{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:22:28Z","timestamp":1788340948937,"version":"build-2803163510"},"reference-count":58,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102020\u2010NR054081"],"award-info":[{"award-number":["RS\u20102020\u2010NR054081"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102023\u2010NR077056"],"award-info":[{"award-number":["RS\u20102023\u2010NR077056"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102024\u201000335573"],"award-info":[{"award-number":["RS\u20102024\u201000335573"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["RS\u20102025\u201002353061"],"award-info":[{"award-number":["RS\u20102025\u201002353061"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>Aspergillus fumigatus<\/jats:italic>\n                      <\/jats:styled-content>\n                      (\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>A. fumigatus<\/jats:italic>\n                      <\/jats:styled-content>\n                      ) exposure causes of severe allergic asthma, characterized by airway inflammation and epithelial dysfunction. TMBIM6 (Bax inhibitor\u20101) has been implicated in airway epithelial stress responses and AKT signalling. This study aimed to elucidate the therapeutic potential of the drug called the Bax inhibitor\u20101 antagonist (BIA) and its structural analogues in a murine model of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>A. fumigatus<\/jats:italic>\n                      <\/jats:styled-content>\n                      \u2010induced allergic asthma.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>\n                      19 BIA analogues were synthesized and evaluated alongside the original drug BIA in a murine model of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>A. fumigatus<\/jats:italic>\n                      <\/jats:styled-content>\n                      \u2010induced airway inflammation. Inflammatory phenotypes were assessed by analysing bronchoalveolar lavage fluid (BALF), lung histopathology, quantification of T\u2010helper 2 (Th2) and Th17 cytokines. Mechanistic investigations evaluated the AKT\/NLRP3 pathway and epithelial\u2010derived cytokines, while TMBIM6\u2010mediated ER Ca\n                      <jats:sup>2+<\/jats:sup>\n                      flux was monitored using a TMBIM6\u2010GCaMP3 reporter system.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      BIA and its analogues significantly attenuated inflammatory cell infiltration, goblet cell hyperplasia, airway remodelling and Th2\u2010associated cytokine expression in the lungs of\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>A. fumigatus<\/jats:italic>\n                      <\/jats:styled-content>\n                      \u2010challenged mice. BIA and selected analogues also suppressed Th17\u2010associated cytokine expression. Moreover, BIA analogues preferentially reduced epithelial\u2010derived cytokine expression. Mechanistically, BIA and select analogues markedly suppressed AKT phosphorylation and NLRP3 expression in lungs and airway epithelial cells. Pharmacological inhibition and TMBIM6 knockdown supported the involvement of the TMBIM6\/AKT\/NLRP3 signalling axis, while BIA and select analogues inhibited TMBIM6\u2010mediated ER calcium leakage.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications<\/jats:title>\n                    <jats:p>\n                      BIA and its analogues attenuate\n                      <jats:styled-content style=\"fixed-case\">\n                        <jats:italic>A. fumigatus<\/jats:italic>\n                      <\/jats:styled-content>\n                      \u2010induced allergic lung inflammation by targeting the TMBIM6\/calcium\/AKT axis, suppressing NLRP3 signalling and epithelial\u2010derived inflammatory cytokines. These findings highlight this axis as a promising therapeutic target for fungal\u2010associated airway inflammation.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70579","type":"journal-article","created":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T11:46:19Z","timestamp":1784202379000},"page":"5975-5991","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic potential of a Bax inhibitor\u20101\/TMBIM6 antagonist (BIA) and its analogues in\n                    <i>Aspergillus fumigatus<\/i>\n                    \u2010induced asthma via dual targeting of AKT and epithelial\u2010derived inflammatory cytokines"],"prefix":"10.1111","volume":"183","author":[{"given":"Young\u2010Jin","family":"Yu","sequence":"first","affiliation":[{"name":"School of Pharmacy Jeonbuk National University  Jeonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahsan","family":"Ullah","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jeonbuk National University  Jeonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jisun","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jeonbuk National University  Jeonju South Korea"},{"name":"Institute of New Drug Development Jeonbuk National University  Jeonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1148-2944","authenticated-orcid":false,"given":"Mehedi Hasan","family":"Bappi","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jeonbuk National University  Jeonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yerim","family":"Heo","sequence":"additional","affiliation":[{"name":"Department of Chemistry Gwangju Institute of Science and Technology  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Hee","family":"Ahn","sequence":"additional","affiliation":[{"name":"Department of Chemistry Gwangju Institute of Science and Technology  Gwangju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1479-9824","authenticated-orcid":false,"given":"Hyun\u2010Kyoung","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jeonbuk National University  Jeonju South Korea"},{"name":"Institute of New Drug Development Jeonbuk National University  Jeonju South Korea"},{"name":"Respiratory Drug Development Research Institute Jeonbuk National University Medical School  Jeonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han\u2010Jung","family":"Chae","sequence":"additional","affiliation":[{"name":"School