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I\/R injury initiates complex molecular and cellular cascades that drive cellular dysfunction, structural damage and both acute and chronic organ failure. Despite advances in supportive care, pharmacological intervention remains the primary strategy for protecting organs from I\/R injury. Tanshinones, a group of lipophilic abietane diterpenoids derived from\n                    <jats:styled-content style=\"fixed-case\">\n                      <jats:italic>Salvia miltiorrhiza<\/jats:italic>\n                    <\/jats:styled-content>\n                    , display convergent, multi\u2010target pharmacological activities that closely correspond to the core pathogenic mechanisms of I\/R injury. Over the past two decades, tanshinones, particularly Tan IIA, Tan I and cryptotanshinone, have shown cardioprotective and neuroprotective effects. Increasing evidence further indicates that tanshinones also protect against I\/R injury in other organs. This review synthesizes current findings on bioactive tanshinone analogues, their pharmacodynamic properties and underlying mechanisms of action and discusses biomarker\u2010guided strategies to advance tanshinones as practical, pleiotropic therapeutic candidates for multi\u2010organ I\/R injury.\n                  <\/jats:p>","DOI":"10.1111\/bph.70583","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T06:55:38Z","timestamp":1786604138000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Therapeutic potential of tanshinones in ischaemia\u2013reperfusion injury: Bioactive analogues, pharmacology and mechanisms"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7941-2920","authenticated-orcid":false,"given":"Meijie","family":"Dai","sequence":"first","affiliation":[{"name":"Institute of Pharmacology &amp; Toxicology, Zhejiang Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-3682-1988","authenticated-orcid":false,"given":"Yimu","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology &amp; Toxicology, Zhejiang Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-4985-3539","authenticated-orcid":false,"given":"Chenze","family":"Zhu","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology &amp; Toxicology, Zhejiang Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-4074-8693","authenticated-orcid":false,"given":"Yuyan","family":"Yang","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9407-5190","authenticated-orcid":false,"given":"Sunliang","family":"Cui","sequence":"additional","affiliation":[{"name":"College of Pharmaceutical Sciences, State Key Laboratory of Advanced Drug Delivery and Release Systems Zhejiang University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7603-7403","authenticated-orcid":false,"given":"Xiangnan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Pharmacology &amp; Toxicology, Zhejiang Key Laboratory of Neuropsychopharmacology, State Key Laboratory of Advanced Drug Delivery and Release Systems, College of Pharmaceutical Sciences Zhejiang University  Hangzhou China"},{"name":"Zhejiang Provincial Engineering Research Center for Innovative Small\u2010Molecule Drugs Jinhua Institute of Zhejiang University  Jinhua China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70230"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70234"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70233"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70229"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajt.16164"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S331690"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/bcpt.13275"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/0886022X.2024.2433710"},{"key":"e_1_2_12_10_1","unstructured":"BiY. 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