{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T05:31:44Z","timestamp":1788931904301,"version":"build-2803163510"},"reference-count":91,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,12]],"date-time":"2026-07-12T00:00:00Z","timestamp":1783814400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Vetenskapsr\u00e5det","doi-asserted-by":"publisher","award":["2024\u201003125"],"award-info":[{"award-number":["2024\u201003125"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006313","name":"Barncancerfonden","doi-asserted-by":"publisher","award":["PR2024\u20100091"],"award-info":[{"award-number":["PR2024\u20100091"]}],"id":[{"id":"10.13039\/501100006313","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003792","name":"Hj\u00e4rnfonden","doi-asserted-by":"publisher","award":["FO2024\u20100275"],"award-info":[{"award-number":["FO2024\u20100275"]}],"id":[{"id":"10.13039\/501100003792","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004063","name":"Knut och Alice Wallenbergs Stiftelse","doi-asserted-by":"publisher","award":["2023.0534"],"award-info":[{"award-number":["2023.0534"]}],"id":[{"id":"10.13039\/501100004063","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002794","name":"Cancerfonden","doi-asserted-by":"publisher","award":["23 3098 Pj"],"award-info":[{"award-number":["23 3098 Pj"]}],"id":[{"id":"10.13039\/501100002794","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>CD93 is a single\u2010pass transmembrane glycoprotein that belongs to the C\u2010type lectin domain group XIV family of proteins. Although it is known to be expressed in other cell types, namely, in some subsets of immune cells, CD93 is primarily expressed on endothelial cells, where it acts as a crucial regulator of angiogenesis. CD93 interacts with a variety of ligands and signalling partners, which activates complex downstream signalling pathways that enable it to regulate dynamic processes such as endothelial cell migration and adhesion. Interestingly, CD93 is known to be up\u2010regulated in several pathologies, such as inflammatory conditions and different types of cancers, making it an attractive novel therapeutic target. In the present work, we review and summarize the existing literature on CD93's structure and signalling, involvement and contribution to prognosis in cancer, as well as current efforts in targeting this protein for disease treatment. With this, we underscore the importance of CD93 as a promising therapeutic target for future cancer therapies and provide insights into the present need for translation efforts and future directions.<\/jats:p>","DOI":"10.1111\/bph.70577","type":"journal-article","created":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:35:37Z","timestamp":1783920937000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["CD93\u2014An emerging vascular target in cancer therapy"],"prefix":"10.1111","author":[{"given":"Beatriz","family":"de Alves Pereira","sequence":"first","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, The Rudbeck Laboratory Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefano","family":"Barbera","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, The Rudbeck Laboratory Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roberta","family":"Lugano","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, The Rudbeck Laboratory Uppsala University  Uppsala Sweden"},{"name":"Candiolo Cancer Institute, FPO\u2010IRCCS  Candiolo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Dimberg","sequence":"additional","affiliation":[{"name":"Department of Immunology, Genetics and Pathology, The Rudbeck Laboratory Uppsala University  Uppsala Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,12]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70234"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70233"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2016.05.146"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12864-022-08659-6"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2021.05.006"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12964-019-0375-x"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms222212417"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2022.10.136"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.adw2206"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc3246"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.175.2.1239"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-014-1843-7"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm0603-653"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10144"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molmed.2020.11.006"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1002\/path.4072"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-023-10544-8"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.7136"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.matbio.2017.08.003"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00011-009-0064-0"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.1100803"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/imm.12974"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2024.113558"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0021-9258(18)54929-2"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.18552"},{"key":"e_1_2_8_27_1","doi-asserted-by":"publisher","DOI":"10.1158\/2159-8290.CD-21-1059"},{"key":"e_1_2_8_28_1","doi-asserted-by":"publisher","DOI":"10.1242\/jcs.018093"},{"key":"e_1_2_8_29_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.01078"},{"key":"e_1_2_8_30_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2024024063"},{"key":"e_1_2_8_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.immuni.2021.03.018"},{"key":"e_1_2_8_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.stem.2015.08.008"},{"key":"e_1_2_8_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2022.113361"},{"key