{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T09:22:32Z","timestamp":1788340952157,"version":"build-2803163510"},"reference-count":368,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T00:00:00Z","timestamp":1785801600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>\n                    Antipsychotic drugs targeting dopamine receptors have been used to treat schizophrenia for decades, primarily alleviating positive symptoms such as hallucinations and delusions. However, they provide limited benefit for cognitive and negative symptoms\u2014major contributors to poor outcomes\u2014and are frequently associated with significant side effects. The recent approval of KarXT, the first muscarinic\u2010targeting antipsychotic drug, marks a potentially important shift in therapeutic strategy. Here, we review the mechanism of action of xanomeline\u00a0(the centrally active component of KarXT) and related compounds, using a RDoC\u2010informed framework spanning receptor, cellular, systems, network and behavioural level. We interrogate the pharmacological profile of xanomeline at M\n                    <jats:sub>1<\/jats:sub>\n                    \u2013M\n                    <jats:sub>5<\/jats:sub>\n                    receptors, highlighting the role of receptor reserve in conferring partial agonist activity at M\n                    <jats:sub>1<\/jats:sub>\n                    and M\n                    <jats:sub>4<\/jats:sub>\n                    receptors in vivo. At a systems level, xanomeline is likely to act at M\n                    <jats:sub>1<\/jats:sub>\n                    \/M\n                    <jats:sub>4<\/jats:sub>\n                    receptors on glutamatergic afferents and cortical pyramidal neurons; M\n                    <jats:sub>2<\/jats:sub>\n                    receptors in the thalamic reticular nucleus; M\n                    <jats:sub>4<\/jats:sub>\n                    receptors in the striatum, on glutamatergic afferents and GABAergic direct pathway medium spiny neurons; and M\n                    <jats:sub>5<\/jats:sub>\n                    receptors on dopaminergic afferents in the striatum. We consider mechanistic overlap with clozapine, and the evidence that 5\u2010HT\n                    <jats:sub>1A<\/jats:sub>\n                    receptor partial agonist actions and 5\u2010HT\n                    <jats:sub>7<\/jats:sub>\n                    receptor modulation may contribute to xanomeline's broader profile. We propose that combining muscarinic actions with activity at 5\u2010HT receptors may enhance efficacy by restoring disrupted circuits and networks relevant to the full spectrum of symptoms, while reducing dopamine\u2010mediated and metabolic side effects. In conclusion, muscarinic modulation is a promising direction not only for schizophrenia but potentially trans\u2010diagnostically in psychiatry.\n                  <\/jats:p>","DOI":"10.1111\/bph.70582","type":"journal-article","created":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T00:41:37Z","timestamp":1785890497000},"page":"5701-5731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Muscarinic agonists for schizophrenia: Bridging preclinical evidence and clinical enthusiasm"],"prefix":"10.1111","volume":"183","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4439-0795","authenticated-orcid":false,"given":"Brian J.","family":"Morris","sequence":"first","affiliation":[{"name":"College of Medical Veterinary and Life Sciences, School of Psychology and Neuroscience University of Glasgow  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7371-8465","authenticated-orcid":false,"given":"Judith A.","family":"Pratt","sequence":"additional","affiliation":[{"name":"Strathclyde Institute of Pharmacy and Biomedical Sciences University of Strathclyde  Glasgow UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,4]]},"reference":[{"key":"e_1_2_16_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-009-1521-8"},{"key":"e_1_2_16_3_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0706780"},{"key":"e_1_2_16_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000139437"},{"key":"e_1_2_16_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2022.05.005"},{"key":"e_1_2_16_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroimage.2024.120686"},{"key":"e_1_2_16_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70230"},{"key":"e_1_2_16_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70234"},{"key":"e_1_2_16_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70231"},{"key":"e_1_2_16_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-019-04860-1"},{"key":"e_1_2_16_11_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.115.226910"},{"key":"e_1_2_16_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/nn992