u201312\u2009weeks) subjected coronary artery ligation to induce MI. Mice received either low\u2010dose (LD; 0.4\u2009\u03bcg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) or high\u2010dose (HD; 4\u2009\u03bcg\u2009kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ) maresin 1 subcutaneously 3\u2009h post\u2010MI, continued through day 1 or day 5. Saline\u2010injected mice served as MI controls, while non\u2010infarcted mice were used as na\u00efve controls.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      LD\u2010maresin 1 enhanced neutrophil clearance but did not improve cardiac function. However, HD\u2010maresin 1 significantly improved cardiac performance, evidenced by higher fractional shortening and global longitudinal strain, and reducing LV and lung mass\u2010to\u2010body weight ratios. In infarcted myocardium, HD\u2010maresin 1 up\u2010regulated FPR2 receptor expression and increased levels of SPMs (RvD5, PD\u20101, maresin 1). Flow cytometry showed accelerated neutrophil clearance from the LV and spleen. Moreover, HD\u2010maresin 1 also promoted a reparative macrophage phenotype, with expansion of Ly6C\n                      <jats:sup>lo<\/jats:sup>\n                      cells and up\u2010regulation of\n                      <jats:italic>Mrc1<\/jats:italic>\n                      and\n                      <jats:italic>Arg1<\/jats:italic>\n                      . Furthermore, kidney immunohistochemistry showed reduced NGAL and increased nephrin expression, indicating attenuation of cardiorenal inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications<\/jats:title>\n                    <jats:p>High\u2010dose maresin 1 activates FPR2 signalling and enhances the resolution of inflammation by modulating leukocyte dynamics and macrophage phenotype. Improving cardiac function and attenuating cardiorenal inflammation, highlighting the therapeutic potential of maresin 1 in cardiac healing and acute heart failure.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70318","type":"journal-article","created":{"date-parts":[[2026,1,16]],"date-time":"2026-01-16T06:50:35Z","timestamp":1768546235000},"page":"2429-2445","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Maresin 1 promotes resolution of inflammation and improves left ventricle function in acute heart failure"],"prefix":"10.1111","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5351-9354","authenticated-orcid":false,"given":"Ganesh V.","family":"Halade","sequence":"first","affiliation":[{"name":"Heart Institute, Division of Cardiovascular Sciences, Department of Internal Medicine, Morsani College of Medicine University of South Florida  Tampa Florida USA"},{"name":"Hypertension and Kidney Research Center University of South Florida  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kevin A.","family":"Ingle","sequence":"additional","affiliation":[{"name":"Division of Cardiovascular Disease, Department of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romain A.","family":"Travis","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Alabama at Birmingham  Birmingham Alabama USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shahriare","family":"Hossain","sequence":"additional","affiliation":[{"name":"Heart Institute, Division of Cardiovascular Sciences, Department of Internal Medicine, Morsani College of Medicine University of South Florida  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Staruschenko","sequence":"additional","affiliation":[{"name":"Hypertension and Kidney Research Center University of South Florida  Tampa Florida USA"},{"name":"Department of Molecular Pharmacology and Physiology University of South Florida  Tampa Florida USA"},{"name":"James A. Haley Veterans' Hospital  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasundhara","family":"Kain","sequence":"additional","affiliation":[{"name":"Heart Institute, Division of Cardiovascular Sciences, Department of Internal Medicine, Morsani College of Medicine University of South Florida  Tampa Florida USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,1,15]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16177"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16182"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16181"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14112"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00169.2025"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2014.02.009"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V80.8.2012.2012"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.17441"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1203000"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.01400"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2025.177456"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.0903526"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2014.28"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.23-04-01228.2003"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00267.2025"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.12659\/msm.915108"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00528.2017"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201701173RR"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/jlb.3a0618-223r"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ebiom.2022.103992"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202300184R"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.aao1818"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201800254R"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpheart.00290.2018"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.08.019"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2019.107424"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2015.04.003"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2019.104295"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-10441-8"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00395-014-0444-7"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.21608\/besps.2025.347094.1193"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-12-386456-7.01811-6"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1111\/BPH.15178"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0828-282x(08)71027-4"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.111.300502"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.116.3.381"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/emmm.201202382"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.2194"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.2147\/dddt.S188654"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1103483"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1161\/circresaha.116.307308"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature13479"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.06-7227rev"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.smim.2015.03.004"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.11-201442"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni1276"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20081880"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.2337\/db12-0684"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.201700109R"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11897-017-0337-9"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a002980"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yjmcc.2013.04.023"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp088"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cjca.2019.04.002"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.176223"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.1177\/1753425916628618"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70318","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.70318","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70318","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T06:21:28Z","timestamp":1776320488000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.70318"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,1,15]]},"references-count":57,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/bph.70318"],"URL":"https:\/\/doi.org\/10.1111\/bph.70318","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,1,15]]},"assertion":[{"value":"2025-07-29","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-01","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}