{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T19:13:08Z","timestamp":1792696388347,"version":"4.5.0"},"reference-count":59,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T00:00:00Z","timestamp":1771545600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["1\u201019\u2010JDF\u2010082"],"award-info":[{"award-number":["1\u201019\u2010JDF\u2010082"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["1\u201025\u2010PDF\u2010128"],"award-info":[{"award-number":["1\u201025\u2010PDF\u2010128"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["7\u201020\u2010IBS\u2010218"],"award-info":[{"award-number":["7\u201020\u2010IBS\u2010218"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000041","name":"American Diabetes Association","doi-asserted-by":"publisher","award":["7\u201021\u2010PDF\u2010158"],"award-info":[{"award-number":["7\u201021\u2010PDF\u2010158"]}],"id":[{"id":"10.13039\/100000041","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["19IPLOI34760325"],"award-info":[{"award-number":["19IPLOI34760325"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["23IPA1046810"],"award-info":[{"award-number":["23IPA1046810"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000968","name":"American Heart Association","doi-asserted-by":"publisher","award":["24TPA12988803"],"award-info":[{"award-number":["24TPA12988803"]}],"id":[{"id":"10.13039\/100000968","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"Abstract<\/jats:title>\n \n Background and Purpose<\/jats:title>\n Diabetic cardiomyopathy is a clinical condition of ventricular dysfunction, with obesity and insulin resistance as the primary risk factors. Under this condition, the heart encounters lipotoxicity, which impairs cardiac insulin sensitivity and leads to cardiomyopathy. Angiotensin\u2010(1\u20139) is a peptide of the counter\u2010regulatory axis of the renin\u2010angiotensin system with cardioprotective effects. However, its role in diabetic cardiomyopathy is unknown.<\/jats:p>\n <\/jats:sec>\n \n Experimental Approach<\/jats:title>\n To investigate the role of angiotensin\u2010(1\u20139), we first induced lipotoxic stress in the heart by high\u2010fat diet (HFD) feeding in mice. Angiotensin\u2010(1\u20139) was then administered for 4\u00a0weeks using osmotic mini\u2010pumps. Cardiac function was assessed, and insulin sensitivity was evaluated in heart tissues after insulin bolus injection. Moreover, lipotoxic stress in vitro was modelled by high glucose medium plus palmitate in neonatal rat ventricular myocytes (NRVMs).<\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n Angiotensin\u2010(1\u20139) improves myocardial function and reverts pathological cardiac remodelling under HFD feeding in mice. Moreover, angiotensin\u2010(1\u20139) enhances whole\u2010body glucose tolerance and reduces homeostatic model assessment of insulin resistance (HOMA\u2010IR). We demonstrate that angiotensin\u2010(1\u20139) increases insulin sensitivity in the heart and skeletal muscle but not in adipose tissue or the liver. Mechanistically, angiotensin\u2010(1\u20139) does not affect insulin signalling in cardiomyocytes at baseline, whereas it significantly improves insulin action under lipotoxic stress through AT\n 2<\/jats:sub>\n receptors and protein kinase A.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion and Implications<\/jats:title>\n These findings demonstrate that angiotensin\u2010(1\u20139) improves cardiac function under metabolic challenge and promotes insulin signalling in cardiomyocytes under lipotoxicity, which may shed light on the therapeutic exploration against diabetic cardiomyopathy.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bph.70356","type":"journal-article","created":{"date-parts":[[2026,2,20]],"date-time":"2026-02-20T09:50:52Z","timestamp":1771581052000},"page":"3032-3048","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Angiotensin\u2010(1\u20139) attenuates diabetic cardiomyopathy by improving insulin resistance"],"prefix":"10.1111","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2676-2674","authenticated-orcid":false,"given":"Ignacio","family":"Norambuena\u2010Soto","sequence":"first","affiliation":[{"name":"Department of Diabetes and Cancer Metabolism Beckman Research Institute of the City of Hope Duarte California USA"},{"name":"Advanced Center for Chronic Diseases (ACCDiS), Facultad Ciencias Qu\u00edmicas y Farmac\u00e9uticas & Facultad Medicina Universidad de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9776-137X","authenticated-orcid":false,"given":"Pengfei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Cancer Metabolism Beckman Research Institute of the City of Hope Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2508-7881","authenticated-orcid":false,"given":"Yin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Cancer Metabolism Beckman Research Institute of the City of Hope Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8329-4304","authenticated-orcid":false,"given":"Ling","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Cancer Metabolism Beckman Research Institute of the City of Hope Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-2545-9113","authenticated-orcid":false,"given":"Danica","family":"Jimenez\u2010Gallegos","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases (ACCDiS), Facultad Ciencias Qu\u00edmicas y Farmac\u00e9uticas & Facultad Medicina Universidad de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7153-0007","authenticated-orcid":false,"given":"Yunqiu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Cancer Metabolism Beckman Research Institute of the City of Hope Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivian","family":"Yuan","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Cancer Metabolism Beckman Research Institute of the City of Hope Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9821-0297","authenticated-orcid":false,"given":"Hongliang","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of New Targets Discovery and Drug Development for Major Diseases Ganzhou Jiangxi China"},{"name":"Gannan Innovation and Translational Medicine Research Institute Gannan Medical University Ganzhou Jiangxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5174-6545","authenticated-orcid":false,"given":"Mario","family":"Chiong","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases (ACCDiS), Facultad Ciencias Qu\u00edmicas y Farmac\u00e9uticas & Facultad Medicina Universidad de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8090-1153","authenticated-orcid":false,"given":"Gerald","family":"Zapata\u2010Torres","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases (ACCDiS), Facultad Ciencias Qu\u00edmicas y Farmac\u00e9uticas & Facultad Medicina Universidad de Chile Santiago Chile"},{"name":"Centro de Modelamiento Molecular, Biof\u00edsica y Bioinform\u00e1tica (CM2B2), Facultad Ciencias Qu\u00edmicas y Farmac\u00e9uticas Universidad de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1314-5105","authenticated-orcid":false,"given":"Yingfeng","family":"Deng","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Cancer Metabolism Beckman Research Institute of the City of Hope Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0608-5087","authenticated-orcid":false,"given":"Marcelo J.","family":"Kogan","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases (ACCDiS), Facultad Ciencias Qu\u00edmicas y Farmac\u00e9uticas & Facultad Medicina Universidad de Chile Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9904-9538","authenticated-orcid":false,"given":"Zhao V.","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Diabetes and Cancer Metabolism Beckman Research Institute of the City of Hope Duarte California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4258-1483","authenticated-orcid":false,"given":"Sergio","family":"Lavandero","sequence":"additional","affiliation":[{"name":"Advanced Center for Chronic Diseases (ACCDiS), Facultad Ciencias Qu\u00edmicas y Farmac\u00e9uticas & Facultad Medicina Universidad de Chile Santiago Chile"},{"name":"Department of Biochemistry & Molecular Biology, Facultad de Ciencias Qu\u00edmicas y Farmac\u00e9uticas Universidad de Chile Santiago Chile"},{"name":"Instituto de Ciencias Biom\u00e9dicas (ICBM), Facultad de Medicina Universidad de Chile Santiago Chile"},{"name":"Cardiology Division, Department of Internal Medicine University of Texas Southwestern Medical Center Dallas Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,20]]},"reference":[{"issue":"2","key":"e_1_2_13_2_1","first-page":"S23","article-title":"The concise guide to PHARMACOLOGY 2023\/24: G protein\u2010coupled receptors","volume":"180","author":"Alexander S. P.","year":"2023","journal-title":"British Journal of Pharmacology"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16179"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16181"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.161"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14112"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2016.11.064"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI60329"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12101373"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12035-018-1272-9"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/dmrr.3123"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajprenal.00247.2014"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00592-018-1220-1"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/bty560"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehp396"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.17441"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108087"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15241"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1161\/01.RES.87.5.e1"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkae1071"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.118.10266"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.122.061322"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2010.203075"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.1161\/HYPERTENSIONAHA.111.177485"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.693167"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2018.08.045"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1192152"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.117.311586"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2017.07.008"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00311.2019"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.311371"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3317"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00497.2011"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw377"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.067606"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.121.054885"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1093\/bioinformatics\/btt656"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15178"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13059-014-0550-8"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0196-9781(02)00051-7"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers11091299"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.1006\/bbrc.2001.4695"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2018.07.022"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2020.114190"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1097\/HJH.0000000000000094"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0048387"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.2337\/db15-0399"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-019-0244-8"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.14814\/phy2.13824"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-020-0522-3"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.120.000281"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1409229111"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.118.314607"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-15640-y"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.038924"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.122.321050"},{"key":"e_1_2_13_58_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.52.8839"},{"key":"e_1_2_13_59_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.120.053125"},{"key":"e_1_2_13_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2015.03.009"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70356","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.70356","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70356","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T03:20:14Z","timestamp":1777864814000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.70356"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,20]]},"references-count":59,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/bph.70356"],"URL":"https:\/\/doi.org\/10.1111\/bph.70356","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,20]]},"assertion":[{"value":"2025-02-04","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-02","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-20","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}