{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T07:06:06Z","timestamp":1779087966837,"version":"3.51.4"},"reference-count":149,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,5,17]],"date-time":"2026-05-17T00:00:00Z","timestamp":1778976000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"abstract":"<jats:p>\n                    The global obesity pandemic demands therapeutic innovation beyond incretin\u2010based pharmacotherapy. While glucagon\u2010like peptide\u20101 (GLP\u20101) receptor agonists have transformed obesity management, persistent challenges remain: gastrointestinal intolerance, weight\u2010loss plateaus and post\u2010treatment regain underscore the need for complementary and mechanistically orthogonal approaches. Fatty acid amide hydrolase (FAAH) represents a promising, though still exploratory, enzymatic target at the crossroads of appetite, reward and metabolism. This serine hydrolase regulates the degradation of both pro\u2010orexigenic endocannabinoids, notably anandamide (AEA) and anti\u2010orexigenic N\u2010acylethanolamines (NAEs), particularly oleoylethanolamide (OEA). Unlike direct cannabinoid type 1 receptor (CB\n                    <jats:sub>1<\/jats:sub>\n                    receptor) antagonists, which failed clinically due to severe psychiatric toxicity, FAAH modulation may allow a more spatially and temporally constrained regulation of endogenous lipid signalling. Importantly, FAAH inhibition does not intrinsically discriminate between orexigenic and anorexigenic substrates; thus, its metabolic impact depends on tissue selectivity, substrate bias and nutritional context. By prolonging OEA signalling, FAAH inhibition has the potential to enhance peroxisome proliferator\u2010activated receptor alpha (PPAR\n                    <jats:italic>\u03b1<\/jats:italic>\n                    ) and G protein\u2010coupled receptor 119 (GPR119) pathways, promoting fatty acid\n                    <jats:italic>\u03b2<\/jats:italic>\n                    \u2010oxidation, improving hepatic lipid handling, and amplifying nutrient\u2010dependent GLP\u20101 secretion in preclinical models. However, translational evidence in humans remains limited, and the long\u2010term metabolic efficacy of FAAH inhibition in obesity has yet to be demonstrated. This review examines FAAH biochemistry, its dysregulation in obesity, and the evolving pharmacological landscape of FAAH modulators, with particular attention to peripherally restricted and substrate\u2010biased strategies. Rather than proposing FAAH inhibition as a standalone anti\u2010obesity therapy, we discuss its potential role as a complementary component within multimodal treatment regimens alongside incretin\u2010based drugs.\n                  <\/jats:p>","DOI":"10.1111\/bph.70511","type":"journal-article","created":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:06:16Z","timestamp":1779084376000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Fatty acid amide hydrolase (FAAH) and the endocannabinoid system in obesity: Mechanistic insights and pharmacological opportunities beyond incretin\u2010based therapies"],"prefix":"10.1111","author":[{"given":"Ilaria","family":"Serra","sequence":"first","affiliation":[{"name":"Department of Physiology and Pharmacology \u201cV. Erspamer\u201d Sapienza University of Rome  Rome Italy"},{"name":"Department of Biological and Environmental Sciences and Technologies (DiSTeBA) University of Salento  Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elisa","family":"Bisconti","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies (DiSTeBA) University of Salento  Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniele","family":"Vergara","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies (DiSTeBA) University of Salento  Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna Maria","family":"Giudetti","sequence":"additional","affiliation":[{"name":"Department of Biological and Environmental Sciences and Technologies (DiSTeBA) University of Salento  Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Francesco","family":"Vari","sequence":"additional","affiliation":[{"name":"Department of Physiology and Pharmacology \u201cV. Erspamer\u201d Sapienza University of Rome  Rome Italy"},{"name":"Department of Biological and Environmental Sciences and Technologies (DiSTeBA) University of Salento  Lecce Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2026,5,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2013.01.012"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines13020502"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1517\/17460440903018857"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11892-024-01562-2"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2005.08.011"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70232"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70230"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70234"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70231"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.14-255208"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics14020338"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.106.105221"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1802251115"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1128\/iai.00020-24"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1002\/cmdc.202100757"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.7555\/JBR.38.20240053"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-018-0141-7"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11894-025-00995-3"