{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T07:28:37Z","timestamp":1786606117122,"version":"build-2736575974"},"reference-count":211,"publisher":"Wiley","license":[{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T00:00:00Z","timestamp":1786492800000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["bpspubs.onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["British J Pharmacology"],"abstract":"<jats:p>Long non\u2010coding RNAs (lncRNAs), a broad class of non\u2010protein\u2010coding RNAs, are characterized as new regulators of gene expression at the epigenetic, transcriptional, and post\u2010transcriptional level. Thus, lncRNAs are involved in the regulation of physiological processes and the development of human diseases and cancer by modulating proinflammatory, oncogenic and proangiogenic pathways. Inflammation, cancer and angiogenesis are interlinked through a network of signals and pathways that reinforces itself through feedback loops. Inflammation triggers vessel formation to transfer immune cells and nutrients, and consequently the new vessels enhance the supply of inflammatory cells and factors. Chronic inflammation induces oncogenic transformation and angiogenesis, induced by tumour\u2010derived signals, support tumour growth and provide the route for distal metastasis. Here we review the implication of lncRNAs in these processes and interactions in the gastrointestinal tract, with a special focus on inflammation and cancer angiogenesis. LncRNAs, due to their highly cell\u2010, tissue\u2010 and disease\u2010specific expression, are attractive targets for the development of novel therapeutics with limited off\u2010target effects and toxicity. We discuss new discoveries which highlight the value of lncRNA targeting as therapeutic applications, in gastrointestinal inflammation and cancer angiogenesis, and identify gaps in our current knowledge and understanding. We illustrate advancing approaches, their advantages and challenges for the pharmacological targeting of lncRNAs.<\/jats:p>","DOI":"10.1111\/bph.70634","type":"journal-article","created":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T06:45:41Z","timestamp":1786603541000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Long non\u2010coding RNAs at the crossroads of inflammation, cancer and angiogenesis: Molecular mechanisms and their potential as therapeutic targets"],"prefix":"10.1111","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-4699-4243","authenticated-orcid":false,"given":"Charlie","family":"Leboff","sequence":"first","affiliation":[{"name":"Department of Biosciences, Centre for Systems Health and Integrated Metabolic Research, John van Geest Cancer Research Centre, School of Science and Technology Nottingham Trent University  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-5093-8929","authenticated-orcid":false,"given":"Pamela","family":"Calle\u2010Mendoza","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Centre for Systems Health and Integrated Metabolic Research, John van Geest Cancer Research Centre, School of Science and Technology Nottingham Trent University  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2493-7028","authenticated-orcid":false,"given":"Maria","family":"Hatziapostolou","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Centre for Systems Health and Integrated Metabolic Research, John van Geest Cancer Research Centre, School of Science and Technology Nottingham Trent University  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1948-7934","authenticated-orcid":false,"given":"Christos","family":"Polytarchou","sequence":"additional","affiliation":[{"name":"Department of Biosciences, Centre for Systems Health and Integrated Metabolic Research, John van Geest Cancer Research Centre, School of Science and Technology Nottingham Trent University  Nottingham UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2026,8,12]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.5114\/ceh.2023.127569"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkag392"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70232"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70234"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70233"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/bph.70229"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1002\/chem.201802691"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells10081883"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-2245-2"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002722"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1146\/annurev-pharmtox-010716-104846"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2018.03.052"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0006-2952(00)00427-5"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkad257"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90519-I"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/0092-8674(92)90520-M"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/nsmb.2844"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2012.802"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12272-021-01317-7"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers16172940"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature10144"},{"issue":"1","key":"e_1_2_10_23_1","doi-asserted-by":"crossref","DOI":"10.1186\/s13046-024-03095-8","article-title":"A