{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T00:13:03Z","timestamp":1789171983849,"version":"build-2803163510"},"reference-count":41,"publisher":"Wiley","issue":"20","license":[{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"},{"start":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T00:00:00Z","timestamp":1784246400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82000206"],"award-info":[{"award-number":["82000206"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"published-print":{"date-parts":[[2026,10]]},"abstract":"<jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Kinase inhibitors (KIs) are essential in targeted cancer therapy but frequently cause cardiotoxicity, limiting their clinical utility. A systematic resource to explore the underlying causal mechanisms is urgently needed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We developed the Kinase Inhibitor Cardiotoxicity Database (KICDB ), an interactive web platform integrating large\u2010scale transcriptomic meta\u2010analysis with causal inference to identify molecular determinants of KI\u2010induced cardiotoxicity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Meta\u2010analysis of 5291 samples revealed a convergent disruption of the cellular mitotic machinery, specifically chromosome segregation and nuclear division, as a shared mechanism of toxicity across multiple KI classes. Furthermore, Mendelian randomization (MR) analysis identified 26 robust causal associations, linking specific kinase targets (e.g. RING finger protein 13 [RNF13] and tyrosine kinase with immunoglobulin like and EGF like domains 1 [TIE1]) to increased risks of cardiomyopathy and myocardial infarction, while identifying TYRO3 protein tyrosine kinase [Tyro3] and Janus kinase 2 (JAK2) as potential cardioprotective factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>KICDB provides a mechanistic framework linking transcriptomic perturbations with genetically validated causal drivers. By linking transcriptomic perturbations with causal validation, it serves as a resource to advance biomarker discovery, mechanistic exploration and the design of cardioprotective strategies.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/bph.70599","type":"journal-article","created":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T07:47:57Z","timestamp":1784274477000},"page":"6046-6058","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Kinase Inhibitor Cardiotoxicity Database (KICDB): a causality\u2010oriented multi\u2010omics database for kinase inhibitor\u2010induced cardiotoxicity"],"prefix":"10.1111","volume":"183","author":[{"given":"Jiamin","family":"Wei","sequence":"first","affiliation":[{"name":"Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences) Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Environment, Hangzhou Institute for Advanced Study University of Chinese Academy of Sciences  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miaoqing","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Digestive Diseases Center The Seventh Affiliated Hospital, Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoyuan","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Pediatric Surgery, Guangzhou Women and Children's Medical Center Guangzhou Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinyao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Jieyang People's Hospital  Jieyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huafeng","family":"Fu","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Digestive Medicine Center The Seventh Affiliated Hospital, Sun Yat\u2010sen University  Shenzhen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Gastrointestinal Surgery, Digestive Medicine Center The Seventh Affiliated Hospital, Sun Yat\u2010sen University  Shenzhen China"},{"name":"Department of General Surgery Linzhi People's Hospital  Linzhi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jijin","family":"Lin","sequence":"additional","affiliation":[{"name":"Guangdong Cardiovascular Institute Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University  Guangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,7,17]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70233"},{"key":"e_1_2_12_3_1","volume-title":"visNetwork: Network visualization using \u2018vis.js\u2019 library","author":"Almende B. 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