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkw1132"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.200305129"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1124\/pr.112.006387"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0960-894X(98)00734-3"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1080\/13543776.2021.1841166"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drudis.2018.03.007"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2017.04.001"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1076535"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/2051017"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpendo.00080.2017"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddh216"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(07)61721-8"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1210\/en.2007-0966"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2020.00266"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.8b00951"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn.2632"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI17725"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.94.22.11819"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/eat.23271"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2010.01166.x"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1054\/plef.2001.0358"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/35071088"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn1457"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1104675108"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2009.166"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2215-0366(18)30427-9"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2826.2008.01683.x"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2011.11.009"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics15041105"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.12212"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M607809200"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature01921"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0036-10.2010"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300166"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.23367"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms23052781"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2023.105226"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.17925\/EE.2025.21.2.5"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnut.2025.1661603"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1210\/jc.2006-1811"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pain.2012.04.020"},{"key":"e_1_2_12_61_1","doi-asserted-by":"crossref","unstructured":"Hume C. Baglot S. L. Javorcikova L. Melts V. Bieber J. B. &Hill M. N.(2022).Characterising \u2018the munchies\u2019; effects of delta\u20109\u2010tetrahydrocannabinol (THC) vapour inhalation on feeding patterns satiety and macronutrient\u2010specific food preference in male and female rats.https:\/\/doi.org\/10.1101\/2022.09.22.509090","DOI":"10.1101\/2022.09.22.509090"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1128\/mcb.3.8.1430-1439.1983"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12298"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms22031034"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-43606-3"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M109.058461"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.3390\/dna5040059"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1152\/physrev.00019.2008"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI6223"},{"key":"e_1_2_12_70_1","first-page":"627","article-title":"Recent studies on kaempferol and its biological and pharmacological activities","volume":"19","author":"Kim J. K.","year":"2020","journal-title":"EXCLI Journal"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmc.2014.09.012"},{"key":"e_1_2_12_72_1","doi-asserted-by":"publisher","DOI":"10.1002\/prp2.70009"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.27913"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbi.2022.02.008"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1677\/JOE-08-0453"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.12839"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.2337\/db08-1237"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2012.15"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1186\/s43556-025-00400-5"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.2337\/db18-0031"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-004-4494-0"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0909411106"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.7759\/cureus.83903"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2015.07.028"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neurot.2025.e00814"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.5414\/CP202687"},{"key":"e_1_2_12_87_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph14121316"},{"key":"e_1_2_12_88_1","doi-asserted-by":"publisher","DOI":"10.1128\/jb.173.21.6694-6704.1991"},{"key":"e_1_2_12_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tem.2015.07.007"},{"key":"e_1_2_12_90_1","doi-asserted-by":"publisher","DOI":"10.1101\/lm.1145209"},{"key":"e_1_2_12_91_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M407250200"},{"key":"e_1_2_12_92_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev.biochem.74.082803.133450"},{"key":"e_1_2_12_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2016.06.021"},{"key":"e_1_2_12_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