"},{"key":"e_1_2_16_13_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0122722"},{"key":"e_1_2_16_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.13169"},{"key":"e_1_2_16_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4530(94)00084-n"},{"key":"e_1_2_16_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2005.05.005"},{"key":"e_1_2_16_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2021.03.028"},{"key":"e_1_2_16_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psychres.2008.06.006"},{"key":"e_1_2_16_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/7854_2015_376"},{"key":"e_1_2_16_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-031-26441-2"},{"key":"e_1_2_16_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0024-3205(00)00661-5"},{"key":"e_1_2_16_22_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.08.023"},{"key":"e_1_2_16_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.162371899"},{"key":"e_1_2_16_24_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.79418"},{"key":"e_1_2_16_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2025.107690"},{"key":"e_1_2_16_26_1","doi-asserted-by":"publisher","DOI":"10.1113\/jphysiol.2014.277376"},{"key":"e_1_2_16_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(88)90123-2"},{"key":"e_1_2_16_28_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.18-23-10207.1998"},{"key":"e_1_2_16_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)09528-X"},{"issue":"4","key":"e_1_2_16_30_1","first-page":"S16","article-title":"The selective muscarinic agonist xanomeline improves both the cognitive deficits and behavioral symptoms of Alzheimer disease","volume":"11","author":"Bodick N. C.","year":"1997","journal-title":"Alzheimer Disease and Associated Disorders"},{"key":"e_1_2_16_31_1","doi-asserted-by":"publisher","DOI":"10.1017\/s146114571000009x"},{"key":"e_1_2_16_32_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/4.1.69"},{"key":"e_1_2_16_33_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.166.1.68"},{"key":"e_1_2_16_34_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2017015"},{"key":"e_1_2_16_35_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2017015"},{"key":"e_1_2_16_36_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm00012a019"},{"key":"e_1_2_16_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9861(19990802)410:3<431::AID-CNE6>3.0.CO;2-R"},{"key":"e_1_2_16_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107536"},{"key":"e_1_2_16_39_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn500128b"},{"key":"e_1_2_16_40_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.08-12-04646.1988"},{"key":"e_1_2_16_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-023-41199-5"},{"key":"e_1_2_16_42_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.092155"},{"key":"e_1_2_16_43_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.4c00293"},{"key":"e_1_2_16_44_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1098-2299(199702)40:2<>3.0.CO;2-K"},{"key":"e_1_2_16_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)38668-4"},{"key":"e_1_2_16_46_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.2"},{"key":"e_1_2_16_47_1","doi-asserted-by":"publisher","DOI":"10.3390\/ph15030337"},{"key":"e_1_2_16_48_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aan8868"},{"key":"e_1_2_16_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0031-6997(24)01362-0"},{"key":"e_1_2_16_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(92)90660-2"},{"key":"e_1_2_16_51_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10571-019-00752-x"},{"key":"e_1_2_16_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainres.2004.07.009"},{"key":"e_1_2_16_53_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130100682"},{"key":"e_1_2_16_54_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0028-3908(02)00091-6"},{"key":"e_1_2_16_55_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300031"},{"key":"e_1_2_16_56_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1423-0"},{"key":"e_1_2_16_57_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20240556"},{"key":"e_1_2_16_58_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pneurobio.2010.06.007"},{"key":"e_1_2_16_59_1","first-page":"17","volume-title":"Safety and efficacy of KarXT (xanomeline\u2010trospium) in patients with schizophrenia: Results from a phase 3, randomized, double\u2010blind, placebo\u2010controlled trial (EMERGENT\u20102)","author":"Correll