":"e_1_2_8_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2024-010148"},{"key":"e_1_2_8_35_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1158360"},{"key":"e_1_2_8_36_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0051647"},{"key":"e_1_2_8_37_1","doi-asserted-by":"publisher","DOI":"10.1111\/febs.14985"},{"key":"e_1_2_8_38_1","doi-asserted-by":"publisher","DOI":"10.1038\/onc.2017.214"},{"key":"e_1_2_8_39_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41375-019-0684-5"},{"key":"e_1_2_8_40_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0900604106"},{"key":"e_1_2_8_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-31408-3"},{"key":"e_1_2_8_42_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-14-3636"},{"key":"e_1_2_8_43_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9051394"},{"key":"e_1_2_8_44_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v11.i4.738"},{"key":"e_1_2_8_45_1","doi-asserted-by":"publisher","DOI":"10.1002\/jbt.23688"},{"key":"e_1_2_8_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-019-03351-7"},{"key":"e_1_2_8_47_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.202201623RR"},{"key":"e_1_2_8_48_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI97459"},{"key":"e_1_2_8_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12031-022-02060-4"},{"key":"e_1_2_8_50_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2796.2011.02364.x"},{"key":"e_1_2_8_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2013.06.004"},{"key":"e_1_2_8_52_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.168.10.5222"},{"key":"e_1_2_8_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jim.2016.10.003"},{"key":"e_1_2_8_54_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.162.6.3583"},{"key":"e_1_2_8_55_1","doi-asserted-by":"publisher","DOI":"10.4049\/jimmunol.172.6.3406"},{"key":"e_1_2_8_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00384-015-2247-1"},{"key":"e_1_2_8_57_1","doi-asserted-by":"publisher","DOI":"10.1080\/14728222.2025.2500427"},{"issue":"9","key":"e_1_2_8_58_1","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.18632\/oncotarget.1887","article-title":"The characterization of a novel monoclonal antibody against CD93 unveils a new antiangiogenic target","volume":"5","author":"Orlandini M.","year":"2014","journal-title":"Oncotarget"},{"key":"e_1_2_8_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(00)80068-0"},{"key":"e_1_2_8_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2024.122422"},{"key":"e_1_2_8_61_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijbiomac.2025.143118"},{"key":"e_1_2_8_62_1","doi-asserted-by":"publisher","DOI":"10.1158\/2643-3230.BCD-20-0208"},{"key":"e_1_2_8_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2015.08.005"},{"key":"e_1_2_8_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.108663"},{"key":"e_1_2_8_65_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-014-1856-2"},{"key":"e_1_2_8_66_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.1200941"},{"key":"e_1_2_8_67_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-024-05874-4"},{"key":"e_1_2_8_68_1","doi-asserted-by":"publisher","DOI":"10.4168\/aair.2016.8.5.461"},{"key":"e_1_2_8_69_1","doi-asserted-by":"publisher","DOI":"10.1093\/cvr\/cvq086"},{"key":"e_1_2_8_70_1","doi-asserted-by":"publisher","DOI":"10.1080\/21688370.2016.1154641"},{"key":"e_1_2_8_71_1","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.71.1.133"},{"key":"e_1_2_8_72_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.abc8922"},{"key":"e_1_2_8_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2025.07.042"},{"key":"e_1_2_8_74_1","doi-asserted-by":"publisher","DOI":"10.1136\/jitc-2024-010554"},{"key":"e_1_2_8_75_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmolb.2021.793445"},{"key":"e_1_2_8_76_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.25689"},{"key":"e_1_2_8_77_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12131778"},{"key":"e_1_2_8_78_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci.insight.169830"},{"key":"e_1_2_8_79_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2007.04.021"},{"key":"e_1_2_8_80_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ceb.2011.10.002"},{"key":"e_1_2_8_81_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-018-36319-x"},{"key":"e_1_2_8_82_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-025-22816-3"},{"key":"e_1_2_8_83_1","doi-asserted-by":"publisher","DOI":"10.1083\/jcb.132.1.227"},{"key":"e_1_2_8_84_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2023.984816"},{"key":"e_1_2_8_85_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.str.2023.12.011"},{"key":"e_1_2_8_86_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2012.11020.x"},{"key":"e_1_2_8_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-025-03643-2"},{"key":"e_1_2_8_88_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1742-4658.2005.05031.x"},{"key":"e_1_2_8_89_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.89144"},{"key":"e_1_2_8_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2567.2005.02120.x"},{"key":"e_1_2_8_91_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2022.817965"},{"key":"e_1_2_8_92_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.compbiomed.2022.105727"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70577","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.70577","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70577","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T05:35:39Z","timestamp":1783920939000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.70577"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,12]]},"references-count":91,"alternative-id":["10.1111\/bph.70577"],"URL":"https:\/\/doi.org\/10.1111\/bph.70577","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,12]]},"assertion":[{"value":"2026-01-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"bph.70577"}}