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Our team has designed and developed therapeutic vaccines, ILRQ\u03b2\u2010007 and ILRQ\u03b2\u2010008, which target interleukin\u20101 receptor, type I (IL\u20101R1). The aim of this study is to investigate the effect of the vaccines on short\u2010term and long\u2010term MI animal models.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>The ILRQ\u03b2\u2010007 and ILRQ\u03b2\u2010008 vaccines were prepared and then used to immunize C57BL\/6J (C57) mice with MI and observed their effects at 7 and 28\u2009days, respectively. Cardiac ultrasound and histological staining were used to assess cardiac function and remodelling after MI in C57 mice. Flow cytometry and molecular biology tests were used to evaluate the systemic inflammatory infiltrate. While transesophageal catheter pacing was used to assess susceptibility to atrial fibrillation in mice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The vaccines produced high titres of antibodies and reduced IL\u20101R1 expression levels in the heart after MI. They significantly reduced myocardial infarct size and systemic inflammation following short\u2010term MI, as well as protecting cardiac function and reducing cardiac fibrosis following long\u2010term MI. Moreover, the susceptibility to atrial fibrillation was reduced in both the short and long\u2010term models. Further, the vaccines improved mitochondrial dynamics and thus maintained mitochondrial homeostasis protecting the heart.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Implications<\/jats:title>\n                    <jats:p>This study demonstrates that vaccines targeting IL\u20101R1 can be applied to the prevention and treatment of MI, providing a new direction for MI research.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70436","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T07:56:21Z","timestamp":1777708581000},"page":"4628-4645","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Effects of vaccines targeting interleukin\u20101 receptor, type I on atrial and ventricular function after myocardial 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