C. U.","year":"2022"},{"key":"e_1_2_16_60_1","doi-asserted-by":"publisher","DOI":"10.1016\/0006-8993(86)90448-8"},{"key":"e_1_2_16_61_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.271.8.3963"},{"key":"e_1_2_16_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)00918-5"},{"key":"e_1_2_16_63_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(97)00649-5"},{"key":"e_1_2_16_64_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(93)90483-2"},{"key":"e_1_2_16_65_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.156.4.610"},{"key":"e_1_2_16_66_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-2017-1"},{"key":"e_1_2_16_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2210-9-14"},{"key":"e_1_2_16_68_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.7b00597"},{"key":"e_1_2_16_69_1","doi-asserted-by":"publisher","DOI":"10.1038\/tp.2015.60"},{"key":"e_1_2_16_70_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhs322"},{"key":"e_1_2_16_71_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajmg.b.20129"},{"key":"e_1_2_16_72_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2024.107510"},{"key":"e_1_2_16_73_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4000684"},{"key":"e_1_2_16_74_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.mp.4001199"},{"key":"e_1_2_16_75_1","doi-asserted-by":"publisher","DOI":"10.1021\/acs.jmedchem.9b02100"},{"key":"e_1_2_16_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0149-2918(04)90066-5"},{"key":"e_1_2_16_77_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881111421974"},{"key":"e_1_2_16_78_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0370-11.2011"},{"key":"e_1_2_16_79_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhv227"},{"key":"e_1_2_16_80_1","doi-asserted-by":"publisher","DOI":"10.1111\/jnc.16243"},{"key":"e_1_2_16_81_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.2999-05.2005"},{"key":"e_1_2_16_82_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0337-12.2012"},{"key":"e_1_2_16_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2010.06.017"},{"key":"e_1_2_16_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/d41586-024-03123-9"},{"key":"e_1_2_16_85_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbx034"},{"key":"e_1_2_16_86_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)23208-6"},{"key":"e_1_2_16_87_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf00171078"},{"key":"e_1_2_16_88_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)29217-X"},{"key":"e_1_2_16_89_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.psc.2016.01.006"},{"key":"e_1_2_16_90_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0056-2"},{"key":"e_1_2_16_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2024.11.013"},{"key":"e_1_2_16_92_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2024.2890"},{"key":"e_1_2_16_93_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.1848-10.2010"},{"key":"e_1_2_16_94_1","first-page":"137","article-title":"Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990\u20132019: A systematic analysis for the global burden of disease study 2019","volume":"9","author":"Ferrari A. J.","year":"2019","journal-title":"Lancet Psychiatry"},{"key":"e_1_2_16_95_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.108.145219"},{"key":"e_1_2_16_96_1","doi-asserted-by":"publisher","DOI":"10.1002\/jnr.10728"},{"key":"e_1_2_16_97_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbu011"},{"key":"e_1_2_16_98_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1460-9568.2000.00250.x"},{"key":"e_1_2_16_99_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2022.05.009"},{"key":"e_1_2_16_100_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-med-092112-142937"},{"key":"e_1_2_16_101_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.267"},{"key":"e_1_2_16_102_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.21082"},{"key":"e_1_2_16_103_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.903030405"},{"key":"e_1_2_16_104_1","doi-asserted-by":"publisher","DOI":"10.1515\/revneuro.2008.19.4-5.227"},{"key":"e_1_2_16_105_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.261583798"},{"key":"e_1_2_16_106_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-neuro-061010-113641"},{"key":"e_1_2_16_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0893-133x(00)00087-7"},{"key":"e_1_2_16_108_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2015.189"},{"key":"e_1_2_16_109_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-020-0685-1"},{"key":"e_1_2_16_110_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2202-13-42"},{"key":"e_1_2_16_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2012.04.006"},{"key":"e_1_2_16_112_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cub.2017.05.010"},{"key":"e_1_2_16_113_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-642-23274-9_10"},{"key":"e_1_2_16_114_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.96.18.10483"},{"key":"e_1_2_16_115_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.5b00123"},{"key":"e_1_2_16_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