of Pharmacy Jeonbuk National University  Jeonju South Korea"},{"name":"Institute of New Drug Development Jeonbuk National University  Jeonju South Korea"},{"name":"Respiratory Drug Development Research Institute Jeonbuk National University Medical School  Jeonju South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,16]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2025.2526384"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2023.08.004"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/ijmr.IJMR_1187_19"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16181"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.14112"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20061675"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pccm.2024.11.005"},{"key":"e_1_2_14_9_1","doi-asserted-by":"publisher","DOI":"10.1093\/jac\/dkt508"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2018.06.015"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1398-9995.2011.02586.x"},{"key":"e_1_2_14_12_1","doi-asserted-by":"publisher","DOI":"10.1183\/16000617.0137-2017"},{"key":"e_1_2_14_13_1","first-page":"3274","volume-title":"Fungal\u2010Driven Airways Dis\u2010Immunity From Asthma to Allergic Bronchopulmonary Aspergillosis: Dissecting Similarities and Differences","author":"Caminati M.","year":"2025"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2016.02.033"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.939127"},{"key":"e_1_2_14_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2022\/9444227"},{"key":"e_1_2_14_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.17441"},{"key":"e_1_2_14_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.691559"},{"key":"e_1_2_14_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.alit.2023.07.003"},{"key":"e_1_2_14_20_1","doi-asserted-by":"publisher","DOI":"10.1128\/mbio.01239-22"},{"key":"e_1_2_14_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1074-7613(01)00243-6"},{"key":"e_1_2_14_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/all.15609"},{"key":"e_1_2_14_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40001-023-01630-5"},{"key":"e_1_2_14_24_1","doi-asserted-by":"publisher","DOI":"10.3390\/biomedicines12102312"},{"key":"e_1_2_14_25_1","doi-asserted-by":"publisher","DOI":"10.1099\/mic.0.2007\/007641-0"},{"key":"e_1_2_14_26_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-0031-1295716"},{"key":"e_1_2_14_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2017.00134"},{"key":"e_1_2_14_28_1","doi-asserted-by":"publisher","DOI":"10.2332\/allergolint.09-OA-0118"},{"key":"e_1_2_14_29_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2017-210326"},{"key":"e_1_2_14_30_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-17802-4"},{"key":"e_1_2_14_31_1","doi-asserted-by":"publisher","DOI":"10.1038\/emm.2017.270"},{"key":"e_1_2_14_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/15548627.2020.1732161"},{"key":"e_1_2_14_33_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/843763"},{"key":"e_1_2_14_34_1","doi-asserted-by":"publisher","DOI":"10.1165\/rcmb.2012-0444OC"},{"key":"e_1_2_14_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2012.02.007"},{"key":"e_1_2_14_36_1","doi-asserted-by":"publisher","DOI":"10.1136\/thoraxjnl-2015-207096"},{"key":"e_1_2_14_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaci.2006.04.041"},{"key":"e_1_2_14_38_1","doi-asserted-by":"publisher","DOI":"10.1111\/BPH.15178"},{"key":"e_1_2_14_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0169-409X(00)00129-0"},{"key":"e_1_2_14_40_1","doi-asserted-by":"publisher","DOI":"10.1080\/13693780500052255"},{"key":"e_1_2_14_41_1","doi-asserted-by":"publisher","DOI":"10.3390\/jof9040450"},{"key":"e_1_2_14_42_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00508-10"},{"key":"e_1_2_14_43_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20030298"},{"key":"e_1_2_14_44_1","doi-asserted-by":"publisher","DOI":"10.1111\/nyas.12059"},{"key":"e_1_2_14_45_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2735"},{"key":"e_1_2_14_46_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_14_47_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cytogfr.2010.10.002"},{"key":"e_1_2_14_48_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-065X.2008.00713.x"},{"key":"e_1_2_14_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2021.107847"},{"key":"e_1_2_14_50_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells12040591"},{"key":"e_1_2_14_51_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajplung.00341.2001"},{"key":"e_1_2_14_52_1","doi-asserted-by":"publisher","DOI":"10.1080\/14756360701425014"},{"key":"e_1_2_14_53_1","doi-asserted-by":"publisher","DOI":"10.1128\/IAI.00359-15"},{"key":"e_1_2_14_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.intimp.2021.108489"},{"key":"e_1_2_14_55_1","doi-asserted-by":"publisher","DOI":"10.1080\/02770903.2021.1942039"},{"key":"e_1_2_14_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ddmec.2012.09.003"},{"key":"e_1_2_14_57_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2024.1478624"},{"key":"e_1_2_14_58_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40364-023-00474-9"},{"key":"e_1_2_14_59_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10957"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70579","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.70579","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70579","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:59:19Z","timestamp":1788339559000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.70579"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,16]]},"references-count":58,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/bph.70579"],"URL":"https:\/\/doi.org\/10.1111\/bph.70579","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,16]]},"assertion":[{"value":"2025-12-03","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-15","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-16","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}