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Within this network, sulphur\u2010based biology, centred on hydrogen sulphide and related reactive sulphur species, has emerged as a key regulator of metabolic homeostasis, vascular tone, inflammatory response and mitochondrial function. Here, we review the chemical and mechanistic landscape of sulphaceutics (pharmacological sulphur\u2010releasing agents) and sulphanutraceutics (diet\u2010derived organosulphur compounds), focusing on their capacity to reprogramme peripheral dysfunctions in obesity. Evidence from experimental models, also supported by emerging human data, indicates that sulphur\u2010based interventions can enhance skeletal muscle insulin signalling and performance, restore endothelial reactivity and reduce vascular inflammation, thereby modulating adipose expansion and inflammatory tone. These actions reflect the engagement of upstream redox\u2010sensitive regulatory nodes rather than non\u2010specific antioxidant effects, consistent with a\n                    <jats:italic>system pharmacology<\/jats:italic>\n                    mode of action.\n                  <\/jats:p>","DOI":"10.1111\/bph.70557","type":"journal-article","created":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T13:32:42Z","timestamp":1783431162000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Re\u2010thinking peripheral dysfunctions in obesity: The emerging role of sulphaceutics and sulphanutraceutics"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9643-7378","authenticated-orcid":false,"given":"Martina","family":"Smimmo","sequence":"first","affiliation":[{"name":"Department of Pharmacy School of Medicine and Surgery  Naples 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