{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:13:14Z","timestamp":1783674794590,"version":"3.55.0"},"reference-count":51,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["24K12075"],"award-info":[{"award-number":["24K12075"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2026,7]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>\n                      Perioperative neurocognitive disorder is a serious complication, in which general anaesthesia is a major contributor. Disruption of neuronal Ca\n                      <jats:sup>2+<\/jats:sup>\n                      homeostasis, potentially involving store\u2010operated Orai1 channels, is one proposed mechanism. The study investigated the role of Orai1 channels in inhibitory neurons.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>Behavioural data before and 1\u00a0h after general anaesthesia (1 minimum alveolar concentration (MAC) for 30\u2009min) were compared in wild\u2010type (WT) and knockout (KO) mice, in which Orai1 was specifically deleted in inhibitory interneurons. To examine the underlying mechanisms, electrophysiological studies were performed using brain slices and hippocampal neuroinflammation was assessed by enzyme\u2010linked immunosorbent assay.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>The success rate of the Y\u2010maze test significantly decreased after sevoflurane anaesthesia in WT but not in KO mice, with similar results after isoflurane and longer duration sevoflurane (1\u00a0h) anaesthesia. Hippocampal long\u2010term potentiation showed a similar reduction after sevoflurane in WT but not in KO mice. Whole\u2010cell patch\u2010clamp recordings from CA1 interneurons revealed that the sevoflurane\u2010induced increase in the frequency of spontaneous inhibitory postsynaptic currents in WT was diminished by tetrodotoxin, whereas no significant increase was observed in KO mice. Hippocampal TNF\u03b1 levels were significantly higher after sevoflurane in WT but not in KO mice. Pre\u2010administration of an Orai1 channel inhibitor showed a similar decrease in the Y\u2010maze test after sevoflurane anaesthesia.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Implications<\/jats:title>\n                    <jats:p>Store\u2010operated Orai1 channels in inhibitory neurons could play a critical role in delayed recovery following general anaesthesia, potentially by regulating action potential generation. Pharmacological inhibition of the channels may prevent perioperative neurocognitive disorder.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70438","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T07:09:18Z","timestamp":1775027358000},"page":"3651-3665","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["A potential mechanism and strategy for accelerating recovery of neurocognitive function after general anaesthesia through store\u2010operated Orai1 channels"],"prefix":"10.1111","volume":"183","author":[{"given":"Ryota","family":"Watanabe","sequence":"first","affiliation":[{"name":"Department of Anesthesiology Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1382-0369","authenticated-orcid":false,"given":"Kotaro","family":"Hori","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukimi","family":"Kira","sequence":"additional","affiliation":[{"name":"Research Support Platform Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shogo","family":"Tsujikawa","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideki","family":"Hino","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tadashi","family":"Matsuura","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Mori","sequence":"additional","affiliation":[{"name":"Department of Anesthesiology Osaka Metropolitan University Graduate School of Medicine  Osaka Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,4,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1097\/EJA.0000000000000594"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70231"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1149213"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcpt.13322"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12871-019-0903-7"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-022-03964-8"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051431"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3892\/etm.2018.5976"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.17441"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3007-17.2017"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000003514"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2017.11.087"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/aas.12651"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706441"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2018.09.003"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2019.05.001"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1213\/ane.0000000000000011"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1080\/15563650.2021.2020280"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1113\/JP280119"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2016.03.005"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1097\/ALN.0b013e318164cfba"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bja.2020.06.063"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-018-0033-7"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2012.08.001"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn2207"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2012.07.030"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1111\/BPH.15178"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0195659"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0567-18.2018"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108464"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-017-02642-6"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13054-020-03220-x"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex354"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1097\/00000542-200102000-00025"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00020.2014"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2017.03.005"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3973-16.2017"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1112923"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0263-14.2014"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1093\/bja\/aex130"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceca.2018.07.005"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1213\/ANE.0000000000004053"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0361-9230(01)00428-2"},{"key":"e_1_2_12_46_1","first-page":"143","article-title":"Guiding principles for the care and use of animals in the field of physiological sciences","volume":"64","author":"The Physiological Society of Japan","year":"2002","journal-title":"Japanese Journal of Physiology"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1186\/1742-2094-9-155"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/sciadv.ade7002"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706444"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.2174\/156720509787313934"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-020-00223-4"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16404"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70438","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.70438","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70438","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T08:15:49Z","timestamp":1783671349000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.70438"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":51,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2026,7]]}},"alternative-id":["10.1111\/bph.70438"],"URL":"https:\/\/doi.org\/10.1111\/bph.70438","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]},"assertion":[{"value":"2025-06-10","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-03-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-01","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}