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In clinical practice, the treatment of gout has long relied on Western medicines. However, they exhibit a single mechanism of action for gout treatment and may increase the burden on target organs (e.g. allopurinol\u2010induced liver injury and benzbromarone\u2010associated elevated risk of kidney stones), which easily leads to the formation of a vicious cycle of \u2018hyperuricaemia \u2013gouty arthritis \u2013 tissue damage\u2019. This article summarized 129 natural products (NPs) (i.e. monomers) for gout treatment published up to August 2025, focusing on their potential mechanisms underlying the regulation of uric acid metabolism and inhibition of gouty arthritis, as well as their protective effects on target organs (i.e. improving renal function and restoring the balance of gut microbiota). Besides, the potential and prospects of NPs based on nanomaterials for gout treatment have been pointed out. In conclusion, this article comprehensively reviewed the treatment of gout by NPs through the synergistic effect of \u2018pathogenic mechanism regulation \u2010 target organ protection\u2019. This review will provide a reference for improving the prognosis of gout patients and breaking through the limitations of existing therapeutic approaches.<\/jats:p>","DOI":"10.1111\/bph.70342","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T09:48:14Z","timestamp":1772963294000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Natural products (NPs) for gout treatment in multiple targets and pathways"],"prefix":"10.1111","author":[{"given":"Xin","family":"Sun","sequence":"first","affiliation":[{"name":"State Key laboratory of Integration and Innovation for Classic formula and Modern Chinese Medicine, National Chinmedomics Research Center, Metabolomics Laboratory, Department of Pharmaceutical Analysis Heilongjiang University of Chinese Medicine  Harbin China"},{"name":"State Key Laboratory of Dampness Syndrome of Chinese Medicine, The Second Affiliated Hospital of Guangzhou 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