{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:13:05Z","timestamp":1789171985144,"version":"build-2803163510"},"reference-count":85,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"},{"start":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T00:00:00Z","timestamp":1784592000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["168971"],"award-info":[{"award-number":["168971"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Purpose<\/jats:title>\n                    <jats:p>Cocaine\u2010associated cues trigger relapse to drug use in humans and animal models. In rats, long daily cocaine access (4\u20136 vs. 1\u20132\u2009h) increases drug self\u2010administration and cue\u2010induced cocaine seeking, suggesting that greater intake promotes relapse. However, prior studies used continuous drug access paradigms, whereas human cocaine use is typically intermittent. Prior studies also used conditioned stimuli (CS), whereas discriminative stimuli (DS) are more effective in triggering drug seeking. Here, we used intermittent access (IntA) self\u2010administration to examine how session length influences CS\u2010 and DS\u2010induced cocaine seeking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Experimental Approach<\/jats:title>\n                    <jats:p>Female rats self\u2010administered cocaine intermittently during daily 2\u2010 or 4\u2010h IntA sessions (Short\u2010IntA and Long\u2010IntA), with alternating DS+ (cocaine available; 5\u2009min) and DS\u2212 (no cocaine; 25\u2009min) periods. Lever pressing during DS+ produced cocaine and a CS+; lever pressing during DS\u2212 produced only a CS\u2212. After 4\u2009weeks of abstinence, rats received a test where all cues were presented response\u2010independently, and lever presses\u2014which had no consequence\u2014measured cocaine seeking.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Key Results<\/jats:title>\n                    <jats:p>Long\u2010IntA rats took twice more cocaine than did Short\u2010IntA rats. In both groups, DS+ but not CS+ later triggered significant increases in cocaine seeking, with no group differences. Thus, total intake did not predict cue\u2010induced relapse intensity. However, individual cocaine intake patterns did, including hourly consumption, episodes of burst\u2010like self\u2010administration and latency to self\u2010administer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions and Implications<\/jats:title>\n                    <jats:p>Under intermittent\u2010access conditions, individual cocaine\u2010use patterns, not cumulative intake, predict vulnerability to cue\u2010induced relapse. This highlights the importance of individual drug\u2010taking profiles in relapse risk assessment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70596","type":"journal-article","created":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T06:07:39Z","timestamp":1784700459000},"page":"6094-6112","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Intermittent cocaine use patterns, not total intake, predict cue\u2010induced drug seeking in rats"],"prefix":"10.1111","volume":"183","author":[{"given":"Am\u00e9lie","family":"Mainville\u2010Berthiaume","sequence":"first","affiliation":[{"name":"Department of Pharmacology and Physiology, Faculty of Medicine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"},{"name":"Neural Signaling and Circuitry Research Group (SNC), Faculty of Medicine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"},{"name":"Center for Biomedical Innovation (CIB) Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"},{"name":"Center for Interdisciplinary Research on the Brain and Learning (CIRCA) Universit\u00e9 de Montr\u00e9al  Montreal Quebecs Canada"},{"name":"Center for Studies in Behavioural Neurobiology Concordia University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hajer","family":"Algallal","sequence":"additional","affiliation":[{"name":"Neural Signaling and Circuitry Research Group (SNC), Faculty of Medicine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"},{"name":"Center for Biomedical Innovation (CIB) Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"},{"name":"Center for Interdisciplinary Research on the Brain and Learning (CIRCA) Universit\u00e9 de Montr\u00e9al  Montreal Quebecs Canada"},{"name":"Center for Studies in Behavioural Neurobiology Concordia University  Montreal Quebec Canada"},{"name":"Department of Biomedical Sciences, Faculty of Medicine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salom\u00e9","family":"Dupuis","sequence":"additional","affiliation":[{"name":"Department of Biomedical Sciences, Faculty of Medicine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sema Abu","family":"Shamleh","sequence":"additional","affiliation":[{"name":"Center for Studies in Behavioural Neurobiology Concordia University  Montreal Quebec Canada"},{"name":"Department of Psychology, Faculty of Arts and Science Concordia University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Coralie","family":"Godbout","sequence":"additional","affiliation":[{"name":"Department of Psychology, Faculty of Arts and Science Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Jacquemet","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology, Faculty of Medicine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"},{"name":"Center for Biomedical Innovation (CIB) Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne\u2010No\u00ebl","family":"Samaha","sequence":"additional","affiliation":[{"name":"Department of Pharmacology and Physiology, Faculty of Medicine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"},{"name":"Neural Signaling and Circuitry Research Group (SNC), Faculty of Medicine Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"},{"name":"Center for Biomedical Innovation (CIB) Universit\u00e9 de Montr\u00e9al  Montreal Quebec Canada"},{"name":"Center for Interdisciplinary Research on the Brain and Learning (CIRCA) Universit\u00e9 de Montr\u00e9al  Montreal Quebecs Canada"},{"name":"Center for Studies in Behavioural Neurobiology Concordia University  Montreal Quebec Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,21]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0893-133X(99)00133-5"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.08.014"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.282.5387.298"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16177"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.16178"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12809"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-024-06546-4"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1101\/2025.06.23.661090"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-017-4773-8"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41386-020-0773-1"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2015.06.012"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12629"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0091-3057(01)00573-1"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/adb.12544"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2008.05.031"},{"key":"e_1_2_12_17_1","unstructured":"Beveridge T. Wray P. &Brewer A.