{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T23:27:28Z","timestamp":1792106848682,"version":"4.4.0"},"reference-count":50,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T00:00:00Z","timestamp":1777420800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004479","name":"Natural Science Foundation of Jiangxi Province","doi-asserted-by":"publisher","award":["20252BAC240575"],"award-info":[{"award-number":["20252BAC240575"]}],"id":[{"id":"10.13039\/501100004479","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background and purpose<\/jats:title>\n                    <jats:p>\n                      Sepsis\u2010induced acute lung injury (ALI) is driven by macrophage\u2010mediated inflammation and PANoptosis.\n                      <jats:italic>Eucommia ulmoides<\/jats:italic>\n                      Oliv. (Du Zhong, DZ) contains anti\u2010inflammatory phytochemicals, but crude extracts show poor solubility, rapid clearance and a narrow therapeutic window. We therefore tested whether a nanoliposomal DZ formulation (Nano\u2010LP\u2010DZ) could improve efficacy in experimental sepsis\u2010induced ALI.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental approach<\/jats:title>\n                    <jats:p>Nano\u2010LP\u2010DZ was prepared by double\u2010emulsion ultrasonication and characterised physicochemically. Its effects were evaluated in lipopolysaccharide\u2010stimulated macrophages, macrophages stimulated with Oxo plus lipopolysaccharide, and in mice subjected to caecal ligation and puncture (CLP). Cytokine release, lung injury and macrophage survival were assessed together with markers of pyroptosis, apoptosis and necroptosis. Upstream regulation was examined using TGF\u2010\u03b21 knockdown, TGF\u2010\u03b2 receptor blockade, JNK inhibition, and transcriptomic analyses.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>Compared with the unformulated extract, Nano\u2010LP\u2010DZ preserved macrophage viability at pharmacologically active concentrations, more effectively reduced interleukin\u20101\u03b2, interleukin\u20106 and tumour necrosis factor\u2010\u03b1 release, and alleviated CLP\u2010induced lung oedema, neutrophil infiltration and histopathological damage. Nano\u2010LP\u2010DZ restored TGF\u2010\u03b21 expression in macrophages under septic stress and induced phosphorylation of JNK and its substrate Bim. These changes were accompanied by suppression of PANoptosis, with reduced caspase\u20101, gasdermin D and E, caspase\u20108, caspase\u20103, caspase\u20107 and phospho\u2010MLKL signalling. Silencing TGF\u2010\u03b21, blocking its receptor or inhibiting JNK markedly inhibited these protective effects.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and implications<\/jats:title>\n                    <jats:p>Nano\u2010LP\u2010DZ broadens the therapeutic window and enhances the anti\u2010inflammatory efficacy of DZ in sepsis\u2010induced ALI by engaging a macrophage TGF\u2010\u03b21\u2013JNK pathway that restrains PANoptosis. These findings identify TGF\u2010\u03b21\u2013JNK as a druggable upstream checkpoint in sepsis\u2010associated lung injury.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70393","type":"journal-article","created":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T02:01:36Z","timestamp":1777514496000},"page":"4381-4398","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Nanoliposomal\n                    <scp>\n                      <i>Eucommia ulmoides<\/i>\n                    <\/scp>\n                    extract limits PANoptosis in sepsis\u2010induced acute lung injury through a TGF\u2010\u03b21\u2013JNK pathway"],"prefix":"10.1111","volume":"183","author":[{"given":"Mingtao","family":"Deng","sequence":"first","affiliation":[{"name":"Department of Critical Care Medicine, Shangrao Key Laboratory of Acute and Critical Care Medicine, The Central Hospital of Shangrao The First Affiliated Hospital of Jiangxi Medical College  Shangrao China"},{"name":"Department of Medical Technology Jiangxi Medical College  Shangrao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zheren","family":"Tong","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences Zhejiang University of Technology  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Medical Technology Jiangxi Medical College  Shangrao China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Siqi","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Critical Care Medicine, Shangrao Key Laboratory of Acute and Critical Care Medicine, The Central Hospital of Shangrao The First Affiliated Hospital of Jiangxi Medical College  Shangrao China"},{"name":"Department of Medical Technology Jiangxi Medical College  Shangrao 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