2022.101194"},{"key":"e_1_2_12_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232415502"},{"key":"e_1_2_12_96_1","doi-asserted-by":"publisher","DOI":"10.1038\/msb.2010.46"},{"key":"e_1_2_12_97_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.plipres.2025.101358"},{"key":"e_1_2_12_98_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells14070551"},{"key":"e_1_2_12_99_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12020-017-1261-1"},{"key":"e_1_2_12_100_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1209200"},{"key":"e_1_2_12_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/306203a0"},{"key":"e_1_2_12_102_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12902-024-01738-7"},{"key":"e_1_2_12_103_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn2001206"},{"key":"e_1_2_12_104_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2011.06.096"},{"key":"e_1_2_12_105_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2006.02.004"},{"key":"e_1_2_12_106_1","doi-asserted-by":"publisher","DOI":"10.1210\/er.2005-0009"},{"key":"e_1_2_12_107_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pcbi.1004231"},{"key":"e_1_2_12_108_1","doi-asserted-by":"publisher","DOI":"10.1021\/ct300611q"},{"key":"e_1_2_12_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2013.01.003"},{"key":"e_1_2_12_110_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2024.116245"},{"key":"e_1_2_12_111_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi991876p"},{"key":"e_1_2_12_112_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M001607200"},{"key":"e_1_2_12_113_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi002578r"},{"key":"e_1_2_12_114_1","doi-asserted-by":"publisher","DOI":"10.1021\/bi990637z"},{"key":"e_1_2_12_115_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrn1247"},{"key":"e_1_2_12_116_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.0c00191"},{"key":"e_1_2_12_117_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.7.761"},{"key":"e_1_2_12_118_1","doi-asserted-by":"publisher","DOI":"10.1111\/cts.12548"},{"key":"e_1_2_12_119_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms232315228"},{"key":"e_1_2_12_120_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-34696-6"},{"key":"e_1_2_12_121_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10928-022-09822-y"},{"key":"e_1_2_12_122_1","doi-asserted-by":"publisher","DOI":"10.1038\/35102582"},{"key":"e_1_2_12_123_1","doi-asserted-by":"publisher","DOI":"10.1038\/bjp.2008.335"},{"key":"e_1_2_12_124_1","doi-asserted-by":"publisher","DOI":"10.1089\/can.2021.0237"},{"key":"e_1_2_12_125_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1748-1716.2011.02280.x"},{"key":"e_1_2_12_126_1","doi-asserted-by":"publisher","DOI":"10.3390\/nu13020373"},{"key":"e_1_2_12_127_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-00888-1"},{"key":"e_1_2_12_128_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm800311k"},{"key":"e_1_2_12_129_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms26199549"},{"key":"e_1_2_12_130_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cmet.2013.03.001"},{"key":"e_1_2_12_131_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm14082851"},{"key":"e_1_2_12_132_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0802954"},{"key":"e_1_2_12_133_1","doi-asserted-by":"publisher","DOI":"10.1002\/jps.23181"},{"key":"e_1_2_12_134_1","doi-asserted-by":"publisher","DOI":"10.1111\/obr.13978"},{"key":"e_1_2_12_135_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M413473200"},{"key":"e_1_2_12_136_1","doi-asserted-by":"publisher","DOI":"10.1186\/s41232-018-0086-5"},{"key":"e_1_2_12_137_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines10102492"},{"key":"e_1_2_12_138_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.6b00538"},{"key":"e_1_2_12_139_1","doi-asserted-by":"publisher","DOI":"10.1111\/1440-1681.13238"},{"key":"e_1_2_12_140_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-030220-112741"},{"key":"e_1_2_12_141_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aaf7497"},{"key":"e_1_2_12_142_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(05)66374-X"},{"key":"e_1_2_12_143_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.accounts.9b00134"},{"key":"e_1_2_12_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jnutbio.2024.109605"},{"key":"e_1_2_12_145_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M606646200"},{"key":"e_1_2_12_146_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2032183"},{"key":"e_1_2_12_147_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706157"},{"key":"e_1_2_12_148_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.117.243808"},{"key":"e_1_2_12_149_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.nlm.2009.06.001"},{"key":"e_1_2_12_150_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jlr.2025.100754"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70511","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.70511","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70511","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T06:06:19Z","timestamp":1779084379000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.70511"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5,17]]},"references-count":149,"alternative-id":["10.1111\/bph.70511"],"URL":"https:\/\/doi.org\/10.1111\/bph.70511","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,5,17]]},"assertion":[{"value":"2026-02-06","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-04-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-05-17","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"bph.70511"}}