{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T09:14:37Z","timestamp":1783674877296,"version":"3.55.0"},"reference-count":56,"publisher":"Wiley","issue":"16","license":[{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,5,25]],"date-time":"2026-05-25T00:00:00Z","timestamp":1779667200000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473522"],"award-info":[{"award-number":["82473522"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82504263"],"award-info":[{"award-number":["82504263"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2026,8]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by oxidative stress and immune dysregulation. Fibroblast growth factor\u2010inducible 14 (Fn14) has been implicated in tissue injury, but its specific role in SLE pathogenesis remains unclear. This study investigates whether Fn14 modulates disease severity by driving oxidative stress and the subsequent imbalance of Th17\/Treg cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>\n                      Lupus was induced in both wild\u2010type and Fn14 knockout mice via pristane administration. Disease severity was evaluated through lupus nephritis, skin lesions and arthritis, along with oxidative stress markers. Proteomic analysis of kidney tissue identified dysregulated redox\u2010regulatory proteins.\n                      <jats:italic>In vitro<\/jats:italic>\n                      , TWEAK\u2010pretreated mouse glomerular mesangial cells were assessed for Fn14\u2010mediated oxidative responses. Flow cytometry quantified the impact of Fn14 on the balance of Th17 and Treg cells.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      Fn14\u2010deficient mice exhibited significantly reduced lupus severity across all affected organs. This protection was accompanied by decreased oxidative stress markers and increased NRF2 levels. Proteomic analysis confirmed that Fn14 deficiency reversed the dysregulation of multiple redox\u2010regulatory proteins in kidney tissue.\n                      <jats:italic>In vitro<\/jats:italic>\n                      , TWEAK pretreatment sensitized mesangial cells to oxidative challenge, potentiating reactive oxygen species (ROS) generation while simultaneously suppressing antioxidant defences. Furthermore, Fn14 deficiency corrected the Th17\/Treg imbalance associated with oxidative stress.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion and Implications<\/jats:title>\n                    <jats:p>Fn14 deficiency alleviates lupus severity by mitigating oxidative stress and correcting the Th17\/Treg imbalance. The TWEAK\/Fn14 axis promotes oxidative injury by priming target cells for exaggerated pro\u2010oxidant responses while compromising antioxidant systems. These results highlight the therapeutic potential of targeting Fn14 to counteract oxidative stress and immune dysregulation in SLE.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70506","type":"journal-article","created":{"date-parts":[[2026,5,26]],"date-time":"2026-05-26T03:05:47Z","timestamp":1779764747000},"page":"5102-5119","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fn14 signalling participates in pristane\u2010induced murine lupus through exacerbating oxidative stress"],"prefix":"10.1111","volume":"183","author":[{"given":"Zhu","family":"Yan","sequence":"first","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"},{"name":"Department of Plastic Surgery Xijing Hospital, Fourth Military Medical University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongfang","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mai","family":"Luo","sequence":"additional","affiliation":[{"name":"Core Research Laboratory The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaqi","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Zhejiang University School of Medicine  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qin","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yufei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yale","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yumin","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Dermatology The Second Affiliated Hospital of Xi'an Jiaotong University  Xi'an China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,5,25]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.00408"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70234"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70233"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70229"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14112"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep03625"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e23223"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.117689"},{"key":"e_1_2_13_10_1","doi-asserted-by":"publisher","DOI":"10.1128\/spectrum.03172-22"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.17441"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12026-024-09535-z"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12868-023-00839-8"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2023.175823"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/exd.13108"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41584-024-01179-5"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.3390\/molecules22010134"},{"key":"e_1_2_13_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.freeradbiomed.2018.03.049"},{"key":"e_1_2_13_19_1","doi-asserted-by":"publisher","DOI":"10.1186\/s10020-022-00514-4"},{"key":"e_1_2_13_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2023.115925"},{"key":"e_1_2_13_21_1","doi-asserted-by":"publisher","DOI":"10.1177\/09603271231200868"},{"key":"e_1_2_13_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/genes12020251"},{"key":"e_1_2_13_23_1","doi-asserted-by":"publisher","DOI":"10.1089\/ars.2011.4073"},{"key":"e_1_2_13_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms19030730"},{"key":"e_1_2_13_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/0961203313492869"},{"key":"e_1_2_13_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29838"},{"key":"e_1_2_13_27_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15178"},{"key":"e_1_2_13_28_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.635021"},{"key":"e_1_2_13_29_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2017.8090"},{"key":"e_1_2_13_30_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox12081627"},{"key":"e_1_2_13_31_1","doi-asserted-by":"publisher","DOI":"10.3390\/antiox13101224"},{"key":"e_1_2_13_32_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13075-025-03659-9"},{"key":"e_1_2_13_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00651"},{"key":"e_1_2_13_34_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.70110"},{"key":"e_1_2_13_35_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvv204"},{"key":"e_1_2_13_36_1","doi-asserted-by":"publisher","DOI":"10.1038\/ni.3868"},{"key":"e_1_2_13_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clim.2006.06.001"},{"key":"e_1_2_13_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.fob.2015.06.001"},{"key":"e_1_2_13_39_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_13_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bios.2010.08.029"},{"key":"e_1_2_13_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells9081831"},{"key":"e_1_2_13_42_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.01027"},{"key":"e_1_2_13_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2024.119894"},{"key":"e_1_2_13_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.22829"},{"key":"e_1_2_13_45_1","doi-asserted-by":"publisher","DOI":"10.1093\/rheumatology\/keab824"},{"key":"e_1_2_13_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2020.554725"},{"key":"e_1_2_13_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaut.2024.103205"},{"key":"e_1_2_13_48_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd2488"},{"key":"e_1_2_13_49_1","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2014030233"},{"key":"e_1_2_13_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/1756-185X.14232"},{"key":"e_1_2_13_51_1","doi-asserted-by":"publisher","DOI":"10.2147\/JIR.S399284"},{"key":"e_1_2_13_52_1","doi-asserted-by":"publisher","DOI":"10.1155\/2016\/2526174"},{"key":"e_1_2_13_53_1","doi-asserted-by":"publisher","DOI":"10.1002\/art.23054"},{"key":"e_1_2_13_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jep.2022.115004"},{"key":"e_1_2_13_55_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.30089"},{"key":"e_1_2_13_56_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-024-06785-5"},{"key":"e_1_2_13_57_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.124.046394"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70506","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.70506","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70506","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T08:25:54Z","timestamp":1783671954000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.70506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,25]]},"references-count":56,"journal-issue":{"issue":"16","published-print":{"date-parts":[[2026,8]]}},"alternative-id":["10.1111\/bph.70506"],"URL":"https:\/\/doi.org\/10.1111\/bph.70506","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,25]]},"assertion":[{"value":"2026-02-16","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-22","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}