novel lncRNA LOC101928222 promotes colorectal cancer angiogenesis by stabilizing HMGCS2 mRNA and increasing cholesterol synthesis","volume":"43","author":"Chang L.","year":"2024","journal-title":"Journal of Experimental & Clinical Cancer Research"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.12.023"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-021-04093-w"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-018-0962-6"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2020.10.001"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.2147\/JHC.S404008"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2009.01.026"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-015-0426-x"},{"key":"e_1_2_10_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/wrna.1796"},{"key":"e_1_2_10_32_1","doi-asserted-by":"publisher","DOI":"10.1080\/15476286.2016.1197482"},{"key":"e_1_2_10_33_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-007-9074-0"},{"key":"e_1_2_10_34_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S281578"},{"key":"e_1_2_10_35_1","doi-asserted-by":"publisher","DOI":"10.1101\/gr.132159.111"},{"key":"e_1_2_10_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s11658-020-00204-1"},{"key":"e_1_2_10_37_1","doi-asserted-by":"publisher","DOI":"10.1177\/15330338231184327"},{"key":"e_1_2_10_38_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcp.29503"},{"key":"e_1_2_10_39_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1432"},{"key":"e_1_2_10_40_1","doi-asserted-by":"publisher","DOI":"10.1530\/REP-18-0530"},{"key":"e_1_2_10_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0195-668x(02)00635-8"},{"key":"e_1_2_10_42_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJM197111182852108"},{"key":"e_1_2_10_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2020.107933"},{"key":"e_1_2_10_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432-025-06420-6"},{"key":"e_1_2_10_45_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13578-017-0192-0"},{"key":"e_1_2_10_46_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2019.00720"},{"key":"e_1_2_10_47_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11010-025-05453-2"},{"key":"e_1_2_10_48_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.09.029"},{"key":"e_1_2_10_49_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-019-0328-x"},{"key":"e_1_2_10_50_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.08.021"},{"key":"e_1_2_10_51_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcla.22986"},{"key":"e_1_2_10_52_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2016.00338"},{"key":"e_1_2_10_53_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16477"},{"key":"e_1_2_10_54_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI125581"},{"key":"e_1_2_10_55_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2025.12.049"},{"key":"e_1_2_10_56_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastha.2024.04.005"},{"key":"e_1_2_10_57_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2019.11.021"},{"key":"e_1_2_10_58_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers14112713"},{"key":"e_1_2_10_59_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.11.008"},{"key":"e_1_2_10_60_1","doi-asserted-by":"publisher","DOI":"10.1126\/scitranslmed.aac5272"},{"key":"e_1_2_10_61_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2020-322780"},{"key":"e_1_2_10_62_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.58422"},{"key":"e_1_2_10_63_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00510.2018"},{"key":"e_1_2_10_64_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgh.15362"},{"key":"e_1_2_10_65_1","doi-asserted-by":"publisher","DOI":"10.3892\/mmr.2016.5580"},{"key":"e_1_2_10_66_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCRESAHA.119.315856"},{"key":"e_1_2_10_67_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-02140-0"},{"issue":"6","key":"e_1_2_10_68_1","doi-asserted-by":"crossref","DOI":"10.3892\/or.2021.8207","article-title":"Interactions between long non\u2010coding RNAs and RNA\u2010binding proteins in cancer","volume":"46","author":"Huang H.","year":"2021","journal-title":"Oncology Reports"},{"key":"e_1_2_10_69_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13045-015-0146-0"},{"key":"e_1_2_10_70_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1518628"},{"key":"e_1_2_10_71_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40824-022-00292-4"},{"key":"e_1_2_10_72_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-023-06274-1"},{"key":"e_1_2_10_73_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2018.08.024"},{"key":"e_1_2_10_74_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-2164-8-39"},{"key":"e_1_2_10_75_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng.3192"},{"key":"e_1_2_10_76_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2022.113237"},{"key":"e_1_2_10_77_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-020-01217-8"},{"issue":"7","key":"e_1_2_10_78_1","first-page":"1354","article-title":"Emerging roles of lncRNA in cancer and therapeutic opportunities","volume":"9","author":"Jiang M.