{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T03:28:06Z","timestamp":1790479686311,"version":"4.1.0"},"reference-count":31,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T00:00:00Z","timestamp":1784678400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"\n Background and Purpose<\/jats:title>\n \n Hyperuricaemia, a severe metabolic disorder linked to gout, is increasingly prevalent worldwide.\n Radix astragali<\/jats:italic>\n , as a drug\u2010food homologous material, has significantly expanded the market for novel functional foods. The solid\u2010state fermentation products of\n R.\u00a0astragali<\/jats:italic>\n and\n Paecilomyces cicadae<\/jats:italic>\n (RPF) promise to be candidates for lowering uric acid. Here, we have investigated the effects of RPF, using a model of hyperuricaemia in rats.\n <\/jats:p>\n <\/jats:sec>\n \n Experimental Approach<\/jats:title>\n \n Hyperuricaemia, and damage to liver and kidney, was induced in male Sprague\u2010Dawley rats receiving a high purine diet. Gut microbiota and short\u2010chain fatty acid metabolism were examined by multi\u2010omics analysis of rat faeces. Faecal microbiota transplantation was used to assess the therapeutic potential of gut microbiota and RPF. Effects of\n Eubacterium siraeum<\/jats:italic>\n on uric acid and short\u2010chain fatty acid metabolism were examined, in vitro and in hyperuricaemic rats.\n <\/jats:p>\n <\/jats:sec>\n \n Key Results<\/jats:title>\n \n RPF regulated dysbiosis of gut microbiota and restored the relative abundance of\n Ruminococcus<\/jats:italic>\n and\n Eubacterium<\/jats:italic>\n , which was associated with normalisation of serum levels of uric acid and short chain fatty acids. In vitro, the\n E. siraeum<\/jats:italic>\n DSM15702 strain extensively degraded uric acid. In vivo data from probiotic\u2010treated, hyperuricaemic rats, indicated a reduction of circulating uric acid levels.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusion and Implications<\/jats:title>\n \n Our study suggests that the gut microbiota\u2013short chain fatty acid axis may play a crucial role in maintaining intestinal homeostasis and in modulating the excretion of uric acid.\n E.\u00a0siraeum<\/jats:italic>\n may serve as a potential adjunct therapy for management of hyperuricaemia.\n <\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/bph.70565","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T13:55:43Z","timestamp":1784728543000},"page":"6081-6093","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Paecilomyces cicadae<\/i>\n \u2010fermented\n Radix astragali<\/i>\n modulates short\u2010chain fatty acids metabolism in the intestine through gut microbiota and ameliorates hyperuricaemia"],"prefix":"10.1111","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0000-3378","authenticated-orcid":false,"given":"Hong","family":"Wang","sequence":"first","affiliation":[{"name":"School of Traditional Chinese Medicine Shandong Medical and Pharmaceutical University Yantai China"},{"name":"College of Life Sciences Shandong Agricultural University Taian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Xu","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shandong University of Traditional Chinese Medicine Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kexin","family":"Liang","sequence":"additional","affiliation":[{"name":"School of Pharmacy Shandong University of Traditional Chinese Medicine Jinan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Tian","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Shandong Medical and Pharmaceutical University Yantai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhifeng","family":"Cui","sequence":"additional","affiliation":[{"name":"Binzhou Hospital of Traditional Chinese Medicine Binzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiayu","family":"Zhang","sequence":"additional","affiliation":[{"name":"School of Traditional Chinese Medicine Shandong Medical and Pharmaceutical University Yantai 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