(2012).Analyzing human cocaine use patterns to inform animal addiction model development [Conference presentation]. College on Problems of Drug Dependence Annual Meeting Palm Springs CA United States."},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1001\/archpsyc.63.12.1386"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.4370-06.2007"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1124\/jpet.114.212993"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.136"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-021-06023-2"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.98.4.1976"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.3109\/16066359409005547"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-022-06218-1"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep46665"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1037\/a0017778"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.90422.3"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.2024121118"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1099020"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1037\/0735-7044.117.5.952"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15791"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/0091-3057(94)00256-I"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2005.04.046"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.3278-12.2013"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuroscience.2011.09.004"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2013.77"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.drugalcdep.2007.10.005"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2018.07.022"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2010.82"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-003-1393-2"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-019-5164-0"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-016-4393-8"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-018-5091-5"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejn.14418"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-006-0386-3"},{"key":"e_1_2_12_47_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.npp.1300779"},{"key":"e_1_2_12_48_1","doi-asserted-by":"crossref","unstructured":"LeCocq M. R. Mainville\u2010Berthiaume A. Laplante I. &Samaha A.\u2010N.(2024).Activation of group II metabotropic glutamate receptors in the basolateral amygdala inhibits reward seeking triggered by discriminative stimuli [Preprint]. bioRxiv.https:\/\/doi.org\/10.1101\/2024.10.11.617854","DOI":"10.1101\/2024.10.11.617854"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-025-06764-4"},{"key":"e_1_2_12_50_1","doi-asserted-by":"publisher","DOI":"10.1139\/jpn.0405"},{"key":"e_1_2_12_51_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pnpbp.2007.08.027"},{"key":"e_1_2_12_52_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neubiorev.2013.01.018"},{"key":"e_1_2_12_53_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2014.04.002"},{"key":"e_1_2_12_54_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.15178"},{"key":"e_1_2_12_55_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.44427"},{"key":"e_1_2_12_56_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0912955107"},{"key":"e_1_2_12_57_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-022-06204-7"},{"key":"e_1_2_12_58_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2014.66"},{"key":"e_1_2_12_59_1","doi-asserted-by":"publisher","DOI":"10.1007\/s002130050269"},{"key":"e_1_2_12_60_1","doi-asserted-by":"publisher","DOI":"10.1503\/jpn.150207"},{"key":"e_1_2_12_61_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-024-06614-9"},{"key":"e_1_2_12_62_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopsych.2019.01.015"},{"key":"e_1_2_12_63_1","doi-asserted-by":"publisher","DOI":"10.1124\/pharmrev.121.000367"},{"key":"e_1_2_12_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749-6632.1992.tb25984.x"},{"key":"e_1_2_12_65_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2005.06.018"},{"key":"e_1_2_12_66_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.neuropharm.2021.108566"},{"key":"e_1_2_12_67_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pbio.3000410"},{"key":"e_1_2_12_68_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.20-11-04226.2000"},{"key":"e_1_2_12_69_1","doi-asserted-by":"publisher","DOI":"10.1523\/JNEUROSCI.0990-17.2017"},{"key":"e_1_2_12_70_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-025-06762-6"},{"key":"e_1_2_12_71_1","doi-asserted-by":"publisher","DOI":"10.1016\/0165-0173(93)90013-P"},{"issue":"2","key":"e_1_2_12_72_1","first-page":"149","article-title":"Food or fluid restriction in common laboratory animals: Balancing welfare considerations with scientific inquiry","volume":"57","author":"Rowland N. E.","year":"2007","journal-title":"Comparative Medicine"},{"key":"e_1_2_12_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2021.03.003"},{"key":"e_1_2_12_74_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0026481"},{"key":"e_1_2_12_75_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0376-8716(99)00043-5"},{"key":"e_1_2_12_76_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00213-002-1224-x"},{"key":"e_1_2_12_77_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tins.2024.06.007"},{"key":"e_1_2_12_78_1","doi-asserted-by":"publisher","DOI":"10.1037\/0033-295X.91.2.251"},{"key":"e_1_2_12_79_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamapsychiatry.2022.1240"},{"key":"e_1_2_12_80_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.138.3537.143"},{"key":"e_1_2_12_81_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.97.8.4321"},{"key":"e_1_2_12_82_1","doi-asserted-by":"publisher","DOI":"10.46867\/IJCP.2005.18.02.05"},{"key":"e_1_2_12_83_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF00401789"},{"key":"e_1_2_12_84_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0306-4522(03)00531-1"},{"key":"e_1_2_12_85_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2011.165"},{"key":"e_1_2_12_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/npp.2012.37"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70596","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.70596","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70596","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T23:37:02Z","timestamp":1789169822000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.70596"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,21]]},"references-count":85,"journal-issue":{"issue":"20","published-print":{"date-parts":[[2026,10]]}},"alternative-id":["10.1111\/bph.70596"],"URL":"https:\/\/doi.org\/10.1111\/bph.70596","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,21]]},"assertion":[{"value":"2025-10-23","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-06-18","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-21","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}