{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:13:39Z","timestamp":1789172019556,"version":"build-2803163510"},"reference-count":37,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T00:00:00Z","timestamp":1784160000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000289","name":"Cancer Research UK","doi-asserted-by":"publisher","award":["DRCMDP\u2010May23\/100005"],"award-info":[{"award-number":["DRCMDP\u2010May23\/100005"]}],"id":[{"id":"10.13039\/501100000289","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>\n                      Oxidative stress plays a critical role in the pathophysiology of various diseases, yet current methods for its non\u2010invasive detection remain limited. This study aimed to systematically validate a superoxide\u2010selective PET tracer, [\n                      <jats:sup>18<\/jats:sup>\n                      F]FPBT, for the early diagnosis and therapeutic monitoring of oxidative stress\u2010related conditions.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>\n                      [\n                      <jats:sup>18<\/jats:sup>\n                      F]FPBT was synthesised using a GMP\u2010compliant, automated production protocol on the Trasis AllinOne platform. The product underwent comprehensive quality control tests to ensure clinical suitability. Preclinical imaging was conducted using a clinical PET scanner in LPS\u2010 and doxorubicin\u2010treated rabbits, to assess tracer uptake in organs subject to oxidative stress. Radiation dosimetry was measured in healthy rabbits to estimate effective human doses. Acute toxicity was evaluated using nonradioactive FPBT in KM mice (1.875\u2009mg\u00b7kg\n                      <jats:sup>\u22121<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>\n                      [\n                      <jats:sup>18<\/jats:sup>\n                      F]FPBT was successfully produced with batch yields ranging from 2.69 to 4.64\u2009GBq when starting from 19.20\u201368.45\u2009GBq of fluoride\u201018. PET imaging demonstrated clear visualisation of cardiac oxidative stress in LPS\u2010 and doxorubicin\u2010treated rabbits. Estimated human radiation doses were 0.022\u2009\u00b1\u20090.004\u2009mSv\u00b7MBq\n                      <jats:sup>\u22121<\/jats:sup>\n                      for males and 0.028\u2009\u00b1\u20090.005\u2009mSv\u00b7MBq\n                      <jats:sup>\u22121<\/jats:sup>\n                      for females, comparable to [\n                      <jats:sup>18<\/jats:sup>\n                      F]FDG. No treatment\u2010related adverse effects were observed in mice administered FBPT at a dose corresponding to 8896\u2010fold the projected nonradioactive mass dose for a 150\u2010MBq [\n                      <jats:sup>18<\/jats:sup>\n                      F]FBPT PET scan in humans.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications<\/jats:title>\n                    <jats:p>\n                      [\n                      <jats:sup>18<\/jats:sup>\n                      F]FPBT meets the regulatory and biological safety criteria for human use and shows strong potential for first\u2010in\u2010human PET imaging studies. This tracer could enable early diagnosis, monitoring and treatment evaluation in cardiovascular diseases characterised by elevated oxidative stress.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70593","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T02:07:18Z","timestamp":1784254038000},"page":"6028-6045","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["GMP\u2010compliant production, validation and dosimetry of clinical grade [\n                    <sup>18<\/sup>\n                    F]3\u2010(3\u2010fluoropropyl)\u20102\u2010phenyl\u20102,3\u2010dihydrobenzo[d]thiazole ([\n                    <sup>18<\/sup>\n                    F]FPBT) for oxidative stress PET imaging"],"prefix":"10.1111","volume":"183","author":[{"given":"Hua","family":"Zhang","sequence":"first","affiliation":[{"name":"Department of Nuclear Medicine First Affiliated Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangfang","family":"Sun","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine First Affiliated Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine First Affiliated Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine First Affiliated Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuexuan","family":"Song","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine First Affiliated Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lu","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Nuclear Medicine First Affiliated Hospital of Dalian Medical University  Dalian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Gape","sequence":"additional","affiliation":[{"name":"School of Biomedical Engineering and Imaging Sciences, Department of Imaging Chemistry and Biology King's College London  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samantha Y. 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