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The number of obese individuals has increased dramatically and, even in Switzerland which may be considered a relatively \u201clean\u201d country, the numbers are alarmingly high and have reached almost 50% of the adult population. There is an urgent need for effective, safe and widely\u2010available therapeutic interventions worldwide. The development of analogues of physiological gut hormones has led to highly effective treatment options based on two incretins: glucagon\u2010like peptide\u20101 (GLP\u20101) and glucose\u2010dependent insulinotropic peptide (GIP). Analogues of the pancreatic hormone amylin, next to the above incretins and glucagon, have yielded more promising body weight\u2010lowering effects in preclinical and clinical studies, and several new amylin analogues are under development. Despite progress in anti\u2010obesity pharmacotherapy, major challenges remain. Here, I discuss recent findings in the amylin field, including amylin's potential role in improving memory, and the characterisation of specific neurons and circuits involved in amylin signalling in the caudal hindbrain. This is followed by a more in\u2010depth discussion of challenges linked to amylin pharmacotherapy, or anti\u2010obesity pharmacotherapy in general. Three of these challenges are addressed, specifically: (1) What are the potential mechanisms of the muscle sparing effect of amylin\u2010based weight loss drugs? (2) Is there improved weight loss effectiveness of amylin\u2010based anti\u2010obesity therapy in type 2 diabetes mellitus (T2D) patients compared with incretin\u2010based approaches? (3) Can amylin analogues improve maintenance of reduced body weight after the weight loss phase because of their role as leptin sensitiser?<\/jats:p>","DOI":"10.1111\/bph.70484","type":"journal-article","created":{"date-parts":[[2026,5,2]],"date-time":"2026-05-02T06:20:37Z","timestamp":1777702837000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Amylin analogues as a novel perspective in anti\u2010obesity therapy"],"prefix":"10.1111","author":[{"given":"Thomas A.","family":"Lutz","sequence":"first","affiliation":[{"name":"Institute of Veterinary Physiology Vetsuisse Faculty University of Zurich  Zurich Switzerland"},{"name":"One Health Institute Vetsuisse Faculty University of Zurich  Zurich 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