{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,6]],"date-time":"2026-11-06T05:42:57Z","timestamp":1793943777132,"version":"4.8.0"},"reference-count":77,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,2,26]],"date-time":"2026-02-26T00:00:00Z","timestamp":1772064000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["MU2789\/18\u20131"],"award-info":[{"award-number":["MU2789\/18\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KO 947\/20\u20131"],"award-info":[{"award-number":["KO 947\/20\u20131"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["FE1335\/3"],"award-info":[{"award-number":["FE1335\/3"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["TRR265(402170461)"],"award-info":[{"award-number":["TRR265(402170461)"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2026,6]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>\n                      Alcohol abuse and affective disorders are severe comorbid psychiatric diseases characterized by impaired brain synaptic transmission. The role of presynaptic scaffolding proteins coordinating presynaptic plasticity and neurotransmitter release, such as Bassoon (\n                      <jats:italic>Bsn<\/jats:italic>\n                      ), in the pathogenesis of these disorders remains elusive. Considering the key roles of the dopaminergic and glutamatergic systems in the pathogenesis of affective disorders and alcohol use disorder, we investigated the role of\n                      <jats:italic>Bsn<\/jats:italic>\n                      in these neuronal systems in the regulation of disease\u2010related behaviours.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>\n                      We employed two mouse models conditionally lacking\n                      <jats:italic>Bsn<\/jats:italic>\n                      in glutamatergic neurons of the forebrain or in dopaminergic neurons. Depression\u2010 and anxiety\u2010like and alcohol\u2010related behaviour was evaluated using a battery of behavioural tests in a sex\u2010specific way. Brain monoamine levels were evaluated in several brain regions of mice with\n                      <jats:italic>Bsn<\/jats:italic>\n                      deletion in dopaminergic neurons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      <jats:italic>Bsn<\/jats:italic>\n                      deletion in forebrain glutamatergic neurons reduced alcohol consumption and preserved affective state in male mice. In females, loss of\n                      <jats:italic>Bsn<\/jats:italic>\n                      in these neurons.\n                    <\/jats:p>\n                    <jats:p>\n                      enhanced anxiety\u2010like behaviour. A\n                      <jats:italic>Bsn<\/jats:italic>\n                      knockout in dopaminergic neurons of males was associated with increased alcohol consumption and anxiety, while depression\u2010like behaviour was attenuated. Females with\n                      <jats:italic>Bsn<\/jats:italic>\n                      deletion in dopaminergic neurons showed no alterations in affective state and alcohol drinking behaviour, but increased dopamine levels in amygdala, indicating a potentially compensatory mechanism.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Implications<\/jats:title>\n                    <jats:p>\n                      Our findings suggest that\n                      <jats:italic>Bsn<\/jats:italic>\n                      is a sex\u2010specific regulator of affective state and alcohol consumption behaviour in a neuron type\u2010specific way.\n                      <jats:italic>Bsn<\/jats:italic>\n                      exerts dissociating behavioural effects depending on its action in glutamatergic versus dopaminergic neurons.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70384","type":"journal-article","created":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:09:15Z","timestamp":1772989755000},"page":"3111-3128","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Dissociating role of Bassoon in glutamatergic and dopaminergic neurons in alcohol\u2010related behaviour and affective state in mice"],"prefix":"10.1111","volume":"183","author":[{"given":"Liubov S.","family":"Kalinichenko","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Clinic Friedrich\u2010Alexander\u2010University of Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mona","family":"Krenbauer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Clinic Friedrich\u2010Alexander\u2010University of Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Janosh","family":"Isert","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Clinic Friedrich\u2010Alexander\u2010University of Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marlon","family":"Kamlah","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Clinic Friedrich\u2010Alexander\u2010University of Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thorben","family":"Tanzer","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Clinic Friedrich\u2010Alexander\u2010University of Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hannes","family":"R\u00f6del","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Clinic Friedrich\u2010Alexander\u2010University of Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Clinic Friedrich\u2010Alexander\u2010University of Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6743-8627","authenticated-orcid":false,"given":"Anil","family":"Annamneedi","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Neurobiology (LIN)  Magdeburg Germany"},{"name":"School of Arts and Sciences Sai University  Paiyanur India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan Ya\u011f\u0131z","family":"Buchholz","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Clinic Friedrich\u2010Alexander\u2010University of Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Volker","family":"Eulenburg","sequence":"additional","affiliation":[{"name":"Department for Translational Anaesthesiology and Intensive Care Medicine, Medical Faculty University of Augsburg  Augsburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernd","family":"Lenz","sequence":"additional","affiliation":[{"name":"Department of Addictive Behavior and Addiction Medicine, Central Institute of Mental Health, Medical Faculty Mannheim University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eckart D.","family":"Gundelfinger","sequence":"additional","affiliation":[{"name":"Leibniz Institute for Neurobiology (LIN)  Magdeburg Germany"},{"name":"Center of Behavioral Brain Sciences Otto\u2010von\u2010Guericke University  Magdeburg Germany"},{"name":"Institute for Pharmacology &amp; Toxicology, Medical Faculty Otto\u2010von\u2010Guericke University  Magdeburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johannes","family":"Kornhuber","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Clinic Friedrich\u2010Alexander\u2010University of Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Fejtova","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Clinic Friedrich\u2010Alexander\u2010University of Erlangen\u2010N\u00fcrnberg  Erlangen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christian P.","family":"M\u00fcller","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychotherapy, University Clinic Friedrich\u2010Alexander\u2010University of Erlangen\u2010N\u00fcrnberg  Erlangen Germany"},{"name":"Institute of Psychopharmacology, Central Institute of Mental Health University of Heidelberg  Heidelberg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,2,26]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.201540434"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70233"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70235"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70231"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0896-6273(03)00088-6"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-018-1692-3"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22157944"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/dvg.20228"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41583-021-00513-0"},{"key":"e_1_2_12_11_1","unstructured":"Benton R. L.(1989).Planned Comparisons as Better Alternatives to ANOVA Omnibus Tests 19"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(01)00743-9"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2023.106324"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.9b00325"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105159"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13041-024-01105-6"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-82600-x"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.17441"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2009.01.031"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(18)30337-7"},{"key":"e_1_2_12_21_1","first-page":"108","article-title":"Alcohol and dopamine","volume":"21","author":"Di Chiara G.","year":"1997","journal-title":"Alcohol Health and Research World"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.201201038"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2015.00018"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9020313"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-0682-4"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112978"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcp.2007.06.039"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2019.00337"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01204-1"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsyn.2015.00019"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajhg.2025.04.011"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1037\/h0073676"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.10.026"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-011-1233-3"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)35324-8"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.115.2.291"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP271826"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3786-05.2006"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2013.01.003"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhac106"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-021-01304-w"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nbd.2025.106800"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2008.07.011"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15178"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2019.07.033"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2006.04.003"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(97)00113-9"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3714-04.2004"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(94)90299-2"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-020-03590-z"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.15252\/embr.202153659"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0140525X11000057"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-023-02074-3"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-022-01464-5"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2017.01.026"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.06.003"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.12.020"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0153097"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/0741-8329(91)90854-P"},{"key":"e_1_2_12_61_1","first-page":"25","volume-title":"Applied analysis of variance in behavioral science","author":"Ramsey P.","year":"1993"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0149-7634(89)80025-9"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-025-03226-3"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0385-4"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(91)90379-3"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.01.017"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1111\/and.14153"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41380-025-03210-x"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0641-7"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02362037"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13293-024-00592-5"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(96)00510-3"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/emboj.2013.27"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1111\/neup.13009"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4749-06.2007"},{"issue":"1","key":"e_1_2_12_76_1","article-title":"The downregulation of autophagy in amygdala is sufficient to alleviate anxiety\u2010like behaviors in post\u2010traumatic stress disorder model mice","volume":"15","author":"Wang W.","year":"2024","journal-title":"Translational Psychiatry"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1360-0443.2000.95225112.x"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.2174\/1570159X13666150326003852"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70384","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.70384","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70384","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,30]],"date-time":"2026-10-30T05:52:45Z","timestamp":1793339565000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.70384"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2,26]]},"references-count":77,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2026,6]]}},"alternative-id":["10.1111\/bph.70384"],"URL":"https:\/\/doi.org\/10.1111\/bph.70384","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,2,26]]},"assertion":[{"value":"2025-09-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-01-31","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-02-26","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}