.07.013"},{"key":"e_1_2_16_117_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2015.11.016"},{"key":"e_1_2_16_118_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2153-8"},{"key":"e_1_2_16_119_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.6b00230"},{"key":"e_1_2_16_120_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.105.090134"},{"key":"e_1_2_16_121_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0015722"},{"key":"e_1_2_16_122_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2004.09.009"},{"key":"e_1_2_16_123_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cellsig.2022.110416"},{"key":"e_1_2_16_124_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.1388-23.2023"},{"key":"e_1_2_16_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00552-G"},{"key":"e_1_2_16_126_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1996.tb15241.x"},{"key":"e_1_2_16_127_1","doi-asserted-by":"publisher","DOI":"10.31887\/DCNS.2016.18.1\/shaber"},{"key":"e_1_2_16_128_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.0271-06.2006"},{"key":"e_1_2_16_129_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-018-0281-8"},{"key":"e_1_2_16_130_1","doi-asserted-by":"publisher","DOI":"10.1002\/ar.21186"},{"key":"e_1_2_16_131_1","doi-asserted-by":"publisher","DOI":"10.1002\/hipo.20249"},{"key":"e_1_2_16_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.12.044"},{"key":"e_1_2_16_133_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.14-05-03351.1994"},{"key":"e_1_2_16_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-019-1506-7"},{"key":"e_1_2_16_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.04.007"},{"key":"e_1_2_16_136_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20240076"},{"key":"e_1_2_16_137_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2024.08.001"},{"key":"e_1_2_16_138_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2020.03.012"},{"key":"e_1_2_16_139_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbp006"},{"key":"e_1_2_16_140_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41593-019-0564-3"},{"key":"e_1_2_16_141_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhp161"},{"key":"e_1_2_16_142_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-018-4972-y"},{"key":"e_1_2_16_143_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2007.05.007"},{"key":"e_1_2_16_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(19)31135-3"},{"key":"e_1_2_16_145_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-020-05496-x"},{"key":"e_1_2_16_146_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.1615-19.2019"},{"key":"e_1_2_16_147_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-8993(02)03692-2"},{"key":"e_1_2_16_148_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0893-133x(01)00312-8"},{"key":"e_1_2_16_149_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1098-2396(199712)27:4<357::Aid-syn9>3.0.Co;2-b"},{"key":"e_1_2_16_150_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1990.tb14091.x"},{"key":"e_1_2_16_151_1","doi-asserted-by":"publisher","DOI":"10.1002\/alz.13090"},{"key":"e_1_2_16_152_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.301.3.1033"},{"key":"e_1_2_16_153_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140-6736(21)01730-x"},{"key":"e_1_2_16_154_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.20241187"},{"key":"e_1_2_16_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.11.015"},{"key":"e_1_2_16_156_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.1850-08.2008"},{"key":"e_1_2_16_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbr.2020.112649"},{"key":"e_1_2_16_158_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.078741"},{"key":"e_1_2_16_159_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.1988.01800330013001"},{"key":"e_1_2_16_160_1","volume-title":"Handbook of ayurvedic medicinal plants","author":"Kapoor L. D.","year":"1990"},{"key":"e_1_2_16_161_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.160.1.13"},{"key":"e_1_2_16_162_1","doi-asserted-by":"publisher","DOI":"10.1006\/phrs.1999.0453"},{"key":"e_1_2_16_163_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1904338118"},{"key":"e_1_2_16_164_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2025.12.015"},{"issue":"1","key":"e_1_2_16_165_1","article-title":"Safety and tolerability of xanomeline and trospium chloride in schizophrenia: pooled results from the 5\u2010week, randomized, double\u2010blind, placebo\u2010controlled EMERGENT trials","volume":"86","author":"Kaul I.","year":"2025","journal-title":"Journal of Clinical