\u2010C.","year":"2019","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_10_79_1","doi-asserted-by":"publisher","DOI":"10.1155\/2018\/5340894"},{"key":"e_1_2_10_80_1","doi-asserted-by":"publisher","DOI":"10.1021\/jacs.6b04506"},{"key":"e_1_2_10_81_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a041172"},{"key":"e_1_2_10_82_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.0904715106"},{"key":"e_1_2_10_83_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.12.033"},{"key":"e_1_2_10_84_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature09033"},{"issue":"2","key":"e_1_2_10_85_1","doi-asserted-by":"crossref","DOI":"10.1038\/nrg.2016.168","article-title":"Screening for lncRNA function","volume":"18","author":"Koch L.","year":"2017","journal-title":"Nature Reviews Genetics"},{"key":"e_1_2_10_86_1","doi-asserted-by":"publisher","DOI":"10.1038\/nmeth.3965"},{"key":"e_1_2_10_87_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1388-4"},{"key":"e_1_2_10_88_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.113325"},{"issue":"3","key":"e_1_2_10_89_1","doi-asserted-by":"crossref","first-page":"66","DOI":"10.29245\/2572-9411\/2016\/3.1066","article-title":"Mini\u2010review on current strategies to knockdown long non\u2010coding RNAs","volume":"1","author":"Lennox K. A.","year":"2016","journal-title":"Journal of Rare Diseases Research & Treatment"},{"key":"e_1_2_10_90_1","doi-asserted-by":"publisher","DOI":"10.1111\/cpr.12632"},{"key":"e_1_2_10_91_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1097-2765(04)00157-1"},{"key":"e_1_2_10_92_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-021-02143-x"},{"key":"e_1_2_10_93_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejphar.2019.01.049"},{"key":"e_1_2_10_94_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.celrep.2023.112542"},{"key":"e_1_2_10_95_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers12102995"},{"key":"e_1_2_10_96_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2017.02.035"},{"key":"e_1_2_10_97_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202403077"},{"key":"e_1_2_10_98_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-019-1473-8"},{"key":"e_1_2_10_99_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0727-1"},{"key":"e_1_2_10_100_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gky046"},{"key":"e_1_2_10_101_1","doi-asserted-by":"publisher","DOI":"10.1002\/cac2.12507"},{"key":"e_1_2_10_102_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izae212"},{"key":"e_1_2_10_103_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-020-0836-4"},{"key":"e_1_2_10_104_1","doi-asserted-by":"publisher","DOI":"10.1002\/ctm2.1410"},{"key":"e_1_2_10_105_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10565-020-09524-6"},{"key":"e_1_2_10_106_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-12893-4"},{"key":"e_1_2_10_107_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.lfs.2021.119569"},{"key":"e_1_2_10_108_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2020.618930"},{"key":"e_1_2_10_109_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217085"},{"key":"e_1_2_10_110_1","doi-asserted-by":"publisher","DOI":"10.1093\/ibd\/izy381"},{"key":"e_1_2_10_111_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9440(10)65173-5"},{"key":"e_1_2_10_112_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature25501"},{"key":"e_1_2_10_113_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature05519"},{"key":"e_1_2_10_114_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41580-022-00566-8"},{"key":"e_1_2_10_115_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2020.10.018"},{"key":"e_1_2_10_116_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tips.2022.01.008"},{"key":"e_1_2_10_117_1","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms8743"},{"key":"e_1_2_10_118_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkab1208"},{"key":"e_1_2_10_119_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep28532"},{"key":"e_1_2_10_120_1","doi-asserted-by":"publisher","DOI":"10.1101\/cshperspect.a026336"},{"key":"e_1_2_10_121_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpgi.00212.2016"},{"key":"e_1_2_10_122_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-016-0281-9"},{"key":"e_1_2_10_123_1","doi-asserted-by":"publisher","DOI":"10.21037\/atm-21-34"},{"key":"e_1_2_10_124_