{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T06:56:53Z","timestamp":1776322613310,"version":"3.50.1"},"reference-count":60,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,4]],"date-time":"2026-02-04T00:00:00Z","timestamp":1770163200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32071174"],"award-info":[{"award-number":["32071174"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32200941"],"award-info":[{"award-number":["32200941"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32371183"],"award-info":[{"award-number":["32371183"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005236","name":"Chinese Universities Scientific Fund","doi-asserted-by":"publisher","award":["2024JCYJ001"],"award-info":[{"award-number":["2024JCYJ001"]}],"id":[{"id":"10.13039\/501100005236","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005236","name":"Chinese Universities Scientific Fund","doi-asserted-by":"publisher","award":["2024YJSY002"],"award-info":[{"award-number":["2024YJSY002"]}],"id":[{"id":"10.13039\/501100005236","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005236","name":"Chinese Universities Scientific Fund","doi-asserted-by":"publisher","award":["2025KYPT03"],"award-info":[{"award-number":["2025KYPT03"]}],"id":[{"id":"10.13039\/501100005236","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2026,5]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>\n                      Regular physical activity is an effective non\u2010pharmacological approach to hypertension management and maternal exercise improves offspring cardiovascular health, although mechanisms remain unclear. A\u2010kinase anchoring protein 150 (AKAP150) targets protein kinase C\u03b1 to L\u2010type Ca\n                      <jats:sup>2+<\/jats:sup>\n                      channels (Ca\n                      <jats:sub>V<\/jats:sub>\n                      1.2), enhancing vascular tone in arterial smooth muscle during hypertension. This study aims to uncover a novel mechanism in which epigenetic modifications of the AKAP150 gene (\n                      <jats:italic>Akap5<\/jats:italic>\n                      ) mediate the beneficial effects of maternal exercise on vascular function in hypertensive offspring.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>\n                      Pregnant spontaneously hypertensive rats (SHRs) and smooth muscle\u2010specific AKAP150 knock\u2010in mice (AKAP150 smKI) were assigned to sedentary or exercise groups. Mesenteric arteries (MAs) from embryonic day 21 and 3\u2010month\u2010old offspring were analysed for vascular function, electrophysiology, gene expression and\n                      <jats:italic>Akap5<\/jats:italic>\n                      promoter histone acetylation.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Maternal exercise during pregnancy significantly reduced blood pressure and Ca\n                      <jats:sub>v<\/jats:sub>\n                      1.2 channel function in adult male offspring of both SHR and AKAP150 smKI, but not in female SHR offspring. Maternal exercise significantly attenuated AKAP150\u2010Ca\n                      <jats:sub>v<\/jats:sub>\n                      1.2 association in mesenteric arterial myocyte from SHR offspring. Additionally, it decreased H3K9ac at the\n                      <jats:italic>Akap5<\/jats:italic>\n                      gene promoter, with a concomitant decrease in AKAP150 protein and mRNA expressions in hypertensive offspring. Furthermore, maternal exercise activated AMPK that up\u2010regulated silent information regulator 1 (sirtuin 1; SIRT1) in the mesenteric arteries of SHR offspring.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications<\/jats:title>\n                    <jats:p>\n                      Maternal exercise improves blood pressure and vascular function in adult male hypertensive offspring by deacetylating H3K9ac at the\n                      <jats:italic>Akap5<\/jats:italic>\n                      promoter via AMPK\/SIRT1 activation. This highlights prenatal exercise as a potential strategy to mitigate the intergenerational transmission of hypertension.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70346","type":"journal-article","created":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T07:55:23Z","timestamp":1770278123000},"page":"2592-2612","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Maternal exercise improves vascular function in hypertensive offspring via A\u2010kinase anchoring protein 150 gene (\n                    <i>Akap5<\/i>\n                    ) epigenetic modifications"],"prefix":"10.1111","volume":"183","author":[{"given":"Fang","family":"Qiu","sequence":"first","affiliation":[{"name":"Department of Exercise Physiology Beijing Sport University  Beijing China"},{"name":"Laboratory of Sports Stress and Adaptation of General Administration of Sport Beijing Sport University  Beijing China"},{"name":"School of Physical Education and Health Shanghai University of International Business and Economics  Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology Beijing Sport University  Beijing China"},{"name":"Laboratory of Sports Stress and Adaptation of General Administration of Sport Beijing Sport University  Beijing China"},{"name":"Key Laboratory of Physical Fitness and Exercise, Ministry of Education Beijing Sport University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meiling","family":"Shan","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology Beijing Sport University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaqi","family":"Cao","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology Beijing Sport University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zihan","family":"Fan","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology Beijing Sport University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhaoxia","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology Beijing Sport University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaozhen","family":"Ding","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology Beijing Sport University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiaodong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology Beijing Sport University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lijun","family":"Shi","sequence":"additional","affiliation":[{"name":"Department of Exercise Physiology Beijing Sport University  Beijing China"},{"name":"Laboratory of Sports Stress and Adaptation of General Administration of Sport Beijing Sport University  Beijing China"},{"name":"Key Laboratory of Physical Fitness and Exercise, Ministry of Education Beijing Sport University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,2,4]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16181"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16178"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14112"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpregu.00231.2016"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvaa226"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43032-020-00302-7"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(21)00221-X"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.115.010652"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.36.6.1018"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature07813"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2010.02.006"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.16173"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.119.312004"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.34.4.931"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.17441"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.12379"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2016.00461"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/JAHA.124.035375"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0b013e32835050ca"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00109-013-1111-4"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/bs.apha.2016.08.002"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2018.01.003"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-020-69451-8"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23158167"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2013.01.008"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2021.03.004"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42255-020-00274-7"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1203\/00006450-199712000-00007"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/abbs\/gmq104"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1111\/BPH.15178"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.atherosclerosis.2018.07.016"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2019.01173"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000003480"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.earlhumdev.2010.03.002"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurjpc\/zwaf100"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00015.2015"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2021.105877"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.107.167809"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.3791\/66577"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0808759105"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP274604"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1111\/apha.12206"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2023.115412"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.redox.2020.101467"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2022.06.003"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.320259"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1042\/BJ20082055"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrcardio.2017.155"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-011112-140204"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41440-022-01124-7"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.24613"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13035"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.123.319833"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.hyp.30.3.714"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP277698"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19061744"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.537519"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms17040451"},{"key":"e_1_2_13_61_1","doi-asserted-by":"publisher","DOI":"10.1161\/ATVBAHA.124.319543"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70346","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.70346","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70346","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T06:22:13Z","timestamp":1776320533000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.70346"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,4]]},"references-count":60,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2026,5]]}},"alternative-id":["10.1111\/bph.70346"],"URL":"https:\/\/doi.org\/10.1111\/bph.70346","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,4]]},"assertion":[{"value":"2025-04-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-12-30","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}