Psychiatry"},{"key":"e_1_2_16_166_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2024.0785"},{"key":"e_1_2_16_167_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.81863"},{"key":"e_1_2_16_168_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0611417104"},{"key":"e_1_2_16_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2024.105989"},{"key":"e_1_2_16_170_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuint.2019.03.015"},{"key":"e_1_2_16_171_1","doi-asserted-by":"publisher","DOI":"10.1159\/000072883"},{"key":"e_1_2_16_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eurpsy.2004.12.007"},{"key":"e_1_2_16_173_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2016.11.024"},{"key":"e_1_2_16_174_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00406-018-0869-3"},{"key":"e_1_2_16_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0704588"},{"key":"e_1_2_16_176_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd4295"},{"key":"e_1_2_16_177_1","unstructured":"Krystal J. Kane J. &Correll C.(n.d.)CVL\u2010231 as a novel positive allosteric modulator targeting M4 muscarinic receptors: Results from a phase 1b trial in patients with schizophrenia. Presented at: 2022 Hybrid Congress of the Schizophrenia International Research Society; April 6 2022; Florence Italy. In."},{"key":"e_1_2_16_178_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)38019-X"},{"key":"e_1_2_16_179_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2010.08.013"},{"key":"e_1_2_16_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)90017-5"},{"key":"e_1_2_16_181_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.15-05-04077.1995"},{"key":"e_1_2_16_182_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.11-10-03218.1991"},{"key":"e_1_2_16_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-025-03633-8"},{"key":"e_1_2_16_184_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2007.06.025"},{"key":"e_1_2_16_185_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.04.028"},{"key":"e_1_2_16_186_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.08.009"},{"key":"e_1_2_16_187_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuron.2005.05.002"},{"key":"e_1_2_16_188_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2569-9"},{"key":"e_1_2_16_189_1","doi-asserted-by":"publisher","DOI":"10.1093\/cercor\/bhr220"},{"key":"e_1_2_16_190_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf00567121"},{"key":"e_1_2_16_191_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.170.1.18"},{"key":"e_1_2_16_192_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2013.10.013"},{"key":"e_1_2_16_193_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2017.03.017"},{"key":"e_1_2_16_194_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.1998.79.1.474"},{"key":"e_1_2_16_195_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.107.122093"},{"key":"e_1_2_16_196_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2004.05.033"},{"key":"e_1_2_16_197_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2019.07.003"},{"key":"e_1_2_16_198_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.95.19.11465"},{"key":"e_1_2_16_199_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.902780209"},{"key":"e_1_2_16_200_1","doi-asserted-by":"publisher","DOI":"10.1038\/319402a0"},{"key":"e_1_2_16_201_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbx180"},{"key":"e_1_2_16_202_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.08.032"},{"key":"e_1_2_16_203_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41537-017-0032-6"},{"key":"e_1_2_16_204_1","doi-asserted-by":"publisher","DOI":"10.18553\/jmcp.2024.30.6.624"},{"key":"e_1_2_16_205_1","doi-asserted-by":"publisher","DOI":"10.1097\/yco.0000000000000244"},{"key":"e_1_2_16_206_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1000751107"},{"key":"e_1_2_16_207_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tics.2011.08.003"},{"key":"e_1_2_16_208_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2022.09.029"},{"key":"e_1_2_16_209_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00429-010-0262-0"},{"key":"e_1_2_16_210_1","doi-asserted-by":"publisher","DOI":"10.1021\/jm960467d"},{"key":"e_1_2_16_211_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-979481"},{"key":"e_1_2_16_212_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-2999(99)00341-6"},{"key":"e_1_2_16_213_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euroneuro.2014.03.008"},{"key":"e_1_2_16_214_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-021-01188-y"},{"key":"e_1_2_16_215_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130000486"},{"key":"e_1_2_16_216_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0304445101"},{"key":"e_1_2_16_217_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)13426-5"},{"key":"e_1_2_16_218_1","doi-asserted-by":"publisher","DOI":"10.1111\/cge.12485"},{"key":"e_1_2_16_219_1","doi-asserted-by":"publisher","DOI":"10.1177\/02698811251319458"},{"key":"e_1_2_16