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2008.08.022"},{"key":"e_1_2_10_125_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pharmthera.2016.03.004"},{"key":"e_1_2_10_126_1","doi-asserted-by":"publisher","DOI":"10.1136\/gutjnl-2019-318903"},{"key":"e_1_2_10_127_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1084274"},{"key":"e_1_2_10_128_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.08.039"},{"key":"e_1_2_10_129_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.omtn.2019.08.020"},{"key":"e_1_2_10_130_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2021.04.042"},{"key":"e_1_2_10_131_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2007.05.022"},{"key":"e_1_2_10_132_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.chembiol.2023.08.010"},{"key":"e_1_2_10_133_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.07.014"},{"key":"e_1_2_10_134_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature11247"},{"key":"e_1_2_10_135_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccell.2016.03.010"},{"key":"e_1_2_10_136_1","doi-asserted-by":"publisher","DOI":"10.1101\/gad.590910"},{"key":"e_1_2_10_137_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrc1187"},{"key":"e_1_2_10_138_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.1019711108"},{"key":"e_1_2_10_139_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12915-025-02322-8"},{"key":"e_1_2_10_140_1","doi-asserted-by":"publisher","DOI":"10.1080\/15384047.2020.1738908"},{"key":"e_1_2_10_141_1","doi-asserted-by":"publisher","DOI":"10.1093\/nar\/gkaa475"},{"key":"e_1_2_10_142_1","doi-asserted-by":"publisher","DOI":"10.1038\/nri2779"},{"key":"e_1_2_10_143_1","doi-asserted-by":"publisher","DOI":"10.1002\/jcb.27743"},{"key":"e_1_2_10_144_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0092-8674(00)81780-8"},{"key":"e_1_2_10_145_1","doi-asserted-by":"publisher","DOI":"10.1038\/nrm2728"},{"key":"e_1_2_10_146_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2020.104120"},{"key":"e_1_2_10_147_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.47548"},{"key":"e_1_2_10_148_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12935-019-0799-9"},{"issue":"10","key":"e_1_2_10_149_1","doi-asserted-by":"crossref","DOI":"10.3724\/abbs.2025141","article-title":"LINC00114 promotes colorectal cancer metastasis by targeting HNRNPA1 to regulate glutamine metabolism reprogramming and angiogenesis: LINC00114 promotes CRC metastasis by targeting HNRNPA1","volume":"57","author":"Tang S.","year":"2025","journal-title":"Acta Biochimica et Biophysica Sinica"},{"key":"e_1_2_10_150_1","doi-asserted-by":"publisher","DOI":"10.1002\/1878-0261.12911"},{"key":"e_1_2_10_151_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2010.09.049"},{"key":"e_1_2_10_152_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.molcel.2010.08.011"},{"key":"e_1_2_10_153_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1192002"},{"key":"e_1_2_10_154_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.biopha.2020.110642"},{"key":"e_1_2_10_155_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2023.101730"},{"key":"e_1_2_10_156_1","doi-asserted-by":"publisher","DOI":"10.1172\/jci122478"},{"key":"e_1_2_10_157_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gde.2024.102158"},{"key":"e_1_2_10_158_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2025.2564284"},{"key":"e_1_2_10_159_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcimb.2022.913815"},{"key":"e_1_2_10_160_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.devcel.2024.12.013"},{"key":"e_1_2_10_161_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10753-024-02170-8"},{"key":"e_1_2_10_162_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2018.1503913"},{"key":"e_1_2_10_163_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12967-019-02145-6"},{"key":"e_1_2_10_164_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41418-019-0449-8"},{"key":"e_1_2_10_165_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-019-1123-9"},{"key":"e_1_2_10_166_1","doi-asserted-by":"publisher","DOI":"10.1155\/2021\/5547345"},{"key":"e_1_2_10_167_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41573-021-00219-z"},{"key":"e_1_2_10_168_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yexcr.2020.112025"},{"key":"e_1_2_10_169_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ymthe.2020.10.011"},{"key":"e_1_2_10_170_1","doi-asserted-by":"publisher","DOI":"10.1158\/0008-5472.CAN-20-3747"},{"key":"e_1_2_10_171_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2013.08.014"},{"key":"e_1_2_10_172_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2024.217088"},{"key":"e_1_2_10_173_1","doi-asserted-by":"publisher","DOI":"10.1002\/advs.202400695"},{"key":"e_1_2_10_174_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2014.10.013"},{"key":"e_1_2_10_175_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-020-01512-8"},{"key":"e_1_2_10_176_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