_220_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.11.5194"},{"key":"e_1_2_16_221_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.23254"},{"key":"e_1_2_16_222_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2006.07.002"},{"key":"e_1_2_16_223_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphys.2022.974160"},{"key":"e_1_2_16_224_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2014.12.024"},{"key":"e_1_2_16_225_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300983"},{"key":"e_1_2_16_226_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnbeh.2014.00171"},{"key":"e_1_2_16_227_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.104.067140"},{"key":"e_1_2_16_228_1","doi-asserted-by":"publisher","DOI":"10.1016\/0028-3908(95)00170-0"},{"key":"e_1_2_16_229_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-2999(98)00483-x"},{"key":"e_1_2_16_230_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.89.10.4270"},{"key":"e_1_2_16_231_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11064-008-9886-3"},{"key":"e_1_2_16_232_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2012.04.046"},{"key":"e_1_2_16_233_1","doi-asserted-by":"publisher","DOI":"10.1002\/cne.24409"},{"key":"e_1_2_16_234_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881116658989"},{"key":"e_1_2_16_235_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1440-1681.2007.04595.x"},{"key":"e_1_2_16_236_1","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3940(90)90434-B"},{"key":"e_1_2_16_237_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2004.08.009"},{"key":"e_1_2_16_238_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0701357"},{"key":"e_1_2_16_239_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0893-133x(98)00048-7"},{"key":"e_1_2_16_240_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-021-02732-y"},{"key":"e_1_2_16_241_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11934-003-0023-1"},{"key":"e_1_2_16_242_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn500003z"},{"key":"e_1_2_16_243_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep34314"},{"key":"e_1_2_16_244_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)36626-1"},{"key":"e_1_2_16_245_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.2011.9.1.36"},{"key":"e_1_2_16_246_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2024.03.014"},{"key":"e_1_2_16_247_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-3223(00)01017-9"},{"key":"e_1_2_16_248_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnsys.2016.00104"},{"key":"e_1_2_16_249_1","doi-asserted-by":"publisher","DOI":"10.1002\/(sici)1096-9861(19990215)404:3<>3.0.co;2-y"},{"key":"e_1_2_16_250_1","doi-asserted-by":"publisher","DOI":"10.1176\/appi.ajp.159.2.227"},{"key":"e_1_2_16_251_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41589-022-01247-5"},{"key":"e_1_2_16_252_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881114565805"},{"key":"e_1_2_16_253_1","doi-asserted-by":"publisher","DOI":"10.1177\/02698811251375104"},{"key":"e_1_2_16_254_1","doi-asserted-by":"publisher","DOI":"10.1177\/02698811221104064"},{"key":"e_1_2_16_255_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrd3649"},{"key":"e_1_2_16_256_1","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12116"},{"key":"e_1_2_16_257_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-2057-6"},{"key":"e_1_2_16_258_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sbx078"},{"key":"e_1_2_16_259_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/sby076"},{"key":"e_1_2_16_260_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.1424-21.2022"},{"key":"e_1_2_16_261_1","doi-asserted-by":"publisher","DOI":"10.3389\/fpsyt.2021.631589"},{"key":"e_1_2_16_262_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)12790-0"},{"key":"e_1_2_16_263_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.1995.tb13339.x"},{"key":"e_1_2_16_264_1","doi-asserted-by":"publisher","DOI":"10.1177\/0269881107081521"},{"key":"e_1_2_16_265_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(92)90054-6"},{"key":"e_1_2_16_266_1","doi-asserted-by":"publisher","DOI":"10.1016\/0306-4522(94)00426-6"},{"key":"e_1_2_16_267_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(97)81951-6"},{"key":"e_1_2_16_268_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-018-5065-7"},{"key":"e_1_2_16_269_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)38596-4"},{"key":"e_1_2_16_270_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0304-3940(00)01011-9"},{"key":"e_1_2_16_271_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0024-3205(98)00594-3"},{"key":"e_1_2_16_272_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0024-3205(97)00044-1"},{"key":"e_1_2_16_273_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002109900170"},{"key":"e_1_2_16_274_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00335-023-10005-4"},{"key":"e_1_2_16_275_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf00177553"},{"key":"e_1_2_16_276_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.brainresbull.2008.09.016"},{"key":"e_1_2_16_277_1","doi-asserted-by":"publisher","DOI":"10.1093\/schbul\/17.2.247"},{"key":"e_1_2_16_278_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-9964(90)90004-q"},{"key":"e_1_2_16_279_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0703139"},{"key":"e_1_2_16_280_1","doi-asserted-by":"publisher","DOI":"10.1023\/A:1022486721267"},{"key":"e_1_2_16_281_1","doi-asserted-by":"publisher","DOI":"10.1007\/bf00238347"},{"key":"e_1_2_16_282_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.170202"},{"key":"e_1_2_16_283_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2005.06.038"},{"key":"e_1_2_16_284_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchemneu.2016.07.006"},{"key":"e_1_2_16_285_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2006.08.050"},{"key":"e_1_2_16_286_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-011-2225-4"},{"key":"e_1_2_16_287_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02245606"},{"key":"e_1_2_16_288_1","doi-asserted-by":"publisher","DOI":"10.1016\/0920-9964(95)00043-7"},{"key":"e_1_2_16_289_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.3581-04.2004"},{"key":"e_1_2_16_290_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1471-4159.2001.00308.x"},{"key":"e_1_2_16_291_1","doi-asserted-by":"publisher","DOI":"10.1159\/000440979"},{"key":"e_1_2_16_292_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(25)38667-2"},{"key":"e_1_2_16_293_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0920-9964(99)00138-3"},{"key":"e_1_2_16_294_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300203"},{"key":"e_1_2_16_295_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1508846112"},{"key":"e_1_2_16_296_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04556-w"},{"key":"e_1_2_16_297_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.bp.115.177261"},{"key":"e_1_2_16_298_1","doi-asserted-by":"publisher","DOI":"10.1007\/s43440-024-00674-6"},{"key":"e_1_2_16_299_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2014.2414"},{"key":"e_1_2_16_300_1","doi-asserted-by":"publisher","DOI":"10.9758\/cpn.24.1253"},{"key":"e_1_2_16_301_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-021-01089-0"},{"key":"e_1_2_16_302_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41582-023-00872-5"},{"key":"e_1_2_16_303_1","doi-asserted-by":"publisher","DOI":"10.1002\/j.1552-4604.1995.tb04123.x"},{"key":"e_1_2_16_304_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-3565(24)29291-0"},{"key":"e_1_2_16_305_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0027538"},{"key":"e_1_2_16_306_1","unstructured":"Steriade M. Jones E. G. &McCormick D. A. E.(1997).Thalamus: organisation and function 2(Oxford UK) 617\u2013651."},{"key":"e_1_2_16_307_1","doi-asserted-by":"publisher","DOI":"10.1038\/mp.2017.230"},{"key":"e_1_2_16_308_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2011.05.016"},{"key":"e_1_2_16_309_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1471-4159.2009.06193.x"},{"key":"e_1_2_16_310_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bmcl.2007.01.093"},{"key":"e_1_2_16_311_1","doi-asserted-by":"publisher","DOI":"10.1192\/bjp.177.2.174"},{"key":"e_1_2_16_312_1","doi-asserted-by":"publisher","DOI":"10.1176\/ajp.2007.164.4.670"},{"key":"e_1_2_16_313_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.3177-12.2013"},{"key":"e_1_2_16_314_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.07.020"},{"key":"e_1_2_16_315_1","doi-asserted-by":"publisher","DOI":"10.1002\/cpdd.1460"},{"key":"e_1_2_16_316_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2008.01.022"},{"key":"e_1_2_16_317_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2680.1999.00118.x"},{"key":"e_1_2_16_318_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-010-2001-x"},{"key":"e_1_2_16_319_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300039"},{"key":"e_1_2_16_320_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-009-1740-z"},{"key":"e_1_2_16_321_1","doi-asserted-by":"publisher","DOI":"10.1111\/gbb.12710"},{"key":"e_1_2_16_322_1","doi-asserted-by":"publisher","DOI":"10.1021\/acschemneuro.8b00625"},{"key":"e_1_2_16_323_1","doi-asserted-by":"publisher","DOI":"10.1523\/eneuro.0208-18.2018"},{"key":"e_1_2_16_324_1","doi-asserted-by":"publisher","DOI":"10.1016\/0014-2999(89)90510-4"},{"key":"e_1_2_16_325_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.17458"},{"key":"e_1_2_16_326_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-022-04434-5"},{"key":"e_1_2_