13402-019-00490-8"},{"key":"e_1_2_10_177_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41417-020-00277-2"},{"key":"e_1_2_10_178_1","doi-asserted-by":"publisher","DOI":"10.3389\/fcell.2021.705697"},{"key":"e_1_2_10_179_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00018-024-05172-9"},{"key":"e_1_2_10_180_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.phrs.2022.106549"},{"key":"e_1_2_10_181_1","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.79811"},{"key":"e_1_2_10_182_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-018-07224-8"},{"key":"e_1_2_10_183_1","doi-asserted-by":"publisher","DOI":"10.1038\/s12276-018-0188-9"},{"key":"e_1_2_10_184_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-019-13313-z"},{"issue":"1","key":"e_1_2_10_185_1","doi-asserted-by":"crossref","DOI":"10.1186\/s12967-021-02769-7","article-title":"LncRNA\u2010Gm9795 promotes inflammation in non\u2010alcoholic steatohepatitis via NF\u2010\u03baB\/JNK pathway by endoplasmic reticulum stress","volume":"19","author":"Ye L.","year":"2021","journal-title":"Journal of Translational Medicine"},{"key":"e_1_2_10_186_1","doi-asserted-by":"publisher","DOI":"10.1042\/BSR20194062"},{"issue":"3","key":"e_1_2_10_187_1","first-page":"462","article-title":"UXT\u2010AS1\u2010induced alternative splicing of UXT is associated with tumor progression in colorectal cancer","volume":"7","author":"Yin J.","year":"2017","journal-title":"American Journal of Cancer Research"},{"key":"e_1_2_10_188_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.semcdb.2014.05.015"},{"key":"e_1_2_10_189_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-0896-y"},{"key":"e_1_2_10_190_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-018-1014-x"},{"key":"e_1_2_10_191_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.202905"},{"key":"e_1_2_10_192_1","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.93.21.11493"},{"key":"e_1_2_10_193_1","doi-asserted-by":"publisher","DOI":"10.7150\/ijbs.43557"},{"key":"e_1_2_10_194_1","doi-asserted-by":"publisher","DOI":"10.7150\/thno.34559"},{"key":"e_1_2_10_195_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3463"},{"key":"e_1_2_10_196_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41419-020-02808-z"},{"key":"e_1_2_10_197_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-020-01687-8"},{"key":"e_1_2_10_198_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.204078"},{"key":"e_1_2_10_199_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.heliyon.2023.e14655"},{"key":"e_1_2_10_200_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.gastre.2021.09.004"},{"key":"e_1_2_10_201_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-020-01619-6"},{"key":"e_1_2_10_202_1","doi-asserted-by":"publisher","DOI":"10.18632\/aging.103016"},{"key":"e_1_2_10_203_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12950-019-0226-y"},{"key":"e_1_2_10_204_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41388-018-0250-z"},{"key":"e_1_2_10_205_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.1163045"},{"key":"e_1_2_10_206_1","doi-asserted-by":"publisher","DOI":"10.7555\/JBR.38.20240190"},{"issue":"9","key":"e_1_2_10_207_1","first-page":"6117","article-title":"Long non\u2010coding RNA AK001058 regulates tumor growth and angiogenesis in colorectal cancer via methylation of ADAMTS12","volume":"11","author":"Zheng S.","year":"2019","journal-title":"American Journal of Translational Research"},{"key":"e_1_2_10_208_1","doi-asserted-by":"publisher","DOI":"10.1615\/critreveukaryotgeneexpr.2026061564"},{"key":"e_1_2_10_209_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13046-015-0250-6"},{"key":"e_1_2_10_210_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01638-1"},{"key":"e_1_2_10_211_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.tranon.2021.101088"},{"key":"e_1_2_10_212_1","doi-asserted-by":"publisher","DOI":"10.1111\/jcmm.16930"}],"container-title":["British Journal of Pharmacology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70634","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/bph.70634","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/bph.70634","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,8,13]],"date-time":"2026-08-13T06:45:45Z","timestamp":1786603545000},"score":1,"resource":{"primary":{"URL":"https:\/\/bpspubs.onlinelibrary.wiley.com\/doi\/10.1111\/bph.70634"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8,12]]},"references-count":211,"alternative-id":["10.1111\/bph.70634"],"URL":"https:\/\/doi.org\/10.1111\/bph.70634","archive":["Portico"],"relation":{},"ISSN":["0007-1188","1476-5381"],"issn-type":[{"value":"0007-1188","type":"print"},{"value":"1476-5381","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,8,12]]},"assertion":[{"value":"2026-02-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-07-11","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2026-08-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"bph.70634"}}