16_327_1","doi-asserted-by":"publisher","DOI":"10.3389\/fncir.2021.795325"},{"key":"e_1_2_16_328_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0953-23.2024"},{"key":"e_1_2_16_329_1","doi-asserted-by":"publisher","DOI":"10.1096\/fj.04-1575fje"},{"key":"e_1_2_16_330_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0301-0082(98)00092-6"},{"key":"e_1_2_16_331_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2012.10.018"},{"key":"e_1_2_16_332_1","doi-asserted-by":"publisher","DOI":"10.1016\/0169-328x(94)90375-1"},{"key":"e_1_2_16_333_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0079-6123(03)45003-6"},{"key":"e_1_2_16_334_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41398-021-01613-2"},{"key":"e_1_2_16_335_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2021.07.038"},{"key":"e_1_2_16_336_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702201"},{"key":"e_1_2_16_337_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.186"},{"key":"e_1_2_16_338_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-004-1940-5"},{"key":"e_1_2_16_339_1","doi-asserted-by":"publisher","DOI":"10.1021\/cn400121z"},{"key":"e_1_2_16_340_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0014-2999(00)00935-3"},{"key":"e_1_2_16_341_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.100021"},{"key":"e_1_2_16_342_1","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/dds331"},{"key":"e_1_2_16_343_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1398-x"},{"key":"e_1_2_16_344_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci85033"},{"key":"e_1_2_16_345_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.bjp.0702463"},{"key":"e_1_2_16_346_1","doi-asserted-by":"publisher","DOI":"10.1021\/acsmedchemlett.6b00461"},{"key":"e_1_2_16_347_1","doi-asserted-by":"publisher","DOI":"10.1017\/s146114570500516x"},{"key":"e_1_2_16_348_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2008.12.020"},{"key":"e_1_2_16_349_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.schres.2010.08.027"},{"key":"e_1_2_16_350_1","doi-asserted-by":"publisher","DOI":"10.1042\/bj3380619"},{"key":"e_1_2_16_351_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.00533.2002"},{"key":"e_1_2_16_352_1","doi-asserted-by":"publisher","DOI":"10.3389\/fnins.2022.816331"},{"key":"e_1_2_16_353_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1476-5381.2009.00175.x"},{"key":"e_1_2_16_354_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.5719-09.2010"},{"key":"e_1_2_16_355_1","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.274.4.1957"},{"key":"e_1_2_16_356_1","doi-asserted-by":"publisher","DOI":"10.1002\/syn.20548"},{"key":"e_1_2_16_357_1","doi-asserted-by":"publisher","DOI":"10.1093\/oxfordjournals.schbul.a033333"},{"key":"e_1_2_16_358_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300367"},{"key":"e_1_2_16_359_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2026.1774437"},{"key":"e_1_2_16_360_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.123.001737"},{"key":"e_1_2_16_361_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0014-2999(96)00956-9"},{"key":"e_1_2_16_362_1","doi-asserted-by":"publisher","DOI":"10.1152\/jn.01025.2001"},{"key":"e_1_2_16_363_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.22-05-01709.2002"},{"key":"e_1_2_16_364_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.22-15-06347.2002"},{"key":"e_1_2_16_365_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-005-2258-7"},{"key":"e_1_2_16_366_1","doi-asserted-by":"publisher","DOI":"10.1523\/jneurosci.21-04-01148.2001"},{"key":"e_1_2_16_367_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neulet.2005.06.035"},{"key":"e_1_2_16_368_1","doi-asserted-by":"publisher","DOI":"10.1016\/0922-4106(94)90047-7"},{"key":"e_1_2_16_369_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2017.11.036"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70582","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.70582","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70582","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T08:59:38Z","timestamp":1788339578000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.70582"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,4]]},"references-count":368,"journal-issue":{"issue":"19","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/bph.70582"],"URL":"https:\/\/doi.org\/10.1111\/bph.70582","archive":["Portico"],"relation":{"has-preprint":[{"id-type":"doi","id":"10.22541\/au.175404639.94761734\/v1","asserted-by":"object"}]},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,4]]},"assertion":[{"value":"2025-07-31","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-13","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-04","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}